Feed more on-farm protein. A European strategy in organic agriculture to improve on-farm protein management

The Lifelong Learning Program (Leonardo, action type: mobility) funded our project “European Agricultural Training – renewing skills for experienced organic advisors” (see www.ch-go-est.eu), 2013-2015. The goal of this European partnership project was to facilitate networking and exchange of ideas, experiences, and methods between experienced organic multiplicators (advisors, teachers in agricultural training, researchers etc.). The group had members from several northern and mid-European countries and the focus was on-farm protein management from cultivation to feeding. Field visits to leading organic farms organized by participating organisations, discussion and resulting ideas gave new inputs to the work of the advisors in their own countries and development of approaches to increase sustainability of organic agriculture. Discussion on a common feeding strategy to reduce the need for external input of protein concentrates focussed mainly on ruminant nutrition. These are the conclusions of our projekt concerning a European strategy in organic agriculture to improve on-farm protein management

Linguistic Factors Influencing Speech Audiometric Assessment

In speech audiometric testing, hearing performance is typically measured by calculating the number of correct repetitions of a speech stimulus. We investigate to what extent the repetition accuracy of Dutch speech stimuli presented against a background noise is influenced by nonauditory processes. We show that variation in verbal repetition accuracy is partially explained by morpholexical and syntactic features of the target language. Verbs, prepositions, conjunctions, determiners, and pronouns yield significantly lower correct repetitions than nouns, adjectives, or adverbs. The reduced repetition performance for verbs and function words is probably best explained by the similarities in the perceptual nature of verbal morphology and function words in Dutch. For sentences, an overall negative effect of syntactic complexity on speech repetition accuracy was found. The lowest number of correct repetitions was obtained with passive sentences, reflecting the cognitive cost of processing a noncanonical sentence structure. Taken together, these findings may have important implications for the audiological practice. In combination with hearing loss, linguistic complexity may increase the cognitive demands to process sentences in noise, leading to suboptimal functional hearing in day-to-day listening situations. Using test sentences with varying degrees of syntactic complexity may therefore provide useful information to measure functional hearing benefits

Selected strategies to fight pathogenic bacteria

Natural products and analogues are a source of antibacterial drug discovery. Considering drug resistance levels emerging for antibiotics, identification of bacterial metalloenzymes and the synthesis of selective inhibitors are interesting for antibacterial agent development. Peptide nucleic acids are attractive antisense and antigene agents representing a novel strategy to target pathogens due to their unique mechanism of action. Antisense inhibition and development of antisense peptide nucleic acids is a new approach to antibacterial agents. Due to the increased resistance of biofilms to antibiotics, alternative therapeutic options are necessary. To develop antimicrobial strategies, optimised in vitro and in vivo models are needed. In vivo models to study biofilm-related respiratory infections, device-related infections: ventilator-associated pneumonia, tissue-related infections: chronic infection models based on alginate or agar beads, methods to battle biofilm-related infections are discussed. Drug delivery in case of antibacterials often is a serious issue therefore this review includes overview of drug delivery nanosystems.Peer reviewe

Collaborative Development of a PLE for Language Learning

This paper provides a report on the experimental collaborative and distributed development of a prototypic Widget-based PLE. The development process is described and detailed taking into account the requirements of a language learning scenario. First results are presented, and developer experiences are discussed critically with a focus on the development process as well as problems with current Widget technologies and interoperabilit

Linguistic Factors Influencing Speech Audiometric Assessment

In speech audiometric testing, hearing performance is typically measured by calculating the number of correct repetitions of a speech stimulus. We investigate to what extent the repetition accuracy of Dutch speech stimuli presented against a background noise is influenced by nonauditory processes. We show that variation in verbal repetition accuracy is partially explained by morpholexical and syntactic features of the target language. Verbs, prepositions, conjunctions, determiners, and pronouns yield significantly lower correct repetitions than nouns, adjectives, or adverbs. The reduced repetition performance for verbs and function words is probably best explained by the similarities in the perceptual nature of verbal morphology and function words in Dutch. For sentences, an overall negative effect of syntactic complexity on speech repetition accuracy was found. The lowest number of correct repetitions was obtained with passive sentences, reflecting the cognitive cost of processing a noncanonical sentence structure. Taken together, these findings may have important implications for the audiological practice. In combination with hearing loss, linguistic complexity may increase the cognitive demands to process sentences in noise, leading to suboptimal functional hearing in day-to-day listening situations. Using test sentences with varying degrees of syntactic complexity may therefore provide useful information to measure functional hearing benefits

LiCoS: A new linguistically controlled sentences test to assess functional hearing performance

Purpose: To overcome the potential tension between clinical and ecological validity in speech audiometric assessment by creating a new set of sentence materials with high linguistic validity for the Dutch-speaking area. Methods: A linguistic "fingerprint" of modern spoken Dutch and Flemish served to generate a set of sentences recorded from 1 male and 1 female talker. The sentences were presented to 30 normal-hearing listeners in stationary speech noise at a signal-to-noise ratio (SNR) of -5 dB sound pressure level (SPL). A list design criterion was used to achieve perceptive homogeneity across the test lists, by scrambling lists of sentences of different syntactic types while controlling for linguistic complexity. The original set of test materials was narrowed down to 360 sentences, and list equivalency was evaluated at the audiological and linguistic levels. A psychometric curve was generated with a resolution of 2 dB based on a second group of 60 young normal-hearing native speakers of Dutch and Flemish. Results: Sentence understanding showed an average repetition accuracy of 63.40% (SD 1.01) across the lists at an SNR of -5 dB SPL. No significant differences were found between the lists at the level of the individual listener. At the linguistic level, the sentence lists showed an equal distribution of phonological, morphological, and syntactic features. Conclusion: LiCoS combines the clinical benefit of acoustic control at the list level with the high ecological validity of linguistically representative test items. The new speech audiometric test is particularly appropriate to assess sentence understanding in individuals who would otherwise exhibit near-ceiling performance when tested with linguistically more simplified test stimuli. In combination with pure tone audiometric assessment, LiCoS provides valuable complementary information with respect to the functional hearing of patients