1,652 research outputs found
The Integral Burst Alert System (IBAS)
We describe the INTEGRAL Burst Alert System (IBAS): the automatic software
for the rapid distribution of the coordinates of the Gamma-Ray Bursts detected
by INTEGRAL. IBAS is implemented as a ground based system, working on the
near-real time telemetry stream. During the first six months of operations, six
GRB have been detected in the field of view of the INTEGRAL instruments and
localized by IBAS. Positions with an accuracy of a few arcminutes are currently
distributed by IBAS to the community for follow-up observations within a few
tens of seconds of the event.Comment: 7 pages, latex, 5 figures, Accepted for publication on A&A Special
Issue on First Science with INTEGRA
S-antigen and rod-opsin immunoreactions in midline brain neoplasms of transgenic mice: Similarities to pineal cell tumors and certain medulloblastomas in man.
Transgenic mice expressing the large T-antigen of the simian virus 40 (SV 40) under the control of 1) the enhancer of Moloney murine sarcoma virus (MSV) and 2) the SV 40 promoter develop undifferentiated neuroectodermal tumors located in the midline of the dorsal brain surface, abnormalities in lens fiber differentiation and retinal dysplasia. In this study the brain neoplasms of six adult animals and the brain of one 11-day old mouse were examined by conventional histology and immunocytochemical demonstration of S-antigen, rod-opsin, neuron-specific enolase, neurofilaments (160 and 200 kDa) and glial fibrillary acidic protein. According to histologic criteria the neoplasms were characterized as "primitive" neuroectodermal tumors composed mainly of small cells with scanty and ill-defined cytoplasm. Neoplastic cells displaying immunoreactive S-antigen were found in five brain tumors; three of these tumors also contained a limited number of rod-opsin immunoreactive neoplastic cells. Some tumor cells had neurite-like processes containing immunoreactive neurofilament (200 kDa). No pathologic lesions were found in the brain of the 11-day old animal. Tumors in transgenic mice may resemble pineal cell tumors and a special subtype of medulloblastoma in man. These neoplasms contain S-antigen immunoreactive and also rod-opsin immunoreactive tumors cells in certain cases. The findings suggest that transgenic mice expressing the large T-antigen of SV 40 may become a valuable animal model for analysing the origin, histogenesis and development of primitive neuroectodermal tumors with photoreceptor-like features (pineal cell tumors and certain medulloblastomas)
The Unique Frequency Spectrum of the Blazhko RRc Star LS Her
The Blazhko effect in RR Lyrae stars is still poorly understood
theoretically. Stars with multiple Blazhko periods or in which the Blazhko
effect itself varies are particularly challenging. This study investigates the
Blazhko effect in the RRc star LS Her. Detailed VRI CCD photometry has been
performed on 63 nights during six months. LS Her is confirmed to have a Blazhko
period of 12.75+/-0.02 days. However, where normally the side frequencies of
the Blazhko triplet are expected, an equidistant group of three frequencies is
found on both sides of the main pulsation frequency. As a consequence the
period and amplitude of the Blazhko effect itself vary in a cycle of 109+/-4
days. LS Her is a unique object turning out to be very important in the
verification of the theories for the Blazhko effect.Comment: Accepted for publication in MNRA
IGR J08408--4503: a new recurrent Supergiant Fast X-ray Transient
The supergiant fast X-ray transient IGR J08408-4503 was discovered by
INTEGRAL on May 15, 2006, during a bright flare. The source shows sporadic
recurrent short bright flares, reaching a peak luminosity of 10^36 erg s^-1
within less than one hour. The companion star is HD 74194, an Ob5Ib(f)
supergiant star located at 3 kpc in the Vela region. We report the light curves
and broad-band spectra (0.1-200 keV) of all the three flares of IGR J08408-4503
detected up to now based on INTEGRAL and Swift data. The flare spectra are well
described by a power-law model with a high energy cut-off at ~15 keV. The
absorption column density during the flares was found to be ~10^21 cm^-2,
indicating a very low matter density around the compact object. Using the
supergiant donor star parameters, the wind accretion conditions imply an
orbital period of the order of one year, a spin period of the order of hours
and a magnetic field of the order of 10^13 G.Comment: 5 pages, 2 figures, accepted for publication in Astrophysical Journal
Letter
GlycoDigest: a tool for the targeted use of exoglycosidase digestions in glycan structure determination
Summary: Sequencing oligosaccharides by exoglycosidases, either sequentially or in an array format, is a powerful tool to unambiguously determine the structure of complex N- and O-link glycans. Here, we introduce GlycoDigest, a tool that simulates exoglycosidase digestion, based on controlled rules acquired from expert knowledge and experimental evidence available in GlycoBase. The tool allows the targeted design of glycosidase enzyme mixtures by allowing researchers to model the action of exoglycosidases, thereby validating and improving the efficiency and accuracy of glycan analysis. Availability and implementation: http://www.glycodigest.org. Contact: [email protected] or [email protected]
- …