Enzymuria in Streptozotocin-Diabetic Rats

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Recommendation for the Measurement of “Alanine Aminopeptidase” in Urine

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AIMS - A new tool for stellar parameter determinations using asteroseismic constraints

A key aspect in the determination of stellar properties is the comparison of observational constraints with predictions from stellar models. Asteroseismic Inference on a Massive Scale (AIMS) is an open source code that uses Bayesian statistics and a Markov Chain Monte Carlo approach to find a representative set of models that reproduce a given set of classical and asteroseismic constraints. These models are obtained by interpolation on a pre-calculated grid, thereby increasing computational efficiency. We test the accuracy of the different operational modes within AIMS for grids of stellar models computed with the Li\`ege stellar evolution code (main sequence and red giants) and compare the results to those from another asteroseismic analysis pipeline, PARAM. Moreover, using artificial inputs generated from models within the grid (assuming the models to be correct), we focus on the impact on the precision of the code when considering different combinations of observational constraints (individual mode frequencies, period spacings, parallaxes, photospheric constraints,...). Our tests show the absolute limitations of precision on parameter inferences using synthetic data with AIMS, and the consistency of the code with expected parameter uncertainty distributions. Interpolation testing highlights the significance of the underlying physics to the analysis performance of AIMS and provides caution as to the upper limits in parameter step size. All tests demonstrate the flexibility and capability of AIMS as an analysis tool and its potential to perform accurate ensemble analysis with current and future asteroseismic data yields.Comment: Accepted for publication in MNRAS. 17 pages, 17 figure

A Modified Progressive Supranuclear Palsy Rating Scale

Background: The Progressive Supranuclear Palsy Rating Scale is a prospectively validated physician-rated measure of disease severity for progressive supranuclear palsy. We hypothesized that, according to experts' opinion, individual scores of items would differ in relevance for patients' quality of life, functionality in daily living, and mortality. Thus, changes in the score may not equate to clinically meaningful changes in the patient's status. Objective: The aim of this work was to establish a condensed modified version of the scale focusing on meaningful disease milestones. Methods: Sixteen movement disorders experts evaluated each scale item for its capacity to capture disease milestones (0 = no, 1 = moderate, 2 = severe milestone). Items not capturing severe milestones were eliminated. Remaining items were recalibrated in proportion to milestone severity by collapsing across response categories that yielded identical milestone severity grades. Items with low sensitivity to change were eliminated, based on power calculations using longitudinal 12-month follow-up data from 86 patients with possible or probable progressive supranuclear palsy. Results: The modified scale retained 14 items (yielding 0–2 points each). The items were rated as functionally relevant to disease milestones with comparable severity. The modified scale was sensitive to change over 6 and 12 months and of similar power for clinical trials of disease-modifying therapy as the original scale (achieving 80% power for two-sample t test to detect a 50% slowing with n = 41 and 25% slowing with n = 159 at 12 months). Conclusions: The modified Progressive Supranuclear Palsy Rating Scale may serve as a clinimetrically sound scale to monitor disease progression in clinical trials and routine

Upstream Supply Chain Visibility and Complexity Effect on Focal Company’s Sustainable Performance: Indian Manufacturers’ Perspective

Understanding supply chain sustainability performance is increasingly important for supply chain researchers and managers. Literature has considered supply chain sustainability and the antecedents of performance from a triple bottom line (economic, social, and environmental) perspective. However, the role of supply chain visibility and product complexity contingency in achieving sustainable supply chain performance has not been explored in depth. To address this gap, this study utilizes a contingent resource-based view theory perspective to understand the role of product complexity in shaping the relationship between upstream supply chain visibility (resources and capabilities) and the social, environmental, and economic performance dimensions. We develop and test a theoretical model using survey data gathered from 312 Indian manufacturing organizations. Our findings indicate that supply chain visibility (SCV) has significant influence on social and environmental performance under the moderation effect of product complexity. Hence, the study makes significant contribution to the extant literature by examining the impact of SCV under moderating effect of product complexity on social performance and environmental performance

Enzymuria of the Rat: The Preparation of Urine for Enzyme Analysis

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Automatische Bestimmung von Enzymaktivitäten in tierischen Seren mit dem Reaction Rate Analyzer 8600. 2. Mitteilung: Vergleiche der automatisierten mit der manuellen Methode an Glutamat-Dehydrogenase, Sorbit-Dehydrogenase, Leucin-Aminopeptidase und alkalischer Phosphatase

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Automatische Bestimmung von Enzymaktivitäten in tierischen Seren mit dem Reaction Rate Analyzer 8600. 1. Mitteilung: Vergleiche der automatisierten mit der manuellen Methode an Transaminasen, Lactatdehydrogenase und LDH-Isoenzym (α-HBDH)

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