The German-Czech Border Region after the Fall of the Iron Curtain : Effects on the Labour Market

Using the IAB Employment Sample (IABS) covering 1980-2001 we investigate what impact the fall of the Iron Curtain has had on the skill structure of employment and wages in the western German districts neighbouring the Czech Republic. The introduction of free trade in this region, which has one of the world´s largest spatial wage differentials, can be seen as a natural experiment. We presume that changes in skill and wage structures are particularly apparent in the regions situated immediately on the open border. Distinguishing three skill categories we obtain unexpected results. Though we observe a general shift from low-skilled jobs towards skilled jobs and a convergence trend of border regions towards the national average, we do not find a special effect for the period after the opening of the border, neither concerning the skill structure nor the wage differentials. -- Unter Verwendung von Daten der IAB-Regionalstichprobe (IABS) untersuchen wir, ob nach dem Fall des Eisernen Vorhangs Qualifizierungstrends und Lohnentwicklung in den bayerischen Grenzregionen zu Tschechien signifikante Unterschiede im Vergleich mit der Entwicklung auf aggregierter staatlicher Ebene aufweisen. Der Trend zu höherer Qualifizierung sowie der Trend zu höheren relativen Löhnen für besser Qualifizierte sollten dort überdurchschnittlich messbar sein. Unsere Resultate können einen speziellen Grenzöffnungseffekt jedoch weder bei der Qualifikationsstruktur noch bei der relativen Lohnentwicklung in der Grenzregion feststellen.border regions,international trade,employment,wage inequality

The German-Czech border region after the fall of the Iron Curtain: Effects on the labour market : an empirical study using the IAB Employment Sample (IABS)

"Using the IAB Employment Sample (IABS) covering 1980-2001 we investigate what impact the fall of the Iron Curtain has had on the skill structure of employment and wages in the western German districts neighbouring the Czech Republic. The introduction of free trade in this region, which has one of the world's largest spatial wage differentials, can be seen as a natural experiment. We presume that changes in skill and wage structures are particularly apparent in the regions situated immediately on the open border. Distinguishing three skill categories we obtain unexpected results. Though we observe a general shift from low-skilled jobs towards skilled jobs and a convergence trend of border regions towards the national average, we do not find a special effect for the period after the opening of the border, neither concerning the skill structure nor the wage differentials." (Author's abstract, IAB-Doku) ((en))Grenzgebiet, Qualifikationsstruktur, Lohnhöhe, osteuropäischer Transformationsprozess - Auswirkungen, IAB-Beschäftigtenstichprobe, Bayern, Tschechische Republik, Bundesrepublik Deutschland

The German-Czech Border Region after the Fall of the Iron Curtain : Effects on the Labour Market

Using the IAB Employment Sample (IABS) covering 1980-2001 we investigate what impact the fall of the Iron Curtain has had on the skill structure of employment and wages in the western German districts neighbouring the Czech Republic. The introduction of free trade in this region, which has one of the world´s largest spatial wage differentials, can be seen as a natural experiment. We presume that changes in skill and wage structures are particularly apparent in the regions situated immediately on the open border. Distinguishing three skill categories we obtain unexpected results. Though we observe a general shift from low-skilled jobs towards skilled jobs and a convergence trend of border regions towards the national average, we do not find a special effect for the period after the opening of the border, neither concerning the skill structure nor the wage differentials.Unter Verwendung von Daten der IAB-Regionalstichprobe (IABS) untersuchen wir, ob nach dem Fall des Eisernen Vorhangs Qualifizierungstrends und Lohnentwicklung in den bayerischen Grenzregionen zu Tschechien signifikante Unterschiede im Vergleich mit der Entwicklung auf aggregierter staatlicher Ebene aufweisen. Der Trend zu höherer Qualifizierung sowie der Trend zu höheren relativen Löhnen für besser Qualifizierte sollten dort überdurchschnittlich messbar sein. Unsere Resultate können einen speziellen Grenzöffnungseffekt jedoch weder bei der Qualifikationsstruktur noch bei der relativen Lohnentwicklung in der Grenzregion feststellen

The German-Czech border region after the fall of the Iron Curtain: Effects on the labour market. An empirical study using the IAB Employment Sample (IABS)

Using the IAB Employment Sample (IABS) covering 1980-2001 we investigate what impact the fall of the Iron Curtain has had on the skill structure of employment and wages in the western German districts neighbouring the Czech Republic. The introduction of free trade in this region, which has one of the world's largest spatial wage differentials, can be seen as a natural experiment. We presume that changes in skill and wage structures are particularly apparent in the regions situated immediately on the open border. Distinguishing three skill categories we obtain unexpected results. Though we observe a general shift from low-skilled jobs towards skilled jobs and a convergence trend of border regions towards the national average, we do not find a special effect for the period after the opening of the border, neither concerning the skill structure nor the wage differentials

The German-Czech border region after the fall of the Iron Curtain: effects on the labour market ; an empirical study using the IAB Employment Sample (IABS)

Unter Verwendung der Daten der IAB-Beschäftigtenstichprobe der Jahre 1980-2001 wird untersucht, welchen Einfluss das Fallen des Eisernen Vorhangs auf die Qualifikationsstruktur der Beschäftigten und die Löhne in den westdeutschen Gebieten hatte, die an die Tschechische Republik grenzen. Die Einführung des freien Handels in dieser Region, die eine der weltweit größten regionalen Lohndifferentiale aufweist, kann als natürliches Experiment betrachtet werden. Die Autoren vermuten, dass der Wandel in den Qualifikations- und Lohnstrukturen besonders in den Regionen stattfand, die unmittelbar an der nun offenen Grenze lagen. Bei der Betrachtung dreier Qualifikationsstufen erhalten die Autoren unerwartete Resultate. Obwohl sie eine generelle Verlagerung von niedrig qualifizierten Jobs zu qualifizierten Jobs und einen Konvergenztrend von Grenzregionen gegenüber der gesamten Nation beobachten, finden sie keine speziellen Effekte für die Periode nach der Grenzöffnung im Hinblick auf die Qualifikationsstruktur und die Lohndifferenzierung. (IAB)"Using the IAB Employment Sample (IABS) covering 1980-2001 we investigate what impact the fall of the Iron Curtain has had on the skill structure of employment and wages in the western German districts neighbouring the Czech Republic. The introduction of free trade in this region, which has one of the world's largest spatial wage differentials, can be seen as a natural experiment. We presume that changes in skill and wage structures are particularly apparent in the regions situated immediately on the open border. Distinguishing three skill categories we obtain unexpected results. Though we observe a general shift from low-skilled jobs towards skilled jobs and a convergence trend of border regions towards the national average, we do not find a special effect for the period after the opening of the border, neither concerning the skill structure nor the wage differentials." (author's abstract

Selective TEMPO-oxidation of alcohols to aldehydes in alternative organic solvents

Hinzmann A, Stricker M, Busch J, Glinski S, Oike K, Gröger H. Selective TEMPO-oxidation of alcohols to aldehydes in alternative organic solvents. European Journal of Organic Chemistry. 2020;(16):2399-2408.The TEMPO‐catalyzed oxidation of alcohols to aldehydes has emerged to one of the most widely applied methodologies for such transformations. Advantages are the utilization of sodium hypochlorite, a component of household bleach, as an oxidation agent and the use of water as a co‐solvent. However, a major drawback of this method is the often occurring strict limitation to use dichloromethane as an organic solvent in a biphasic reaction medium with water. Previous studies show that dichloromethane cannot easily be substituted because a decrease of selectivity or inhibition of the reaction is observed by using alternative organic solvents. Thus, up to now, only a few examples are known in which after a tedious optimization of the reaction dichloromethane could be replaced. In order to overcome the current limitations, we were interested in finding a TEMPO‐oxidation method in alternative organic solvents, which is applicable for various alcohol oxidations. As a result, we found a method for N‐oxyl radical‐catalyzed oxidation using sodium hypochlorite as an oxidation agent in nitriles as an organic solvent component instead of dichloromethane. Besides the oxidation of aromatic primary alcohols also aliphatic primary alcohols, secondary alcohols as well as dialcohols were successfully converted when using this method, showing high selectivity towards the carbonyl compound and low amounts of the acid side‐product

3D Nanolithography by Means of Lipid Ink Spreading Inhibition

While patterning 2D metallic nanostructures are well established through different techniques, 3D printing still constitutes a major bottleneck on the way to device miniaturization. In this work a fluid phase phospholipid ink is used as a building block for structuring with dip-pen nanolithography. Following a bioinspired approach that relies on ink-spreading inhibition, two processes are presented to build 2D and 3D metallic structures. Serum albumin, a widely used protein with an innate capability to bind to lipids, is the key in both processes. Covering the sample surface with it prior to lipid writing, anchors lipids on the substrate, which ultimately allows the creation of highly stable 3D lipid-based scaffolds to build metallic structures. © 2022 The Authors. Small published by Wiley-VCH GmbH.E.B. acknowledges the Karlsruhe Institute of Technology for a postdoctoral fellowship in the frame of the YIG Prep Pro program and the Spanish Ministry of Science for a Juan de la Cierva Incorporation fellowship. This work was carried out with the support of the Karlsruhe Nano Micro Facility (KNMF, www.knmf.kit.edu), a Helmholtz Research Infrastructure at Karlsruhe Institute of Technology (KIT, www.kit.edu). M.H. acknowledges additional support by the Helmholtz Association in the form of a Helmholtz ERC Recognition Award.Peer reviewe

Comparison of cardiac, hepatic, and renal effects of arginine vasopressin and noradrenaline during porcine fecal peritonitis: a randomized controlled trial

INTRODUCTION: Infusing arginine vasopressin (AVP) in vasodilatory shock usually decreases cardiac output and thus systemic oxygen transport. It is still a matter of debate whether this vasoconstriction impedes visceral organ blood flow and thereby causes organ dysfunction and injury. Therefore, we tested the hypothesis whether low-dose AVP is safe with respect to liver, kidney, and heart function and organ injury during resuscitated septic shock. METHODS: After intraperitoneal inoculation of autologous feces, 24 anesthetized, mechanically ventilated, and instrumented pigs were randomly assigned to noradrenaline alone (increments of 0.05 microg/kg/min until maximal heart rate of 160 beats/min; n = 12) or AVP (1 to 5 ng/kg/min; supplemented by noradrenaline if the maximal AVP dosage failed to maintain mean blood pressure; n = 12) to treat sepsis-associated hypotension. Parameters of systemic and regional hemodynamics (ultrasound flow probes on the portal vein and hepatic artery), oxygen transport, metabolism (endogenous glucose production and whole body glucose oxidation derived from blood glucose isotope and expiratory 13CO2/12CO2 enrichment during 1,2,3,4,5,6-13C6-glucose infusion), visceral organ function (blood transaminase activities, bilirubin and creatinine concentrations, creatinine clearance, fractional Na+ excretion), nitric oxide (exhaled NO and blood nitrate + nitrite levels) and cytokine production (interleukin-6 and tumor necrosis factor-alpha blood levels), and myocardial function (left ventricular dp/dtmax and dp/dtmin) and injury (troponin I blood levels) were measured before and 12, 18, and 24 hours after peritonitis induction. Immediate post mortem liver and kidney biopsies were analysed for histomorphology (hematoxylin eosin staining) and apoptosis (TUNEL staining). RESULTS: AVP decreased heart rate and cardiac output without otherwise affecting heart function and significantly decreased troponin I blood levels. AVP increased the rate of direct, aerobic glucose oxidation and reduced hyperlactatemia, which coincided with less severe kidney dysfunction and liver injury, attenuated systemic inflammation, and decreased kidney tubular apoptosis. CONCLUSIONS: During well-resuscitated septic shock low-dose AVP appears to be safe with respect to myocardial function and heart injury and reduces kidney and liver damage. It remains to be elucidated whether this is due to the treatment per se and/or to the decreased exogenous catecholamine requirements

CAAP48, a New Sepsis Biomarker, Induces Hepatic Dysfunction in an in vitro Liver-on-Chip Model

Sepsis is a leading cause of mortality in the critically ill, characterized by life-threatening organ dysfunctions due to dysregulation of the host response to infection. Using mass spectrometry, we identified a C-terminal fragment of alpha-1-antitrypsin, designated CAAP48, as a new sepsis biomarker that actively participates in the pathophysiology of sepsis. It is well-known that liver dysfunction is an early event in sepsis-associated multi-organ failure, thus we analyzed the pathophysiological function of CAAP48 in a microfluidic-supported in vitro liver-on-chip model. Hepatocytes were stimulated with synthetic CAAP48 and several control peptides. CAAP48-treatment resulted in an accumulation of the hepatocyte-specific intracellular enzymes aspartate- and alanine-transaminase and impaired the activity of the hepatic multidrug resistant-associated protein 2 and cytochrome P450 3A4. Moreover, CAAP48 reduced hepatic expression of the multidrug resistant-associated protein 2 and disrupted the endothelial structural integrity as demonstrated by reduced expression of VE-cadherin, F-actin and alteration of the tight junction protein zonula occludens-1, which resulted in a loss of the endothelial barrier function. Furthermore, CAAP48 induced the release of adhesion molecules and pro- and anti-inflammatory cytokines. Our results show that CAAP48 triggers inflammation-related endothelial barrier disruption as well as hepatocellular dysfunction in a liver-on-chip model emulating the pathophysiological conditions of inflammation. Besides its function as new sepsis biomarker, CAAP48 thus might play an important role in the development of liver dysfunction as a consequence of the dysregulated host immune-inflammatory response in sepsis