11 research outputs found
Acetaminophen (Paracetamol) Induces Hypothermia During Acute Cold Stress.
BACKGROUND
Acetaminophen is an over-the-counter drug used to treat pain and fever, but it has also been shown to reduce core temperature (T c) in the absence of fever. However, this side effect is not well examined in humans, and it is unknown if the hypothermic response to acetaminophen is exacerbated with cold exposure.
OBJECTIVE
To address this question, we mapped the thermoregulatory responses to acetaminophen and placebo administration during exposure to acute cold (10 °C) and thermal neutrality (25 °C).
METHODS
Nine healthy Caucasian males (aged 20-24Â years) participated in the experiment. In a double-blind, randomised, repeated measures design, participants were passively exposed to a thermo-neutral or cold environment for 120Â min, with administration of 20Â mg/kg lean body mass acetaminophen or a placebo 5Â min prior to exposure. T c, skin temperature (T sk), heart rate, and thermal sensation were measured every 10Â min, and mean arterial pressure was recorded every 30Â min. Data were analysed using linear mixed effects models. Differences in thermal sensation were analysed using a cumulative link mixed model.
RESULTS
Acetaminophen had no effect on T c in a thermo-neutral environment, but significantly reduced T c during cold exposure, compared with a placebo. T c was lower in the acetaminophen compared with the placebo condition at each 10-min interval from 80 to 120 min into the trial (all p  0.05).
CONCLUSION
This preliminary trial suggests that acetaminophen-induced hypothermia is exacerbated during cold stress. Larger scale trials seem warranted to determine if acetaminophen administration is associated with an increased risk of accidental hypothermia, particularly in vulnerable populations such as frail elderly individuals
Relationship between pretraining subjective wellness measures, player load, and rating-of-perceived-exertion training load in American college football
© 2018 Human Kinetics, Inc. Context: The relationship between pretraining subjective wellness and external and internal training load in American college football is unclear. Purpose: To examine the relationship of pretraining subjective wellness (sleep quality, muscle soreness, energy, wellness Z score) with player load and session rating of perceived exertion (s-RPE-TL) in American college football players. Methods: Subjective wellness (measured using 5-point, Likert-scale questionnaires), external load (derived from GPS and accelerometry), and s-RPE-TL were collected during 3 typical training sessions per week for the second half of an American college football season (8 wk). The relationship of pretraining subjective wellness with player load and s-RPE training load was analyzed using linear mixed models with a random intercept for athlete and a random slope for training session. Standardized mean differences (SMDs) denote the effect magnitude. Results: A 1-unit increase in wellness Z score and energy was associated with trivial 2.3% (90% confidence interval [CI] 0.5, 4.2; SMD 0.12) and 2.6% (90% CI 0.1, 5.2; SMD 0.13) increases in player load, respectively. A 1-unit increase in muscle soreness (players felt less sore) corresponded to a trivial 4.4% (90% CI ?8.4, ?0.3; SMD ?0.05) decrease in s-RPE training load. Conclusion: Measuring pretraining subjective wellness may provide information about players’ capacity to perform in a training session and could be a key determinant of their response to the imposed training demands American college football. Hence, monitoring subjective wellness may aid in the individualization of training prescription in American college football players