1,317 research outputs found
A closed loop cryogenic environment pressure regulating system
Nonlinear closed loop control system to regulate the pressure in a cryogenic environment is described. System employs four position contactor with two control bands to react to the signals. Diagrams of element transfer function and required equipment are included
Comment on 'Fatal, incidental, idiopathic pulmonary fibrosis in a patient receiving long-term low-dose methotrexate for psoriasis':reply from author
Reply to Gohar on ‘Lungs, methotrexate and psoriasis’, a comment on ‘Fatal, incidental, idiopathic pulmonary fibrosis in a patient receiving long-term low-dose methotrexate for psoriasis’
Fatal, incidental, idiopathic pulmonary fibrosis in a patient receiving long-term low-dose methotrexate for psoriasis
Inference under unequal probability sampling with the Bayesian exponentially tilted empirical likelihood.
Fully Bayesian inference in the presence of unequal probability sampling requires stronger structural assumptions on the data-generating distribution than frequentist semiparametric methods, but offers the potential for improved small-sample inference and convenient evidence synthesis. We demonstrate that the Bayesian exponentially tilted empirical likelihood can be used to combine the practical benefits of Bayesian inference with the robustness and attractive large-sample properties of frequentist approaches. Estimators defined as the solutions to unbiased estimating equations can be used to define a semiparametric model through the set of corresponding moment constraints. We prove Bernstein-von Mises theorems which show that the posterior constructed from the resulting exponentially tilted empirical likelihood becomes approximately normal, centred at the chosen estimator with matching asymptotic variance; thus, the posterior has properties analogous to those of the estimator, such as double robustness, and the frequentist coverage of any credible set will be approximately equal to its credibility. The proposed method can be used to obtain modified versions of existing estimators with improved properties, such as guarantees that the estimator lies within the parameter space. Unlike existing Bayesian proposals, our method does not prescribe a particular choice of prior or require posterior variance correction, and simulations suggest that it provides superior performance in terms of frequentist criteria.MR
PCV10: DEFINING OUTCOMES IN STUDIES OF BLEEDING MORBIDITY ASSOCIATED WITH ANTICOAGULATION THERAPY
MultiBUGS: A Parallel Implementation of the BUGS Modeling Framework for Faster Bayesian Inference
MultiBUGS is a new version of the general-purpose Bayesian modeling software BUGS
that implements a generic algorithm for parallelizing Markov chain Monte Carlo (MCMC)
algorithms to speed up posterior inference of Bayesian models. The algorithm parallelizes evaluation of the product-form likelihoods formed when a parameter has many
children in the directed acyclic graph (DAG) representation; and parallelizes sampling
of conditionally-independent sets of parameters. A heuristic algorithm is used to decide
which approach to use for each parameter and to apportion computation across computational cores. This enables MultiBUGS to automatically parallelize the broad range of
statistical models that can be fitted using BUGS-language software, making the dramatic
speed-ups of modern multi-core computing accessible to applied statisticians, without
requiring any experience of parallel programming. We demonstrate the use of MultiBUGS on simulated data designed to mimic a hierarchical e-health linked-data study
of methadone prescriptions including 425,112 observations and 20,426 random effects.
Posterior inference for the e-health model takes several hours in existing software, but
MultiBUGS can perform inference in only 28 minutes using 48 computational core
The global transformation of geomorphology
This chapter reviews the various developments in geomorphology in terms of institutions, journals, textbooks, research stations, etc. Among the institutions discussed are the Binghamton Geomorphology Symposium, the Geological Society of America Quaternary Geology and Geomorphology Division, the Association of American Geographers Geomorphology Specialty Group, the British Geomorphological Research Group, the IGU Commission on Measurements, Theory and Application in Geomorphology (COMTAG), the International Association of Geomorphologists, the European Geosciences Union (EGU), the American Geophysical Union (AGU), the International Quaternary Association, and the International Conference on Aeolian Research. Many countries established their own national bodies. A number of new journals appeared, including Catena, Earth Surface Processes and Landforms, Géomorphologie, and Geomorphology. In addition, during the closing decades of the twentieth century there was a proliferation of textbooks in geomorphology. One development was that geomorphological research was promoted by the establishment of research stations. These permitted long-term monitoring and provided bases for sustained investigations. The study of fluvial processes was much encouraged in the United States at USDA Forest Service research basins (known as ‘watersheds’ in the USA) such as the Hubbard Brook Experimental Forest (New Hampshire), Coweeta Hydrologic Laboratory (North Carolina) and the H.J. Andrews Experimental Forest (Oregon). The Royal Geographical Society (with the Institute of British Geographers) organized ambitious research projects in collaboration with host nations. Various US government departments supported much geomorphological research in various parts of the world. Some European countries fostered overseas geomorphological research and created missions. Notable was the work of ORSTOM (Office de la Recherche Scientifique et Technique Outre-mer) in former francophone colonies. In the post-war years, and as independence approached and then occurred, new universities were established in Africa. These employed expatriate geomorphologists and also trained up a new generation of indigenous scholars. The decades since the 1960s have been a period of space exploration and the development of remote sensing. This has had important implications for geomorphology. The period also saw the onset of the digital age and the beginning of the World Wide Web's influence on teaching and research. Applied research became increasingly important. A major cause for international and cross-disciplinary co-operation during the period was the emergence of geoarchaeology. Finally, since the 1950s, an increasing number of women have made important contributions to the discipline
Faecal haemoglobin can define risk of colorectal neoplasia at surveillance colonoscopy in patients at increased risk of colorectal cancer.
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