Early mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study

Background Early mobilisation (EM) is an intervention that may improve the outcome of critically ill patients. There is limited data on EM in COVID-19 patients and its use during the first pandemic wave. Methods This is a pre-planned subanalysis of the ESICM UNITE-COVID, an international multicenter observational study involving critically ill COVID-19 patients in the ICU between February 15th and May 15th, 2020. We analysed variables associated with the initiation of EM (within 72 h of ICU admission) and explored the impact of EM on mortality, ICU and hospital length of stay, as well as discharge location. Statistical analyses were done using (generalised) linear mixed-effect models and ANOVAs. Results Mobilisation data from 4190 patients from 280 ICUs in 45 countries were analysed. 1114 (26.6%) of these patients received mobilisation within 72 h after ICU admission; 3076 (73.4%) did not. In our analysis of factors associated with EM, mechanical ventilation at admission (OR 0.29; 95% CI 0.25, 0.35; p = 0.001), higher age (OR 0.99; 95% CI 0.98, 1.00; p ≤ 0.001), pre-existing asthma (OR 0.84; 95% CI 0.73, 0.98; p = 0.028), and pre-existing kidney disease (OR 0.84; 95% CI 0.71, 0.99; p = 0.036) were negatively associated with the initiation of EM. EM was associated with a higher chance of being discharged home (OR 1.31; 95% CI 1.08, 1.58; p = 0.007) but was not associated with length of stay in ICU (adj. difference 0.91 days; 95% CI − 0.47, 1.37, p = 0.34) and hospital (adj. difference 1.4 days; 95% CI − 0.62, 2.35, p = 0.24) or mortality (OR 0.88; 95% CI 0.7, 1.09, p = 0.24) when adjusted for covariates. Conclusions Our findings demonstrate that a quarter of COVID-19 patients received EM. There was no association found between EM in COVID-19 patients' ICU and hospital length of stay or mortality. However, EM in COVID-19 patients was associated with increased odds of being discharged home rather than to a care facility. Trial registration ClinicalTrials.gov: NCT04836065 (retrospectively registered April 8th 2021)

Percepción materna del estado nutricional de sus hijos que acuden a un consultorio pediátrico, Asunción, 2018

Introducción: La percepción de la madre acerca del estado nutricional de su hijo es clave para el éxito o fracaso de las medidas preventivas o terapéuticas a implementar en relación a la obesidad. El objetivo de este trabajo fue evaluar la concordancia entre la percepción de las madres acerca del estado nutricional de sus hijos y su estado nutricional real. Materiales y Métodos: Estudio observacional, descriptivo con componente analítico, trasversal. La percepción materna del estado nutricional del hijo fue comparada con el índice de masa corporal real. Los datos fueron expresados en porcentajes. La concordancia se determinó a través del coeficiente Kappa de Cohen (p£0,05).  Para evaluar los factores asociados con la falla de la madre en percibir correctamente el estado nutricional de su hijo se realizó el análisis de regresión logística bivariada y mutivariado con los factores significativos. Resultados: Fueron evaluados 636 pacientes, 54% masculinos, con edad media de 10 años. Se encontraban con peso adecuado 57%, bajo peso 9%, sobrepeso 22% y obesidad 11%.  El 59,9% de las madres clasificaron correctamente el estado nutricional de su hijo, kappa 0,09 (p=0,0003).  Los factores asociados significativamente con la falla de la madre en percibir correctamente el estado nutricional de su hijo fueron: el sexo masculino (OR 1,54), edad entre 4 a 9 años (OR 1,92), edad entre 9 a 14 años (OR 1,23) e  Indice de Masa Corporal – Z score para edad y sexo (OR 2,04). El análisis multivariado mostró valores similares (p£0,001). Conclusión: Aproximadamente el 60% de las madres clasifican el estado nutricional de sus hijos de manera correcta. Sin embargo, los niños con sobrepeso y obesidad son reconocidos por sus madres como tales sólo en un 31% de los casos. Se considera estos hallazgos como de gran importancia para el éxito de los programas de intervención en obesidad.   Correspondencia: Leticia Ramírez Pastore; Correo: [email protected] Conflicto de interés: Los autores declaran no poseer conflicto de interés Recibido: 13/11/2018; Aceptado: 12/12/201

Nivel de actividad física y estado nutricional en una población pediátrica de un consultorio ambulatorio Asunción.

Introducción: El descenso en el nivel de actividad física en los niños y adolescentes se asocia con mayores niveles de sobrepeso, obesidad y empeoramiento de la salud cardiovascular. Objetivo: Analizar los hábitos de práctica física, parámetros antropométricos y tiempo de pantalla (televisión, teléfonos móviles, tabletas) en una población escolar que acude a consulta pediátrica ambulatoria en Asunción durante el 2018. Materiales y Métodos: Estudio observacional, descriptivo con componente analítico, trasversal. El nivel de actividad física se valoró a través del cuestionario Physical Activity Questionnaire for Children (PAQ-C), con puntajes de 1 a 5, siendo 5 la máxima actividad física. Se incorporó una pregunta sobre el número de horas al día frente a las pantallas. Las variables antropométricas evaluadas fueron el índice de masa corporal (IMC), Z-score del IMC, pliegue tricipital y circunferencia abdominal. Las variables se presentaron como media y desviación estándar. Los datos se analizaron las pruebas T-Student y Chi cuadrado. El nivel de significancia establecido fue <0,05. Resultados: Fueron evaluados 636 escolares, 54% de sexo masculino, con edad media de 10 años, un 11,3 % presentó obesidad y un 22,2 % sobrepeso. La actividad física medida por PAQ-C obtuvo de media 2,93±0,65 puntos. El promedio de tiempo de pantalla fue de 3,53±2,33 horas. En función del sexo no se encontraron diferencias significativas para la edad, tampoco para los parámetros antropométricos, ni horas de pantalla. La división en terciles de los valores de actividad física mostró diferencias significativas con el IMC, Z-score del IMC y pliegue tricipital, no así con la circunferencia abdominal (p=0,089). Por otro lado, los niños menos activos son los que manifestaron pasar más tiempo frente a las pantallas (p=0,006). Conclusión: Los menores niveles de actividad física son reportados por aquellos niños que pasan más tiempo frente a las pantallas, que presentan un mayor índice de masa corporal y Z-score IMC, así como un mayor pliegue tricipital. Conflicto de interés: Los autores declaran no poseer conflicto de interés Recibido: 15/11/2019 Aceptado: 6/02/202

Spontaneous clearance of Chlamydia trachomatis accounting for bacterial viability in vaginally or rectally infected women (FemCure)

Objectives Spontaneous clearance of Chlamydia trachomatis (CT) infections can occur between diagnosis and treatment. We followed CT patients to assess clearance using a conventional definition (no total CT-DNA, assessed by routine quantitative PCR methods) and a definition accounting for viability, assessed by viability PCR testing. Methods Three outpatient STI clinics included CT-diagnosed women (The Netherlands, 2016-2017, FemCure study); participants had vaginal CT (vCT) and rectal CT (rCT) (group A: n=155), vCT and were rectally untested (group B: n=351), single vCT (group C: n=25) or single rCT (group D: n=29). Follow-up (median interval 9 days) vaginal and rectal samples underwent quantitative PCR testing (detecting total CT-DNA). When PCR positive, samples underwent V-PCR testing to detect 'viable CT' (CT-DNA from intact CT organisms; V-PCR positive). 'Clearance' was the proportion PCR-negative patients and 'clearance of viable CT' was the proportion of patients testing PCR negative or PCR positive but V-PCR negative. We used multivariable logistic regression analyses to assess diagnosis group (A-D), age, days since initial CT test (diagnosis) and study site (STI clinic) in relation to clearance and clearance of viable CT. Results Clearance and clearance of viable CT at both anatomic sites were for (A) 0.6% and 3.9%; (B) 5.4% and 9.4%; (C) 32.0% and 52.0% and (D) 27.6% and 41.4%, respectively. In multivariate analyses, women with single infections (groups C and D) had higher likelihood of clearance than women concurrently infected with vCT and rCT (p Of rectally untested women (group B), 76.9% had total CT-DNA and 46.7% had viable CT (V-PCR positive) at the rectal site. Conclusions Of untreated female vCT patients who had CT also at the rectal site, or who were rectally untested, only a small proportion cleared CT (in fact many had viable CT) at their follow-up visit (median 9 days). Among single site infected women clearance was much higher

Evidence of a large, international network of HCV transmission in HIV-positive men who have sex with men

Since 2000, there has been a marked rise in acute hepatitis C virus (HCV) in human immunodeficiency virus (HIV)-positive men who have sex with men (MSM). We conducted an international phylogenetic study to investigate the existence of an HCV transmission network among MSM. HIV-positive MSM diagnosed with recent HCV (n = 226) in England (107), The Netherlands (58), France (12), Germany (25), and Australia (24) between 2000 and 2006 were enrolled into a molecular phylogenetic study. Using real-time polymerase chain reaction (PCR), the NS5B region of the HCV genome (436 base pair) was amplified, sequenced, and compared with unrelated NS5B sequences. NS5B sequences were obtained from 200 (89%) cases. Circulating HCV genotypes were 1a (59%), 4d (23%), 3a (11%), 1b (5%), and 2b/c (3%). Phylogenetic analysis revealed 156 (78%) sequences that formed 11 clusters (bootstrap value > 70%) containing between 4 and 37 individual sequences. Country mixing was associated with larger cluster size (17 vs 4.5 sequences; P = .03). "Molecular clock" analysis indicated that the majority (85%) of transmissions occurred since 1996. Phylogenetic analysis revealed a large international network of HCV transmission among HIV-positive MSM. The rapid spread of HCV among neighboring countries is supported by the large proportion (74%) of European MSM infected with an HCV strain co-circulating in multiple European countries, the low evolutionary distances among HCV isolates from different countries, and the trend toward increased country mixing with increasing cluster size. Temporally, this epidemic coincides with the introduction of highly active antiretroviral therapy and associated increases in sexual risk behaviors. International collaborative public health efforts are needed to mitigate HCV transmission among this populatio

Participation, retention, and associated factors of women in a prospective multicenter study on <i>Chlamydia trachomatis</i> infections (FemCure)

Prospective studies are key study designs when attempting to unravel health mechanisms that are widely applicable. Understanding the internal validity of a prospective study is essential to judge a study's quality. Moreover, insights in possible sampling bias and the external validity of a prospective study are useful to judge the applicability of a study's findings. We evaluated participation, retention, and associated factors of women in a multicenter prospective cohort (FemCure) to understand the study's validity.Chlamydia trachomatis (CT) infected adult women, negative for HIV, syphilis, and Neisseria gonorrhoeae were eligible to be preselected and included at three sexually transmitted infection (STI) clinics in the Netherlands (2016-2017). The planned follow-up for participants was 3 months, with two weekly rectal and vaginal CT self-sampling and online questionnaires administered at home and at the clinic. We calculated the proportions of preselected, included, and retained (completed follow-up) women. Associations with non-preselection, noninclusion, and non-retention (called attrition) were assessed (logistic and Cox regression).Among the 4,916 women, 1,763 (35.9%) were preselected, of whom 560 (31.8%) were included. The study population had diverse baseline characteristics: study site, migration background, high education, and no STI history were associated with non-preselection and noninclusion. Retention was 76.3% (n = 427). Attrition was 10.71/100 person/month (95% confidence interval 9.97, 12.69) and was associated with young age and low education. In an outpatient clinical setting, it proved feasible to include and retain women in an intensive prospective cohort. External validity was limited as the study population was not representative (sampling bias), but this did not affect the internal validity. Selective attrition, however (potential selection bias), should be accounted for when interpreting the study results

Co-infection and ICU-acquired infection in COIVD-19 ICU patients: a secondary analysis of the UNITE-COVID data set

Background: The COVID-19 pandemic presented major challenges for critical care facilities worldwide. Infections which develop alongside or subsequent to viral pneumonitis are a challenge under sporadic and pandemic conditions; however, data have suggested that patterns of these differ between COVID-19 and other viral pneumonitides. This secondary analysis aimed to explore patterns of co-infection and intensive care unit-acquired infections (ICU-AI) and the relationship to use of corticosteroids in a large, international cohort of critically ill COVID-19 patients.Methods: This is a multicenter, international, observational study, including adult patients with PCR-confirmed COVID-19 diagnosis admitted to ICUs at the peak of wave one of COVID-19 (February 15th to May 15th, 2020). Data collected included investigator-assessed co-infection at ICU admission, infection acquired in ICU, infection with multi-drug resistant organisms (MDRO) and antibiotic use. Frequencies were compared by Pearson's Chi-squared and continuous variables by Mann-Whitney U test. Propensity score matching for variables associated with ICU-acquired infection was undertaken using R library MatchIT using the "full" matching method.Results: Data were available from 4994 patients. Bacterial co-infection at admission was detected in 716 patients (14%), whilst 85% of patients received antibiotics at that stage. ICU-AI developed in 2715 (54%). The most common ICU-AI was bacterial pneumonia (44% of infections), whilst 9% of patients developed fungal pneumonia; 25% of infections involved MDRO. Patients developing infections in ICU had greater antimicrobial exposure than those without such infections. Incident density (ICU-AI per 1000 ICU days) was in considerable excess of reports from pre-pandemic surveillance. Corticosteroid use was heterogenous between ICUs. In univariate analysis, 58% of patients receiving corticosteroids and 43% of those not receiving steroids developed ICU-AI. Adjusting for potential confounders in the propensity-matched cohort, 71% of patients receiving corticosteroids developed ICU-AI vs 52% of those not receiving corticosteroids. Duration of corticosteroid therapy was also associated with development of ICU-AI and infection with an MDRO.Conclusions: In patients with severe COVID-19 in the first wave, co-infection at admission to ICU was relatively rare but antibiotic use was in substantial excess to that indication. ICU-AI were common and were significantly associated with use of corticosteroids