2,110 research outputs found
INTEGRAL high energy behaviour of 4U 1812-12
The low mass X-ray binary system 4U 1812-12 was monitored with the INTEGRAL
observatory in the period 2003-2004 and with BeppoSAX on April 20, 2000. We
report here on the spectral and temporal analysis of both persistent and burst
emission. The full data set confirms the persistent nature of this burster, and
reveals the presence of emission up to 200 keV. The persistent spectrum is well
described by a comptonization (CompTT) model plus a soft blackbody component.
The source was observed in a hard spectral state with a 1-200 keV luminosity of
2*10^(36) ergs/s and L/LEdd~1% and no meaningful flux variation has been
revealed, as also confirmed by a 2004 RXTE observation. We have also detected 4
bursts showing double peaked profiles and blackbody spectra with temperatures
ranging from 1.9 to 3.1 keV.Comment: 6 pages, 4 figures. Accepted for publication by A&
The X-ray spectrum of the bursting atoll source 4U~1728-34 observed with INTEGRAL
We present for the first time a study of the 3-200 keV broad band spectra of
the bursting atoll source 4U 1728-34 (GX 354-0) along its hardness intensity
diagram. The analysis was done using the INTEGRAL public and Galactic Center
deep exposure data ranging from February 2003 to October 2004. The spectra are
well described by a thermal Comptonization model with an electron temperature
from 35 keV to 3 keV and Thomson optical depth, tau_T, from 0.5 to 5 in a slab
geometry. The source undergoes a transition from an intermediate/hard to a soft
state where the source luminosity increases from 2 to 12% of Eddington. We have
also detected 36 type I X-ray bursts two of which show photospheric radius
expansion. The energetic bursts with photospheric radius expansion occurred at
an inferred low mass accretion rate per unit area of \dot m ~ 1.7x10E3 g/cm2/s,
while the others at a higher one between 2.4x10E3 - 9.4x10E3 g/cm2/s. For
4U1728-34 the bursts' total fluence, and the bursts' peak flux are
anti-correlated with the mass accretion rate. The type I X-ray bursts involve
pure helium burning either during the hard state, or during the soft state of
the source.Comment: 11 pages, 7 figures, and 2 tables. Accepted for publication in A&
MicroRNA networks surrounding APP and amyloid-β metabolism - implications for Alzheimer's disease
MicroRNAs (miRNAs) are small non-coding RNA regulators of protein synthesis that function as "fine-tuning" tools of gene expression in development and tissue homeostasis. Their profiles are significantly altered in neurodegenerative diseases such as Alzheimer's disease (AD) that is characterized by both amyloid-β (Aβ) and tau deposition in brain. A key challenge remains in determining how changes in miRNA profiles translate into biological function in a physiological and pathological context. The key lies in identifying specific target genes for deregulated miRNAs and understanding which pathogenic factors trigger their deregulation. Here we review the literature about the intricate network of miRNAs surrounding the regulation of the amyloid precursor protein (APP) from which Aβ is derived by proteolytic cleavage. Normal brain function is highly sensitive to any changes in APP metabolism and miRNAs function at several steps to ensure that the correct APP end product is produced and in the right form and abundance. Disruptions in this miRNA regulatory network may therefore alter Aβ production, which in turn can affect miRNA expression
Discovery of a Transition to Global Spin-up in EXO 2030+375
EXO 2030+375, a 42-second transient X-ray pulsar with a Be star companion,
has been observed to undergo an outburst at nearly every periastron passage for
the last 13.5 years. From 1994 through 2002, the global trend in the pulsar
spin frequency was spin-down. Using RXTE data from 2003 September, we have
observed a transition to global spin-up in EXO 2030+375. Although the spin
frequency observations are sparse, the relative spin-up between 2002 June and
2003 September observations, along with an overall brightening of the outbursts
since mid 2002 observed with the RXTE ASM, accompanied by an increase in
density of the Be disk, indicated by infrared magnitudes, suggest that the
pattern observed with BATSE of a roughly constant spin frequency, followed by
spin-up, followed by spin-down is repeating. If so this pattern has
approximately an 11 year period, similar to the 15 +/- 3 year period derived by
Wilson et al. (2002) for the precession period of a one-armed oscillation in
the Be disk. If this pattern is indeed repeating, we predict a transition from
spin-up to spin-down in 2005.Comment: Accepted for publication in ApJ Letters, 4 pages, 5 figures, using
emulateapj.cl
Short GRBs at the dawn of the gravitational wave era
We derive the luminosity function and redshift distribution of short Gamma
Ray Bursts (SGRBs) using (i) all the available observer-frame constraints (i.e.
peak flux, fluence, peak energy and duration distributions) of the large
population of Fermi SGRBs and (ii) the rest-frame properties of a complete
sample of Swift SGRBs. We show that a steep with a>2.0
is excluded if the full set of constraints is considered. We implement a Monte
Carlo Markov Chain method to derive the and functions
assuming intrinsic Ep-Liso and Ep-Eiso correlations or independent
distributions of intrinsic peak energy, luminosity and duration. To make our
results independent from assumptions on the progenitor (NS-NS binary mergers or
other channels) and from uncertainties on the star formation history, we assume
a parametric form for the redshift distribution of SGRBs. We find that a
relatively flat luminosity function with slope ~0.5 below a characteristic
break luminosity ~3 erg/s and a redshift distribution of SGRBs
peaking at z~1.5-2 satisfy all our constraints. These results hold also if no
Ep-Liso and Ep-Eiso correlations are assumed. We estimate that, within ~200 Mpc
(i.e. the design aLIGO range for the detection of GW produced by NS-NS merger
events), 0.007-0.03 SGRBs yr should be detectable as gamma-ray events.
Assuming current estimates of NS-NS merger rates and that all NS-NS mergers
lead to a SGRB event, we derive a conservative estimate of the average opening
angle of SGRBs: ~3-6 deg. Our luminosity function implies an
average luminosity L~1.5 erg/s, nearly two orders of magnitude
higher than previous findings, which greatly enhances the chance of observing
SGRB "orphan" afterglows. Efforts should go in the direction of finding and
identifying such orphan afterglows as counterparts of GW events.Comment: 13 pages, 5 figures, 2 tables. Accepted for publication in Astronomy
& Astrophysics. Figure 5 and angle ranges corrected in revised versio
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