The Chelsea Critical Care Physical Assessment Tool (CPAx): validation of an innovative new tool to measure physical morbidity in the general adult critical care population; an observational proof-of-concept pilot study.

Objective To develop a scoring system to measure physical morbidity in critical care – the Chelsea Critical Care Physical Assessment Tool (CPAx). Method The development process was iterative involving content validity indices (CVI), a focus group and an observational study of 33 patients to test construct validity against the Medical Research Council score for muscle strength, peak cough flow, Australian Therapy Outcome Measures score, Glasgow Coma Scale score, Bloomsbury sedation score, Sequential Organ Failure Assessment score, Short Form 36 (SF-36) score, days of mechanical ventilation and inter-rater reliability. Participants Trauma and general critical care patients from two London teaching hospitals. Results Users of the CPAx felt that it possessed content validity, giving a final CVI of 1.00 (P < 0.05). Construct validation data showed moderate to strong significant correlations between the CPAx score and all secondary measures, apart from the mental component of the SF-36 which demonstrated weak correlation with the CPAx score (r = 0.024, P = 0.720). Reliability testing showed internal consistency of α = 0.798 and inter-rater reliability of κ = 0.988 (95% confidence interval 0.791 to 1.000) between five raters. Conclusion This pilot work supports proof of concept of the CPAx as a measure of physical morbidity in the critical care population, and is a cogent argument for further investigation of the scoring system

Time dependent diffusion in a disordered medium with partially absorbing walls: A perturbative approach

We present an analytical study of the time dependent diffusion coefficient in a dilute suspension of spheres with partially absorbing boundary condition. Following Kirkpatrick (J. Chem. Phys. 76, 4255) we obtain a perturbative expansion for the time dependent particle density using volume fraction $f$ of spheres as an expansion parameter. The exact single particle $t$-operator for partially absorbing boundary condition is used to obtain a closed form time-dependent diffusion coefficient $D(t)$ accurate to first order in the volume fraction $f$. Short and long time limits of $D(t)$ are checked against the known short-time results for partially or fully absorbing boundary conditions and long-time results for reflecting boundary conditions. For fully absorbing boundary condition the long time diffusion coefficient is found to be $D(t)=5 a^2/(12 f D_{0} t) +O((D_0t/a^2)^{-2})$, to the first order of perturbation theory. Here $f$ is small but non-zero, $D_0$ the diffusion coefficient in the absence of spheres, and $a$ the radius of the spheres. The validity of this perturbative result is discussed

Distances to the high galactic latitude molecular clouds G192-67 and MBM 23-24

We report on distance determinations for two high Galactic latitude cloud complexes, G192-67 and MBM 23-24. No distance determination exists in the literature for either cloud. Thirty-four early type stars were observed towards the two clouds, more than half of which have parallaxes measured by the Hipparcos satellite. For the remaining stars we have made spectroscopic distance estimates. The data consist of high resolution echelle spectra centered on the Na I D lines, and were obtained over six nights at the Coude Feed telescope at Kitt Peak National Observatory. Interstellar absorption lines were detected towards some of the stars, enabling estimates of the distances to the clouds of 109 +/- 14 pc for G192-67, and of 139 +/- 33 pc for MBM 23-24. We discuss the relationship of these clouds to other ISM features such as the Local Hot Bubble and the local cavity in neutral hydrogen.Comment: 15 pages, 6 embedded figures, to be published in the ApJ Vol. 516, No.

Taxonomy, location of origin, and health status of proboscideans from Western Canada investigated using stable isotope analysis

We investigated the application of stable isotope analysis of proboscidean remains (collagen in bone/dentin/cementum and structural carbonate in enamel bioapatite) for genus-level identification of isolated specimens, assessment of geographic origins, and testing for nutritional stress. Mammoths (Mammuthus sp.) tended to have higher δ15Ncol and lower δ13Ccol than mastodons (Mammut americanum), but differences were not significant in every location. Determining the genus of isolated specimens may be possible for locations and time periods with good isotopic baselines, but environmental changes can confound interpretations. For example, an Alberta proboscidean with a δ15Ncol of +1.4‰ (characteristic of mastodons) ultimately proved to be a mammoth. Its surprisingly low nitrogen isotope composition is attributable to the recently deglaciated environment it inhabited. We provided a baseline for isotopic assessment of geographic origins of isolated proboscideans in Western Canada. Bioapatite δ13Csc and δ18Osc can be used to distinguish specimens from Alberta, Klondike, Old Crow, Herschel Island, and further south (e.g., Arizona, Great Lakes). Finally, we found that an Alberta mammoth with morphological evidence of nutritional stress experienced a change in diet, environment, or physiology prior to death, but its isotopic compositions did not suggest a link to hypothesized starvation (catabolism of proteins or reliance on lipids)

Research on mechanisms of alloy strengthening. Part 1 - Strengthening through fine particle dispersion. Part 2 - Control of structure and properties by means of rapid quenching of liquid metals /splat cooling/ Semiannual report

Alloy strengthening mechanisms - strengthening by fine particle dispersion, and structure and properties control by rapid quenching or splat cooling of liquid metal

Functional analysis of a putative membrane-bound endo-β-1,4-glucanase from Panicum virgatum

Cellulose is the most abundant carbohydrate in the world and is degraded by the synergistic action of multiple enzymes. One large family of enzymes capable of hydrolyzing cellulose is glycoside hydrolase family 9 (GH9), which includes several endoglucanases. Recent research into the molecular biology of plants has revealed certain genes coding for endo-β-1,4-glucanases (EGases). The EGases in plants are primarily functional during cell elongation through wall stress relaxation. GH9 enzymes have been found in insects, bacteria, oomycetes, and fungi. In insects, EGases enable the organism to digest cellulose; in fungi, EGases are suspected to play an important role in obtaining nutrition for the fungi and may be associated with defense mechanisms. In these systems, EGases play an important role in breaking the internal bonds of cellulose resulting in a disruption of the crystalline structure. EGases are able to cleave cellulose at the β-1,4 linkages in the cellulose chain with a net inversion of anomeric configuration. A putative EGase from switchgrass (Panicum virgatum) was isolated from leaf cDNA. This gene of interest was cloned into Escherichia coli via the pET160 expression system. Selection by antibiotic resistance confirmed transformation of E. coli. Protein expression was detected via SDS-PAGE and tested to confirm cellulose lysing. The optimal pH and temperature were determined using 3,5-Dinitrosalycilic acid (DNSA) assay at different pH and temperature settings measuring reduced sugars released. Functionality in plants was determined through a gene rescue experiment using Arabidopsis thaliana mutants known to be deficient in putative EGase homologs. Switchgrass containing an overexpression of the EGase was compared to wildtype switchgrass via histology and microscopy. The confirmation of a functional EGase from switchgrass may aid in the development of switchgrass transformants with an amorphous cellulose structure, thereby reducing the amount of resources required during biofuel refinery

Aerosol major ion record at Mount Washington

This study examined the seasonal cycles and regional-scale meteorological controls on the chemical properties of bulk aerosols collected from 1999 to 2004 at Mount Washington, the highest peak in the northeastern United States. The concentrations of NH4+ and SO42− peaked during summer months. The pattern for aerosol NO3− was more complicated with relatively high median concentrations characterizing spring and summer months, but with major elevated events occurring during fall, winter, and spring. The seasonal relationship between NH4+ and SO42− indicated that during warmer months a mixture of (NH4)2SO4 and NH4HSO4 was present, while it was mainly the latter in winter. More acidity and higher concentrations of the major species were generally associated with winds from the southwest and west sectors. The highest (≥95th percentile) concentrations of SO42− and NH4+ were associated with air mass transport from major upwind source regions in the Midwest and along the eastern seaboard. The ionic composition and seasonal cycle observed at Mount Washington were similar to those measured at other northeastern sites, but the range and average concentrations were much lower. These differences were exaggerated during wintertime. Included in this paper are several Eulerian case studies of SO2 conversion to SO42− during transit from Whiteface Mountain, New York, to Mount Washington. The calculations suggest a gas-phase SO2 oxidation rate of ∼1–2% per hour and demonstrate the possibility of using these two sites to investigate the chemical evolution of air masses as they move from Midwestern source regions to northern New England

Neutrino Emission from Magnetized Proto-Neutron Stars in Relativistic Mean Field Theory

We make a perturbative calculation of neutrino scattering and absorption in hot and dense hyperonic neutron-star matter in the presence of a strong magnetic field. We find that the absorption cross-sections show a remarkable angular dependence in that the neutrino absorption strength is reduced in a direction parallel to the magnetic field and enhanced in the opposite direction. This asymmetry in the neutrino absorbtion can be as much as 2.2 % of the entire neutrino momentum for an interior magnetic field of \sim 2 x 10^{17} G. We estimate the pulsar kick velocities associated with this asymmetry in a fully relativistic mean-field theory formulation. We show that the kick velocities calculated here are comparable to observed pulsar velocities.Comment: arXiv admin note: substantial text overlap with arXiv:1009.097

Optimizing the process of product development by collaborating & thinking visually-co-creation within Howden

The paper explores the process of creating a bespoke New Product Development Procedure for the heavy engineering firm Howden through a collaborative Knowledge Transfer Partnership with the University of Strathclyde. The act of transferring knowledge was done by using a visual methodology and the paper explores the reasoning behind why using this methodology was so successful