13,815 research outputs found
Elegy to My Eyes
This elegiac poem focuses on the speaker\u27s limited eyesight as she wakes up in the morning after letting her contacts dry up overnight
A Study on Agreement in PICO Span Annotations
In evidence-based medicine, relevance of medical literature is determined by
predefined relevance conditions. The conditions are defined based on PICO
elements, namely, Patient, Intervention, Comparator, and Outcome. Hence, PICO
annotations in medical literature are essential for automatic relevant document
filtering. However, defining boundaries of text spans for PICO elements is not
straightforward. In this paper, we study the agreement of PICO annotations made
by multiple human annotators, including both experts and non-experts.
Agreements are estimated by a standard span agreement (i.e., matching both
labels and boundaries of text spans), and two types of relaxed span agreement
(i.e., matching labels without guaranteeing matching boundaries of spans).
Based on the analysis, we report two observations: (i) Boundaries of PICO span
annotations by individual human annotators are very diverse. (ii) Despite the
disagreement in span boundaries, general areas of the span annotations are
broadly agreed by annotators. Our results suggest that applying a standard
agreement alone may undermine the agreement of PICO spans, and adopting both a
standard and a relaxed agreements is more suitable for PICO span evaluation.Comment: Accepted in SIGIR 2019 (Short paper
Impoliteness Strategies Used on Online Comments in an Indonesian Football Website
This research investigates linguistic impoliteness used in online football comments through the examination of impoliteness strategies proposed by Jonathan Culpeper. It examines how impoliteness strategies are used on online comments and what strategy mostly used by Indonesian participants in Okezone, an Indonesian football website. The research uses descriptive qualitative method supported by quantitative data. First, the writer found that Indonesian participants mostly used positive impoliteness strategy to express their negative attitude on giving comments. Second, there are four out of five impoliteness strategies used by Indonesian participants. Withhold politeness strategy is excluded
Analytical and experimental study of boiler instabilities due to feed-system - Subcooled region coupling
Instabilities occurring in forced-flow, electrically heated, downflow boiler due to feed system-subcooled region couplin
Field-Induced Breakup of Emulsion Droplets Stabilized by Colloidal Particles
We simulate the response of a particle-stabilized emulsion droplet in an
external force field, such as gravity, acting equally on all particles. We
show that the field strength required for breakup (at fixed initial area
fraction) decreases markedly with droplet size, because the forces act
cumulatively, not individually, to detach the interfacial particles. The
breakup mode involves the collective destabilization of a solidified particle
raft occupying the lower part of the droplet, leading to a critical force per
particle that scales approximately as .Comment: 4 pages, plus 3 pages of supplementary materia
A pharmacological cocktail for arresting actin dynamics in living cells.
The actin cytoskeleton is regulated by factors that influence polymer assembly, disassembly, and network rearrangement. Drugs that inhibit these events have been used to test the role of actin dynamics in a wide range of cellular processes. Previous methods of arresting actin rearrangements take minutes to act and work well in some contexts, but can lead to significant actin reorganization in cells with rapid actin dynamics, such as neutrophils. In this paper, we report a pharmacological cocktail that not only arrests actin dynamics but also preserves the structure of the existing actin network in neutrophil-like HL-60 cells, human fibrosarcoma HT1080 cells, and mouse NIH 3T3 fibroblast cells. Our cocktail induces an arrest of actin dynamics that initiates within seconds and persists for longer than 10 min, during which time cells maintain their responsivity to external stimuli. With this cocktail, we demonstrate that actin dynamics, and not simply morphological polarity or actin accumulation at the leading edge, are required for the spatial persistence of Rac activation in HL-60 cells. Our drug combination preserves the structure of the existing cytoskeleton while blocking actin assembly, disassembly, and rearrangement, and should prove useful for investigating the role of actin dynamics in a wide range of cellular signaling contexts
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