Children\u27s after-school activity : associations with weight status and family circumstance

This study investigated children\u27s after-school activity and associations with body mass index (BMI) and family circumstance. One thousand two hundred thirty-four parents and 854 children (age 8-13 years) completed activity diaries for the 2 hours after school. Parents reported children as more active than children reported themselves. Boys were reported to be more active than girls. Activity levels were generally not associated with BMI or family circumstance with the exception of cultural background. Parent-reported mean child METs were higher for mothers born in Australia (3.3 vs. 3.0; p = .02). Child-reported mean METs were higher for fathers born in Australia (2.9 vs. 2.6; p = .04) and where English was their main language (2.9 vs. 2.3, p = .003).<br /

Theory or not theory? That is the question.

<p>Today, millions of bytes of data are generated in fractions of seconds, through sensors, network devices, web pages clicks and other sources. To handle this massive online data almost in real time is necessary to use scalable distributed systems whose components are fault tolerant, without compromising much performance.<br>The aim of this short course is to present this new class of distributed system and the challenges of its implementation for undergraduate and graduate students, or professionals interested in learning stream computing paradigm.</p

Spatio-temporal self-focusing in femtosecond pulse transmission through multimode optical fibers

We numerically investigate ultra-short pulse propagation in multimode optical fibers with launch peak powers approaching the critical power for self-focusing using a generalized multimode nonlinear Schrödinger equation approach. Nonlinear spatial and temporal effects combined with fiber dispersion govern pulse compression in space and time which can result in damage inducing intensity levels. Here we identify pulse parameters for which damage is avoided and high-power delivery through optical fiber is possible near the fiber zero-dispersion wavelength

Modal decomposition of self-focusing effects in optical fibres

When an intense beam with a transverse intensity gradient propagates in a medium with positive Kerr nonlinearity n2, the induced refractive index profile actuates a lens, focusing the beam itself. For input powers above a critical threshold, P &gt; Pcrit, self-focusing can subjugate beam divergence, resulting in catastrophic collapse and material failure [1]. For P &lt; Pcrit diffraction deflects energy from the focal point, and in a fibre, divergence is reflected at the core/cladding boundary instigating a periodic transverse beam profile

Games for health & mHealth apps for police & blue light personnel: A research review

Previous research has reported adverse health outcomes for emergency services personnel (ESP), outcomes that research more broadly has shown can be improved using a gamification and mobile health (mhealth) apps approach. We conducted a review of research on gamification and mhealth apps for ESP that had been published in the last 19 years using 6 major research databases. The results demonstrated that virtually no relevant research has been published, suggesting a significant gap in the evidence base of an approach that could potentially have significant benefits for the health of ESP

Stability of television viewing and electronic game/computer use in a prospective cohort study of Australian children: relationship with body mass index

BackgroundWhile much cross-sectional data is available, there have been few longitudinal investigations of patterns of electronic media use in children. Further, the possibility of a bi-directional relationship between electronic media use and body mass index in children has not been considered. This study aimed to describe longitudinal patterns of television viewing and electronic game/computer use, and investigate relationships with body mass index (BMI).MethodsThis prospective cohort study was conducted in elementary schools in Victoria, Australia. 1278 children aged 5&ndash;10 years at baseline and 8&ndash;13 years at follow-up had their BMI calculated, from measured height and weight, and transformed to z-scores based on US 2000 growth data. Weight status (non-overweight, overweight and obese) was based on international BMI cut-off points. Weekly television viewing and electronic game/computer use were reported by parents, these were summed to generate total weekly screen time. Children were classified as meeting electronic media use guidelines if their total screen time was &le;14 hrs/wk.ResultsElectronic media use increased over the course of the study; 40% met guidelines at baseline but only 18% three years later. Television viewing and electronic game/computer use tracked moderately and total screen time was positively associated with adiposity cross-sectionally. While weaker relationships with adiposity were observed longitudinally, baseline z-BMI and weight status were positively associated with follow-up screen time and baseline screen time was positively associated with z-BMI and weight status at follow-up. Children who did not meet guidelines at baseline had significantly higher z-BMI and were more likely to be classified as overweight/obese at follow-up.ConclusionElectronic media use in Australian elementary school children is high, increases with age and tracks over time. There appears to be a bi-directional association suggesting that interventions targeting reductions in either screen time or adiposity may have a positive effect on both screen time and adiposity.<br /

Effects of reproductive and demographic changes on breast cancer incidence in China: A modeling analysis

Background: Breast cancer incidence is currently low in China. However, the distribution of reproductive and lifestyle risk factors for breast cancer among Chinese women is changing rapidly. We quantified the expected effect of changes in breast cancer risk factors on future rates of breast cancer in China. Methods: We first validated and calibrated the Rosner-Colditz log-incidence breast cancer model in Chinese women who participated in the Shanghai Women's Health Study cohort (N = 74 942). We then applied the calibrated model to a representative sample of Chinese women who were aged 35-49 years in 2001 using data from the Chinese National Family Planning and Reproductive Health Survey (NFPRHS, N = 17 078) to predict the age-specific and cumulative breast cancer incidence among all Chinese women of this age group. We evaluated the relative impact of changes in modifiable risk factors, including alcohol intake, parity, postmenopausal hormone use, and adult weight gain, on cumulative incidence of breast cancer. Results: Breast cancer incidence in China is expected to increase substantially from current rates, estimated at 10-60 cases per 100 000 women, to more than 100 new cases per 100 000 women aged 55-69 years by 2021. We predicted 2.5 million cases of breast cancer by 2021 among Chinese women who were 35-49 years old in 2001. Modest reductions in hormone and alcohol use, and weight maintenance could prevent 270 000 of these cases. Conclusions: China is on the cusp of a breast cancer epidemic. Although some risk factors associated with economic development are largely unavoidable, the substantial predicted increase in new cases of breast cancer calls for urgent incorporation of this disease in future health care infrastructure planning

New pleiotropic effects of eliminating a rare tRNA from Streptomyces coelicolor, revealed by combined proteomic and transcriptomic analysis of liquid cultures

Background: In Streptomyces coelicolor, bldA encodes the only tRNA for a rare leucine codon, UUA. This tRNA is unnecessary for growth, but is required for some aspects of secondary metabolism and morphological development. We describe a transcriptomic and proteomic analysis of the effects of deleting bldA on cellular processes during submerged culture: conditions relevant to the industrial production of antibiotics. Results: At the end of rapid growth, a co-ordinated transient up-regulation of about 100 genes, including many for ribosomal proteins, was seen in the parent strain but not the ΔbldA mutant. Increased basal levels of the signal molecule ppGpp in the mutant strain may be responsible for this difference. Transcripts or proteins from a further 147 genes classified as bldA-influenced were mostly expressed late in culture in the wild-type, though others were significantly transcribed during exponential growth. Some were involved in the biosynthesis of seven secondary metabolites; and some have probable roles in reorganising metabolism after rapid growth. Many of the 147 genes were "function unknown", and may represent unknown aspects of Streptomyces biology. Only two of the 147 genes contain a TTA codon, but some effects of bldA could be traced to TTA codons in regulatory genes or polycistronic operons. Several proteins were affected posttranslationally by the bldA deletion. There was a statistically significant but weak positive global correlation between transcript and corresponding protein levels. Different technical limitations of the two approaches were a major cause of discrepancies in the results obtained with them. Conclusion: Although deletion of bldA has very conspicuous effects on the gross phenotype, the bldA molecular phenotype revealed by the "dualomic" approach has shown that only about 2% of the genome is affected; but this includes many previously unknown effects at a variety of different levels, including post translational changes in proteins and global cellular physiology