103 research outputs found
Understanding the Impact of Early Citers on Long-Term Scientific Impact
This paper explores an interesting new dimension to the challenging problem
of predicting long-term scientific impact (LTSI) usually measured by the number
of citations accumulated by a paper in the long-term. It is well known that
early citations (within 1-2 years after publication) acquired by a paper
positively affects its LTSI. However, there is no work that investigates if the
set of authors who bring in these early citations to a paper also affect its
LTSI. In this paper, we demonstrate for the first time, the impact of these
authors whom we call early citers (EC) on the LTSI of a paper. Note that this
study of the complex dynamics of EC introduces a brand new paradigm in citation
behavior analysis. Using a massive computer science bibliographic dataset we
identify two distinct categories of EC - we call those authors who have high
overall publication/citation count in the dataset as influential and the rest
of the authors as non-influential. We investigate three characteristic
properties of EC and present an extensive analysis of how each category
correlates with LTSI in terms of these properties. In contrast to popular
perception, we find that influential EC negatively affects LTSI possibly owing
to attention stealing. To motivate this, we present several representative
examples from the dataset. A closer inspection of the collaboration network
reveals that this stealing effect is more profound if an EC is nearer to the
authors of the paper being investigated. As an intuitive use case, we show that
incorporating EC properties in the state-of-the-art supervised citation
prediction models leads to high performance margins. At the closing, we present
an online portal to visualize EC statistics along with the prediction results
for a given query paper
Surgeon’s perspective on rare yet potentially fatal complication of GI perforation following endoscopy
Gastrointestinal endoscopy plays an essential role in the diagnosis, staging, and treatment of pathologies of the GI tract. New-generation endoscopes, advanced imaging technologies, the introduction of new therapeutic devices into clinical practice, and modification of old techniques have expanded both the diagnostic and therapeutic armamentarium of the endoscopist. complications are rare with a rate of less than 1 per 5000 cases. perforations are either due to therapeutic dilatation, coagulation or passage of side viewing instrument into the duodenum. Here we present a case of 56 yr old male who underwent diagnostic endoscopy for peptic ulcer. I t lead to endoscope induced large duodenal perforation of about 10 cms in its long axis recognized at laparotomy 10 days after the intervention.it is important to mention the perforation was repaired surgically and patient developed no post operative complications. Undesired complications though rare, are potentially fatal and risks need to be evaluated before performing all endoscopic procedure
Unsupervised Learning of Visual Features by Contrasting Cluster Assignments
Unsupervised image representations have significantly reduced the gap with
supervised pretraining, notably with the recent achievements of contrastive
learning methods. These contrastive methods typically work online and rely on a
large number of explicit pairwise feature comparisons, which is computationally
challenging. In this paper, we propose an online algorithm, SwAV, that takes
advantage of contrastive methods without requiring to compute pairwise
comparisons. Specifically, our method simultaneously clusters the data while
enforcing consistency between cluster assignments produced for different
augmentations (or views) of the same image, instead of comparing features
directly as in contrastive learning. Simply put, we use a swapped prediction
mechanism where we predict the cluster assignment of a view from the
representation of another view. Our method can be trained with large and small
batches and can scale to unlimited amounts of data. Compared to previous
contrastive methods, our method is more memory efficient since it does not
require a large memory bank or a special momentum network. In addition, we also
propose a new data augmentation strategy, multi-crop, that uses a mix of views
with different resolutions in place of two full-resolution views, without
increasing the memory or compute requirements much. We validate our findings by
achieving 75.3% top-1 accuracy on ImageNet with ResNet-50, as well as
surpassing supervised pretraining on all the considered transfer tasks.Comment: NeurIPS 202
Extended-spectrum β-lactamase and AmpC β-lactamase Production among Gram-negative Bacilli Isolates Obtained from Urinary Tract Infections and Wound Infections
Extended-spectrum β-lactamases (ESBLs) and AmpC β-lactamases continue to be a major problem in healthcare settings. Due to the scarcity of information regarding the antibiotic susceptibility patterns particularly from urinary tract infection (UTI) and wound infections, the current study was carried out to assist the clinicians to prescribe appropriate antibiotics against Gram-negative clinical isolates. In the current study, urine (n = 620) and pus (n = 228) samples were collected from different sites (at various clinical departments) and subjected to direct microscopic examination, culture and antibiotic susceptibility testing (AST). In the AST testings, the isolates that exhibited reduced zone of inhibition to one or more of the antibiotics such as cefotaxime (≤27 mm), ceftriaxone (≤25 mm), ceftazidime (≤22 mm), cefpodoxime (≤17 mm) and aztreonam (≤27 mm) were considered as potential ESBL producers and the ESBL production was confirmed using phenotypic screening test (double-disk synergy test) and phenotypic confirmatory test (combined-disk test). However, isolates showing resistance or decreased sensitivity to cefoxitin, cefotaxime, ceftriaxone, ceftazidime, cefpodoxime or aztreonam and sensitive to cefepime were considered as a screen positive AmpC producer and subjected to AmpC disk tests. The current study concluded that 72.41% and 21.76% of ESBL and AmpC producers were detected, respectively in our hospital. It was also observed that the double-disk synergy and combined-disk tests were equally effective for ESBL detection. Further, AmpC disk test is simple, easy to perform and interpret, requiring less expertise for the rapid detection of AmpC isolates
Quantitative tissue proteome profile reveals neutrophil degranulation and remodeling of extracellular matrix proteins in early stage gallbladder cancer
Gallbladder cancer (GBC) is an aggressive malignancy of the gastrointestinal tract with a poor prognosis. It is important to understand the molecular processes associated with the pathogenesis of early stage GBC and identify proteins useful for diagnostic and therapeutic strategies. Here, we have carried out an iTRAQ-based quantitative proteomic analysis of tumor tissues from early stage GBC cases (stage I, n=7 and stage II, n=5) and non-tumor controls (n=6) from gallstone disease (GSD). We identified 357 differentially expressed proteins (DEPs) based on ≥ 2 unique peptides and ≥ 2 fold change with p value < 0.05. Pathway analysis using the STRING database showed, ‘neutrophil degranulation’ to be the major upregulated pathway that includes proteins such as MPO, PRTN3, S100A8, MMP9, DEFA1, AZU, and ‘ECM organization’ to be the major downregulated pathway that includes proteins such as COL14A1, COL1A2, COL6A1, COL6A2, COL6A3, BGN, DCN. Western blot and/or IHC analysis confirmed the elevated expression of MPO, PRTN3 and S100A8 in early stage of the disease. Based on the above results, we hypothesize that there is an increased neutrophil infiltration in tumor tissue and neutrophil degranulation leading to degradation of extracellular matrix (ECM) proteins promoting cancer cell invasion in the early stage GBC. Some of the proteins (MPO, MMP9, DEFA1) associated with ‘neutrophil degranulation’ showed the presence of ‘signal sequence’ suggesting their potential as circulatory markers for early detection of GBC. Overall, the study presents a protein dataset associated with early stage GBC
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