Acute parkinsonism due to transdermal methanol intoxication: First report = Akut parkinsonizmus transdermalis metanolmérgezés következtében: Első beszámoló

Introduction – Methanol is a colorless and highly toxic liquid similar to ethanol in odor and taste. Methanol intake can lead to severe metabolic acidosis, loss of vision, permanent neurological damage, and death. Case report – We report a case of a 19-year-old female patient who had no known disease history. A large portion of her back was covered in spirits for back pain and kept on for 2 days. Cranial magnetic resonance imaging (MRI) on the 5th day showed hyperintense pathologic signal changes in the T2 sequence without contrast enhancement in the bilateral frontal cortical- subcortical regions and basal ganglia. Following neurological examination of the patient, she was found to have bradymimia, marked resting tremor, bradykinesia, and dystonia on the right upper and lower extremities. Our case is important because it is the only case where parkinsonism developed as a result of acute transdermal methanol intoxication. | Bevezetés – A metanol színtelen és erősen mérgező folyadék, ami szagában és ízében az etanolhoz hasonló. A metanol bevitele súlyos metabolikus acidózishoz, látásvesztés- hez, maradandó neurológiai károsodáshoz és halálhoz vezethet. Esetismertetés – Egy 19 éves nőbeteg ese- téről számolunk be, akinek anamnézisében nem szerepelt semmilyen betegség. A hátának nagy részét hátfájás miatt alkohollal borítot- ták be, amit 2 napig rajtatartottak. A koponya mágneses rezonanciás képalkotása (MRI) az 5. napon a T2 szekvenciában kontrasztfokozódás nélküli hiperintenzív kóros jelváltozást mutatott a kétoldali frontális corticalis-subcorticalis régiókban és a bazális ganglionokban. A beteg neurológiai vizsgálatát követően a jobb felső és alsó végtagokon bradymimia, kifejezett nyugalmi tremor, bradykinesia és dystonia volt kimutatható. Esetünk azért fontos, mert ez az egyetlen olyan beszámoló, ami akut transdermalis metanolmérgezés következté- ben kialakult parkinsonizmust ismertet

Neutral-State Green Conjugated Polymers from Pyrrole Bis-Substituted Benzothiadiazole and Benzoselenadiazole for Electrochromic Devices

Two donor/acceptor/donor-type pyrrole-incorporated monomers, 4,7-di(1H-pyrrol-2-yl)benzo[c][1,2,5]thiadiazole (M1) and 4,7-di(1H-pyrrol-2-yl) benzo[c][1,2,5] selenadiazole (M2), were synthesized and polymerized electrochemically. The resulting polymers (P1 and P2) were investigated in terms of their electrochromic and optical properties. Spectroelectrochemistry studies revealed that both polymers show two distinct absorptions in both red and blue regions. The absorptions at around 400 and 700 nm correspond to neutral-state green polymers P1 and P2, which is a unique property for conjugated polymers. Optical band gaps were calculated as 1.12 and 1.08 eV for P1 and P2, respectively

Donor-acceptor type random copolymers for full visible light absorption

Copolymerization towards obtaining full visible light absorption is highlighted. Randomly distributed segments of different oligomers resulted in neutral state black copolymers. Solution processability and highly transmissive gray oxidized states make copolymers great candidates to be used in low cost flexible organic electronics

Cytotoxicity screening of Thymus vulgaris L. in breast cancer: in vitro study

Breast cancer is one of the leading causes of cancer-related deaths due to its aggressive course. There is an increasing need for alternative therapy strategies, including herbal medications, to treat the disease because of its high incidence. Medicinal plants, such as Thymus vulgaris L. (T. vulgaris), have recently attracted great interest due to the antitumor properties of their extracts. The purpose of this investigation was to ascertain whether T. vulgaris had any cytotoxic effects on two different breast cancer cell lines. MTT test was applied to evaluate the effect of T. vulgaris on cell viability. TUNEL method was used to determine its apoptotic effect. LC3 and Beclin-1 expression levels were determined by immunofluorescence staining method and its autophagic effect was evaluated. Our findings demonstrate that T. vulgaris greately lowers proliferation, both in terms of concentration and duration. Consistent with decreased proliferation, an increase in apoptotic and autophagic cell death were also observed. The migration capacity of MCF-7 and MDA-MB-231 breast cancer cells was greatly suppressed by T. vulgaris, while significantly reducing colony formation. This study is the first to look into how T. vulgaris methanol extract affects breast cancer cells. All of these findings demonstrate that T. vulgaris prevents breast cancer cells from developing a malignant phenotype. It is possible to say that the methanol extract of T. vulgaris is suitable for the treatment of breast cancer, including aggressive types. However, in vivo research should support these results

Evaluation of Epicardial Fat Thickness in Young Patients With Embolic Stroke of Undetermined Source

WOS: 000457779200001PubMed ID: 29953033Objectives:Epicardial adipose tissue is metabolically active and is an important predictor of metabolic and cardiovascular diseases. This study investigated the echocardiographic epicardial adipose tissue measurement in young patients with embolic stroke of undetermined source (ESUS).Materials and Methods:We studied 77 volunteers, including 40 patients with ESUS (mean age 438y, 16 female patients) and 37 healthy subjects (mean age 387y, 20 female subjects). All necessary biochemical parameters were analyzed, and epicardial fat thickness (EFT) was measured by echocardiography in all subjects. Additional related diagnostic work-up was conducted in each patient, according to the patients' clinical presentation.Results:The patients with ESUS had a significantly higher EFT than the control group (5.51 +/- 0.82 vs. 3.96 +/- 0.51; P<0.01). Furthermore, there was a positive correlation between EFT and serum C-reactive protein levels (r=0.284; P<0.05). As an optimal cut-off point, a high-risk EFT value of 4.6mm was determined to predict ESUS, with an 87.5% sensitivity and an 81.1% specificity.Conclusion:We found that echocardiographic EFT was significantly higher in young patients with ESUS than in healthy individuals. Increased EFT might be a novel risk factor in these patient

Evaluation of Cognitive Functions in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: A Prospective Pilot Study

Purpose: It is not clear whether cognitive functions are impaired in young patients with acute coronary syndrome (ACS). This study aims to detect whether or not there is cognitive impairment and cerebral changes in young patients with ACS undergoing percutaneous coronary intervention (PCI). Patients and Methods: All 50 patients with ACS who were treated with primary PCI were eligible for this prospective study. All participants had normal cognitive function before ACS. Brain magnetic resonance imaging (MRI) was performed to quantify changes in brain white and gray matter. Cognitive functions (CFs) were evaluated by seven cognitive tests. Patients were categorized by MRI findings and test scores were compared from the first day to after the first month. Results: We determined 25 patients with impaired CFs on the first day. After the first month, we identified 18 patients with transient impaired CFs. No structural difference was observed between impaired CF and normal CF. While 25 patients had a score of 1 according to Fazekas, 10 patients had a score of 1 according to MTLA. While the mean Stroop test completion time and Stroop test error rate scores were significantly higher on the first day than after the first month in the Fazekas+ group (p = 0.003, p p < 0.05). Conclusions: Patients with ACS have transient impairment in cognitive functions. Acute coronary syndrome is not associated with structural changes in the brain

Effect of baricity of low dose diluted bupivacaine with fentanyl on the duration and quality of spinal block in transurethral prostatectomy

Purpose: In this prospective randomized controlled trial, we investigated whether density of low dose diluted bupivacaine with fentanyl effects the duration and quality of the spinal block for transurethral prostatectomy (TURP) in elderly patients. Materials and Methods: Sixty patients requiring elective TURP were randomly allocated into two groups. Group H (n=30) received fentanyl 20 mcg+hyperbaric bupivacaine 0.5\% (1.5 ml)+ saline 1.1 ml. Group I (n=30) received fentanyl 20 mcg+ plain bupivacaine 0.5\% (1.5 ml)+ saline 1.1 ml in total, bupivacaine 0.25\% (3 ml) intrathecally. Onset, duration of the sensory block, the degree of motor block, perioperative anesthesia quality, side-effects, analgesic-free period were assessed. Results: The median peak level of the sensory block was significantly higher in Group H than in Group I. The time to the first analgesic request was longer in Group H). There were no differences between the groups for degree of the motor block, quality of anaesthesia, or adverse effects. Conclusion: Low-dose diluted hyperbaric bupivacaine with fentanyl provides adequate anaesthesia, postoperative analgesia without haemodynamic instability or prolonging the recovery time for TURP in elderly patients