Design and synthesis of aromatic molecules for probing electric-fields at the nanoscale

We propose using halogenated organic dyes as nanoprobes for electric field and show their greatly enhanced Stark coefficients using density functional theory (DFT) calculations. We analyse halogenated variants of three molecules that have been of interest for cryogenic single molecule spectroscopy, perylene, terrylene, and dibenzoterrylene, with the zero-phonon optical transitions at blue, red, and near infrared. Out of all the combinations of halides and binding sites that are calculated, we have found that fluorination of the optimum binding site induces a dipole difference between ground and excited states larger than 0.5 D for all three molecules with the highest value of 0.69 D for fluoroperylene. We also report on synthesis of 3-fluoroterrylene and bulk spectroscopy of this compound in liquid and solid organic environments.Comment: Article presented in Faraday Discussions on September 201

Computing the Mertens and Meissel-Mertens constants for sums over arithmetic progressions

We give explicit numerical values with 100 decimal digits for the Mertens constant involved in the asymptotic formula for $\sum\limits_{\substack{p\leq x p\equiv a \bmod{q}}}1/p$ and, as a by-product, for the Meissel-Mertens constant defined as $\sum_{p\equiv a \bmod{q}} (\log(1-1/p)+1/p)$, for $q \in \{3$, ..., $100\}$ and $(q, a) = 1$.Comment: 12 pages, 6 table

Dangling-bond spin relaxation and magnetic 1/f noise from the amorphous-semiconductor/oxide interface: Theory

We propose a model for magnetic noise based on spin-flips (not electron-trapping) of paramagnetic dangling-bonds at the amorphous-semiconductor/oxide interface. A wide distribution of spin-flip times is derived from the single-phonon cross-relaxation mechanism for a dangling-bond interacting with the tunneling two-level systems of the amorphous interface. The temperature and frequency dependence is sensitive to three energy scales: The dangling-bond spin Zeeman energy delta, as well as the minimum (E_min) and maximum (E_max) values for the energy splittings of the tunneling two-level systems. We compare and fit our model parameters to a recent experiment probing spin coherence of antimony donors implanted in nuclear-spin-free silicon [T. Schenkel {\it et al.}, Appl. Phys. Lett. 88, 112101 (2006)], and conclude that a dangling-bond area density of the order of 10^{14}cm^{-2} is consistent with the data. This enables the prediction of single spin qubit coherence times as a function of the distance from the interface and the dangling-bond area density in a real device structure. We apply our theory to calculations of magnetic flux noise affecting SQUID devices due to their Si/SiO_2 substrate. Our explicit estimates of flux noise in SQUIDs lead to a noise spectral density of the order of 10^{-12}Phi_{0}^{2} {Hz}^{-1} at f=1Hz. This value might explain the origin of flux noise in some SQUID devices. Finally, we consider the suppression of these effects using surface passivation with hydrogen, and the residual nuclear-spin noise resulting from a perfect silicon-hydride surface.Comment: Final published versio

Biodégradation anaérobie de l'acide crotonique par une biomasse bactérienne spécialisée dans la dégradation de l'acide butyrique

La connaissance, actuellement très limitée, du métabolisme des bactéries acétogènes intervenant dans la biodégradation anaérobie de l'acide butyrique et d'un de ses sous-produits, l'acide crotonique, est à l'origine de cette étude.Après avoir mis au point un réacteur anaérobie à biomasse fixée, cette dernière a, dans un premier temps, été adaptée à la biodégradation exclusive du butyrate. La dégradation du crotonate a ensuite été étudiée, selon différents protocoles expérimentaux (pulses de crotonate en alimentation continue avec du butyrate puis alimentation continue avec du crotonate). Des injections de crotonate ont également été effectuées en circuit fermé, avec une biomasse adaptée dans un premier temps à la dégradation d'un mélange d'AGV, le réacteur étant ensuite alimenté avec du propionate puis du butyrate seuls.Contrairement à ce que laissait penser la bibliographie, il a été constaté que les bactéries adaptées à la dégradation exclusive du butyrate sons très rapidement à même de dégrader le crotonate.Les résultats obtenus permettent d'approcher les spécificités bactériennes, la voie catabolique suivie par le crotonate, son mode de régulation enzymatique et les équilibres qui la gouvernent. C'est ainsi qu'il est possible de proposer un modèle explicatif relativement simple du mécanisme de biodégradation du crotonate.Volatile Fatty Acids (VFAs) are intermediate metabolites formed in the anaerobic biodegradation of organic matter. They are commonly found in sewage, municipal sanitary landfill leachate and effluents from agricultural and food-processing industries. A good knowledge of the microorganisms involved in VFA biodegradation is necessary to operate satisfactory biotreatment of those effluents.The objective of the present study is to better understand the metabolism of the anaerobic bacteria responsible for the degradation of butyric acid and one of its metabolites (crotonic acid), which is still poorly known.Syntrophomonaswolfei is one of the few butyrate-degrading acetogenic bacteria that bas been documented. First studios have shown that this microorganism is not capable of degrading crotonic acid (MCINERNEY et al., 1979, 1981). This is surprising since crotonyl-Coenzyme A, in its activated form, is an intermediate metabolite of n-butyrate ß-oxidation, which is the most common mechanism of butyrate biodegradation. In addition, ß-oxidatlon of crotonate is thermodynamically possible, even under standard conditions.These observations are al the origin of the present study, which investigates the anaerobic biodegradation of crotonate. Other Investigators have followed a similar approach and isolated S. wolfei in pure culture on crotonate.The degradation of crotonate was studied in a bench-scale up-flow anaerobic filter of twenty liters, operated in the dark, at 35 °C.A first set of experiments was carried out with a biomass exclusively adapted to the biodegradation of butyrate. Heat-expansed vermiculite was used as a packing medium. Various experimental protocols were successive followed. First, pulses of crotonate were injected into the reactor under conditions of continuous feeding with butyrate, and then, the reactor was continuously fed with crotonate. The objective was to determine whether a bacterial population exclusively adapted to butyrate biodegradation would be capable of degrading crotonate.It was found that crotonate was actually biodegraded in the reactor. Woth the first protocol, when pulses of crotonate were injected into the reactor, crotonate was totally removed in 55 hours (fig. 3). Butyrate and acetate concentrations increased as crotonate was degraded, but no significant increase in biogas production was observed. On the other hand, under the same conditions, it was found that iso-butyrate was not degraded, which is consistent with other published data (MCINERNEY et al., 1979, 1981 ; STIEB and SCHINK, 1985,1989).With the second protocol (continuous feeding with crotonate at 5.2 gg/l), crotonate was totally biodegraded in 48 hours after a 24 hours lag period. This biodegradation resulted in the accumulation of acetate and, in a lower extend, butyrate (fig.4).Following this stage, the reactor was fed with a higher crotonate concentration (12 g/l), and it was observed that crotonate was totally degraded in 20 hours, without any lag period (fig. 5).These results showed that butyrate-degrading bacteria were capable of degrading crotonate effectively after a short period of adaptation.Further experiments were conducted with a biomass previously adapted to the degradation of a mixture of VFAs (acetate, propionate, iso-butyrate, butyrate and caproate). Berl saddles were used as a support for bacterial growth. The reactor was operated in a recirculated batch mode and spiked with crotonate. Finally, the reactor was successively fed for four weeks with propionate and for two weeks with butyrate, before being spiked with crotonate.In all these experiments, crotonate biodegradation was observed, but, in contrast to the results obtained with the “vermiculite reactor”, no butyrate accumulation occured (fig.6).These results show that a bacterial population adapted to the degradation of a mixture of VFAs or to the degradation of individual VFAs such as propionate and n-butyrate, is capable of degrading crotonate.Based on the present study and on literature data, the following mechanism can be proposed for the biodegradation of crotonate (fig.7). The first stage is the activation of crotonate into crotonyl-Coenzyme A by an acetyl-CoA/crotonyl-CoA transferase, as recently isolated from S. wolfei (BEATY and MCINERNEY, 1987). When present at low concentrations, crotonate is probably directly degraded into acetate, as shown by the results obtained with the “selles de Berl reactor”, in which no intermediate metabolite has been detected. At higher concentrations, enzymatic sites may be saturated and an equilibrium be established with butyrate, which is then released into the medium. This has been shown by the accumulation of butyrate under conditions of continuous feeding with crotonate. In addition, another intermediate metabolite has been formed, which has not been identified in the present study. This product is most probably poly-ß-hydroxy-butyrate, which has been found in S.wolfei (MCINERNEY et al, 1979) although if is not very common in chemiotrophic bacteria

Impeded Growth of Magnetic Flux Bubbles in the Intermediate State Pattern of Type I Superconductors

Normal state bubble patterns in Type I superconducting Indium and Lead slabs are studied by the high resolution magneto-optical imaging technique. The size of bubbles is found to be almost independent of the long-range interaction between the normal state domains. Under bubble diameter and slab thickness proper scaling, the results gather onto a single master curve. On this basis, in the framework of the "current-loop" model [R.E. Goldstein, D.P. Jackson and A.T. Dorsey, Phys. Rev. Lett. 76, 3818 (1996)], we calculate the equilibrium diameter of an isolated bubble resulting from the competition between the Biot-and-Savart interaction of the Meissner current encircling the bubble and the superconductor-normal interface energy. A good quantitative agreement with the master curve is found over two decades of the magnetic Bond number. The isolation of each bubble in the superconducting matrix and the existence of a positive interface energy are shown to preclude any continuous size variation of the bubbles after their formation, contrary to the prediction of mean-field models.Comment: \'{e}quipe Nanostructures Quantique

The expansion of 300 CTG repeats in myotonic dystrophy transgenic mice does not induce sensory or motor neuropathy

Summary: Although many studies have been carried out to verify the involvement of the peripheral nervous system (PNS) in dystrophia myotonica (DM1) patients, the results remain controversial. The generation of DM1 transgenic mice displaying the human DM1 phenotype provides a useful tool to investigate the type and incidence of structural abnormalities in the PNS. In the present study, the morphological and morphometric analysis of semi-thin sections of sciatic and sural nerves, lumbar dorsal root ganglia (DRG) and lumbar spinal cords revealed that in DM1 transgenic mice carrying 300 CTG repeats, there is no change in the number and diameter of myelinated axons compared to wild type. Only a non-significant reduction in the percentage of thin myelinated axons was detected in electron micrographs of ultra-thin sciatic nerve sections. Analysis of the number of neurons did not reveal a loss in number of either sensory neurons in the lumbar DRG or motor neurons in the lumbar spinal cord in these DM1 mice. Furthermore, in hind limb muscle sections, stained with a neurofilament antibody and α-bungarotoxin, the intramuscular axon arborization appeared normal in DM1 mice and undistinguishable from that in wild-type mice. Moreover, in DM1 mice, there was no irregularity in the structure or an increase in the endplate area. Also statistical analysis did not show an increase in endplate density or in the concentration of acetylcholine receptors. Altogether, these results suggest that 300 CTG repeats are not sufficient to induce axonopathy, demyelination or neuronopathies in this transgenic mouse mode

Nucleation and Collapse of the Superconducting Phase in Type-I Superconducting Films

The phase transition between the intermediate and normal states in type-I superconducting films is investigated using magneto-optical imaging. Magnetic hysteresis with different transition fields for collapse and nucleation of superconducting domains is found. This is accompanied by topological hysteresis characterized by the collapse of circular domains and the appearance of lamellar domains. Magnetic hysteresis is shown to arise from supercooled and superheated states. Domain-shape instability resulting from long-range magnetic interaction accounts well for topological hysteresis. Connection with similar effects in systems with long-range magnetic interactions is emphasized

Scale invariant correlations and the distribution of prime numbers

Negative correlations in the distribution of prime numbers are found to display a scale invariance. This occurs in conjunction with a nonstationary behavior. We compare the prime number series to a type of fractional Brownian motion which incorporates both the scale invariance and the nonstationary behavior. Interesting discrepancies remain. The scale invariance also appears to imply the Riemann hypothesis and we study the use of the former as a test of the latter.Comment: 13 pages, 8 figures, version to appear in J. Phys.

RAPIC project: toward a new generation of inexpensive heat exchanger-reactors for process intensification

Process intensification (PI) in chemical production is a major concern of chemical manufacturers. This alternative technology involves transposing syntheses into continuous plug flow reactors with process intensification, leading to a multifunctional heat exchanger-reactor. In this context, the RAPIC R&D project aims to develop an innovative low-cost component (in the 10 kg/hour range). This project deals with the design from the local to the global scale and with testing, from elementary mock-ups to pilot scale. The present paper gives a detailed description of this research project and presents the main results on specification and definition of the reaction channel and the first simple mock-ups