The Chemical Compositions Of RR Lyrae Type C Variable Stars

We present a detailed chemical abundance study of eight RR Lyrae variable stars of subclass c (RRc). The target RRc stars chosen for study exhibit "Blazhko-effect" period and amplitude modulations to their pulsational cycles. Data for this study were gathered with the echelle spectrograph of the 100 inch du Pont telescope at Las Campanas Observatory. Spectra were obtained throughout each star's pulsation cycle. Atmospheric parameters-effective temperature, surface gravity, microturbulent velocity, and metallicity-were derived at multiple phase points. We found metallicities and element abundance ratios to be constant within observational uncertainties over the pulsational cycles of all stars. Moreover, the alpha-element and Fe-group abundance ratios with respect to iron are consistent with other horizontal-branch members (RRab, blue and red non-variables). Finally, we have used the [Fe/H] values of these eight RRc stars to anchor the metallicity estimates of a large-sample RRc snapshot spectroscopic study being conducted with the same telescope and instrument combination employed here.NSF AST-0908978, AST-1211585Baker Centennial Research EndowmentJohn W. Cox Endowment for the Advanced Studies in AstronomyMcDonald Observator

Genetic landscape of 6089 inherited retinal dystrophies affected cases in Spain and their therapeutic and extended epidemiological implications

Inherited retinal diseases (IRDs), defined by dysfunction or progressive loss of photoreceptors, are disorders characterized by elevated heterogeneity, both at the clinical and genetic levels. Our main goal was to address the genetic landscape of IRD in the largest cohort of Spanish patients reported to date. A retrospective hospital-based cross-sectional study was carried out on 6089 IRD affected individuals (from 4403 unrelated families), referred for genetic testing from all the Spanish autonomous communities. Clinical, demographic and familiar data were collected from each patient, including family pedigree, age of appearance of visual symptoms, presence of any systemic findings and geographical origin. Genetic studies were performed to the 3951 families with available DNA using different molecular techniques. Overall, 53.2% (2100/3951) of the studied families were genetically characterized, and 1549 different likely causative variants in 142 genes were identified. The most common phenotype encountered is retinitis pigmentosa (RP) (55.6% of families, 2447/4403). The most recurrently mutated genes were PRPH2, ABCA4 and RS1 in autosomal dominant (AD), autosomal recessive (AR) and X-linked (XL) NON-RP cases, respectively; RHO, USH2A and RPGR in AD, AR and XL for non-syndromic RP; and USH2A and MYO7A in syndromic IRD. Pathogenic variants c.3386G > T (p.Arg1129Leu) in ABCA4 and c.2276G > T (p.Cys759Phe) in USH2A were the most frequent variants identified. Our study provides the general landscape for IRD in Spain, reporting the largest cohort ever presented. Our results have important implications for genetic diagnosis, counselling and new therapeutic strategies to both the Spanish population and other related populations.This work was supported by the Instituto de Salud Carlos III (ISCIII) of the Spanish Ministry of Health (FIS; PI16/00425 and PI19/00321), Centro de Investigación Biomédica en Red Enfermedades Raras (CIBERER, 06/07/0036), IIS-FJD BioBank (PT13/0010/0012), Comunidad de Madrid (CAM, RAREGenomics Project, B2017/BMD-3721), European Regional Development Fund (FEDER), the Organización Nacional de Ciegos Españoles (ONCE), Fundación Ramón Areces, Fundación Conchita Rábago and the University Chair UAM-IIS-FJD of Genomic Medicine. Irene Perea-Romero is supported by a PhD fellowship from the predoctoral Program from ISCIII (FI17/00192). Ionut F. Iancu is supported by a grant from the Comunidad de Madrid (CAM, PEJ-2017-AI/BMD7256). Marta del Pozo-Valero is supported by a PhD grant from the Fundación Conchita Rábago. Berta Almoguera is supported by a Juan Rodes program from ISCIII (JR17/00020). Pablo Minguez is supported by a Miguel Servet program from ISCIII (CP16/00116). Marta Corton is supported by a Miguel Servet program from ISCIII (CPII17/00006). The funders played no role in study design, data collection, data analysis, manuscript preparation and/or publication decisions

PRINCIPALES BACTERIAS GRAM (-) EN NEUMONIA TARDIA ASOCIADA A VENTILACION MECANICA, EN EL HGE “DR JOSE MA. RODRIGUEZ”

RESUMEN ANTECEDENTES: Las enfermedades nosocomiales son complicaciones comunes de la asistencia hospitalaria, una de ellas, la Neumonía Asociada a Ventilación Mecánica, si bien no es la más frecuente de ellas, es una de las que tiene mayor mortalidad de no ser tratada a tiempo, iniciar tratamiento empírico dependiendo de la microbiología especifica de nuestra unidad de trabajo es de vital importancia para disminuir los días de ventilación asistida, las posibles complicaciones a largo plazo así como la mortalidad, disminuyendo los costos tanto para los pacientes como para la institución en general. MATERIAL Y METODOS: Se realizó un estudio Observacional, Retrospectivo, Transversal, Analítico y Descriptivo. En base al estudio de 63 pacientes que se encontraron con el diagnostico de Neumonía Asociada a Ventilación Mecánica, ingresados en los servicios de Medicina Interna y Unidad de Cuidados Intensivos Adultos, realizando en todos ellos un cultivo de secreción bronquial, con agente GRAM Negativo, independientemente del diagnóstico de ingreso. RESULTADOS: En nuestra muestra de pacientes con Neumonía Asociada a Ventilación Mecánica, los agentes gram negativos más comunes asociados a esta patologia son en primer lugar Acinetobacter Baumannii con un 22.22%, seguido de Escherichia Coli en un 15.87% y en tercer lugar Pseudomonas aeruginosa con un 14.28%. RECOMENDACIONES: Todo paciente con ventilación mecánica invasiva, que exceda las 48 horas, con un score CPIS mayor a 6, se debe solicitar un cultivo de expectoración bronquial. Es de importancia el inicio de un manejo antibiotico empirico en base a las recomendaciones de las guias internacionales. Fomentar la creacion de estrategias estadarizadas para el tratamiento de la neumonia asociada a ventilacion mecanica

Towards the Integration of Emerging Technologies as Support for the Teaching and Learning Model in Higher Education

The pandemic caused by COVID-19 impacted the entire world, but the significant challenges to be faced during this crisis opened an opportunity for organizations to evolve toward a digital transformation. Educational institutions were a concrete example of the use of technologies, which were abruptly incorporated into the teaching–learning model. Although this initiative was initially a challenge for teachers and students, it has now become a tool for new innovative teaching models, such as hybrid, online, and flexible models. The impact of technology used in education has been beneficial due to emerging technologies (virtual reality, augmented reality, games, web applications, mobile applications, etc.), which have served as tools to facilitate and motivate studying. These educational trends contribute directly to the fourth Sustainable Development Goal (SDG). This research analyzes whether the use of a web application, as a support in the educational model, can make students better understand the subjects of network infrastructure and be more efficient when configuring equipment in a data network. Therefore, this research is based on the design of an educational web application based on Python libraries, which allows the configuration of networking equipment based on the concept of network automation with the application of a graphical user interface (GUI). The web application can be deployed with communication equipment or in conjunction with the GNS3 simulator. This versatility allows this web tool to be applied to the teaching of network equipment configuration in any mode of study (classroom, online, hybrid, or flexible). The results obtained in this research are encouraging and open the way for the implementation of network automation and Python libraries for educational applications that can be important tools within the teaching and learning models of higher education.This work was financed by the Universidad de Las Américas through project code: TIC.LCC.22.01

Predictors of hydrocephalus as a complication of non-traumatic subarachnoid hemorrhage: a retrospective observational cohort study in 107 patients

Abstract Background The predictors of shunt dependency such as amount of subarachnoid blood, acute hydrocephalus (HC), mode of aneurysm repair, clinical grade at admission and cerebro spinal fluid (CSF) drainage in excess of 1500 ml during the 1st week after the subarachnoid hemorrhage (SAH) have been identified as predictors of shunt dependency. Therefore our main objective is to identify predictors of CSF shunt dependency following non-traumatic subarachnoid hemorrhage. Methods We performed a retrospective study including patients from January 1st 2012 to September 30th 2014 between 16 and 89 years old and had a non-traumatic subarachnoid hemorrhage in cranial computed tomography (CCT). We excluded patients with the following characteristics: Patients who died 3 days after admittance, lesions in brainstem, previous surgical treatment in another clinic, traumatic brain injury, pregnancy and disability prior to SAH. We performed a descriptive and comparative analysis as well as a logistic regression with the variables that showed a significant difference (p < 0.05). Hence we identified the variables concerning HC after non traumatic SAH and its correlation. Results One hundred and seven clinical files of patients with non-traumatic SAH were analyzed. Twenty one (48%) later underwent shunt treatment. Shunt patients had significantly clinical and corroborated with doppler ultrasonography vasospasmus (p = 0.015), OR = 5.2. The amount of subarachnoidal blood according to modified Fisher grade was (p = 0.008) OR = 10.9. Endovascularly treated patients were less often shunted as compared with those undergoing surgical aneurysm repair (p = 0.004). Conclusion Vasospasmus and a large amount of ventricular blood seem to be a predictor concerning hydrocephalus after non-traumatic SAH. Hence according to our results the presence of these two variables could alert the treating physician in the decision whether an early shunt implantation < 7 days after SAH should be necessary

¿Cómo presentar con éxito tu trabajo en público?, experiencias en tutorización en las enseñanzas técnicas

Quizás la pregunta con la que empieza el título de esta memoria podría tener infinidad de posibles respuestas, muchas de ellas tendrían en común un buen número de posibles soluciones: mejorar nuestra seguridad, nuestra autoconfianza, aprender de cómo otros pronuncian sus discursos, controlando la ansiedad, no temer a equivocarse, reconociéndolo como algo intrínseco al ser humano etcétera, pero a pesar de todo esto sigue siendo una tarea pendiente de nuestro sistema educativo, ya que miles de estudiantes llegan al sistema universitario sin aún desarrollar ciertas habilidades que le permitan afrontar estos miedos. Con esta memoria nos proponemos presentar nuestras experiencias en el desarrollo del Plan de Acción Tutorial (PAT) en la EPS destacando su evolución a lo largo del curso y los cambios experimentados. En el marco del PAT de la Escuela Politécnica Superior (EPS) y en colaboración del Instituto de Ciencias de la Educación (ICE) hemos animado a la participación de nuestros estudiantes a diversos talleres organizados por el ICE y por la Universidad de Alicante en general con el objetivo de ayudarles a fortalecer su seguridad ante una exposición pública de un trabajo como pudiera ser, por ejemplo, el Trabajo Final de Grado (TFG)

La acción tutorial en la EPS, planificación del tiempo, autoconocimiento y toma de decisiones

El carácter voluntario de la inscripción al Plan de Acción Tutorial (PAT) de la Escuela Politécnica Superior (EPS) un año más continúa siendo nuestro sello de identidad. Este carácter, permite una mayor eficacia en el desarrollo de tutorización ya que los agentes implicados en el mismo lo realizan de manera voluntaria. Con esta memoria nos proponemos presentar nuestras experiencias en el desarrollo del PAT en la EPS. La toma de decisiones, proceso mediante el cual se realiza una elección entre las opciones o formas para resolver diferentes situaciones de la vida en diferentes contextos, es un elemento de vital importancia en el desarrollo de la vida académica y futura profesional de nuestros estudiantes. En el marco del PAT de la EPS y en colaboración del Instituto de Ciencias de la Educación (ICE) hemos desarrollado diversos talleres, entre los que destaca un taller vivencial para analizar la importancia en la toma correcta de decisiones

Red de coordinación y seguimiento de la titulación Máster Universitario en Prevención de Riesgos Laborales

El profesorado de la red participó durante el curso 2016/17 en un proyecto de coordinación y seguimiento de la titulación Máster Universitario en Prevención de Riesgos Laborales. En el curso 2016-17 la titulación Máster en Prevención de Riesgos Laborales desarrolla la quinta edición desde su implantación en el curso 2012-13. En el curso 2015-16 la titulación recibió informe favorable de renovación de acreditación emitido por la Agencia para la evaluación, acreditación y prospectiva del sistema de educación superior y de la innovación en la Comunitat Valenciana. En base al mismo la presente red pretende proponer acciones voluntarias para mejorar los criterios que recibieron una calificación de adecuada y contribuir así al plan de acciones de mejora de la titulación para el curso 2016-17. La red ha resultado ser un instrumento útil para coordinación y seguimiento de la titulación Máster Universitario en Prevención de Riesgos Laborales