Baryon Density Correlations in High Temperature Hadronic Matter

As part of an ongoing effort to characterize the high temperature phase of QCD, in a numerical simulation using the staggered fermion scheme, we measure the quark baryon density in the vicinity of a fixed test quark at high temperature and compare it with similar measurements at low temperature and at the crossover temperature. We find an extremely weak correlation at high temperature, suggesting that small color singlet clusters are unimportant in the thermal ensemble. We also find that at $T = 0.75\ T_c$ the total induced quark number shows a surprisingly large component attributable to baryonic screening. A companion simulation of a simple flux tube model produces similar results and also suggests a plausible phenomenological scenario: As the crossover temperature is approached from below, baryonic states proliferate. Above the crossover temperature the mean size of color singlet clusters grows explosively, resulting in an effective electrostatic deconfinement.Comment: 26 pp, RevTeX, 12 postscript figures, combined in a single shell archive file. (Also available in 13 postscript files by anonymous ftp from einstein.physics.utah.edu, /pub/milc/paper.sh.Z.

Comparative Study of full QCD Hadron Spectrum and Static Quark Potential with Improved Actions

We investigate effects of action improvement on the light hadron spectrum and the static quark potential in two-flavor QCD for $a^{-1} \approx 1$ GeV and $m_{PS}/m_V = 0.7-0.9$. We compare a renormalization group improved action with the plaquette action for gluons, and the SW-clover action with the Wilson action for quarks. We find a significant improvement in the hadron spectrum by improving the quark action, while the gluon improvement is crucial for a rotationally invariant static potential. We also explore the region of light quark masses corresponding to $m_{PS}/m_V \geq 0.4$ on a 2.7 fm lattice using the improved gauge and quark action. A flattening of the potential is not observed up to 2 fm.Comment: LaTeX, 35 pages, 22 eps figures, uses revtex and eps

Lattice calculation of 1−+1^{-+} hybrid mesons with improved Kogut-Susskind fermions

We report on a lattice determination of the mass of the exotic $1^{-+}$ hybrid meson using an improved Kogut-Susskind action. Results from both quenched and dynamical quark simulations are presented. We also compare with earlier results using Wilson quarks at heavier quark masses. The results on lattices with three flavors of dynamical quarks show effects of sea quarks on the hybrid propagators which probably result from coupling to two meson states. We extrapolate the quenched results to the physical light quark mass to allow comparison with experimental candidates for the $1^{-+}$ hybrid meson. The lattice result remains somewhat heavier than the experimental result, although it may be consistent with the $\pi_1(1600)$.Comment: 24 pages, 12 figures. Replaced to match published versio

A new ghost cell/level set method for moving boundary problems:application to tumor growth

In this paper, we present a ghost cell/level set method for the evolution of interfaces whose normal velocity depend upon the solutions of linear and nonlinear quasi-steady reaction-diffusion equations with curvature-dependent boundary conditions. Our technique includes a ghost cell method that accurately discretizes normal derivative jump boundary conditions without smearing jumps in the tangential derivative; a new iterative method for solving linear and nonlinear quasi-steady reaction-diffusion equations; an adaptive discretization to compute the curvature and normal vectors; and a new discrete approximation to the Heaviside function. We present numerical examples that demonstrate better than 1.5-order convergence for problems where traditional ghost cell methods either fail to converge or attain at best sub-linear accuracy. We apply our techniques to a model of tumor growth in complex, heterogeneous tissues that consists of a nonlinear nutrient equation and a pressure equation with geometry-dependent jump boundary conditions. We simulate the growth of glioblastoma (an aggressive brain tumor) into a large, 1 cm square of brain tissue that includes heterogeneous nutrient delivery and varied biomechanical characteristics (white matter, gray matter, cerebrospinal fluid, and bone), and we observe growth morphologies that are highly dependent upon the variations of the tissue characteristics—an effect observed in real tumor growth

Topological susceptibility with the improved Asqtad action

As a test of the chiral properties of the improved Asqtad (staggered fermion) action, we have been measuring the topological susceptibility as a function of quark masses for 2 + 1 dynamical flavors. We report preliminary results, which show reasonable agreement with leading order chiral perturbation theory for lattice spacing less than 0.1 fm. The total topological charge, however, shows strong persistence over Monte Carlo time.Comment: Lattice2002(algor

Plasmid-Encoded Proinsulin Preserves C-Peptide While Specifically Reducing Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes

In type 1 diabetes (T1D) an intense inflammatory response destroys β cells in the pancreas, where insulin is produced and released. A therapy for T1D that reduces the specific autoimmune response in this disease while leaving the remainder of the immune system intact has long been sought. Proinsulin is a major target of adaptive immunity in T1D. We hypothesized that an engineered DNA plasmid encoding proinsulin (BHT-3021) would preserve β cell function in T1D patients through reduction of insulin-specific T cells. We studied 80 subjects over 18 years of age who were diagnosed with T1D within 5 years. Subjects were randomized 2:1 to receive intramuscular injections of BHT-3021 or BHT-placebo, weekly for 12 weeks, and then monitored for safety and immune responses in a blinded fashion. Four dose levels of BHT-3021 were evaluated: 0.3, 1.0, 3.0, and 6.0 mg. C-peptide served as an exploratory measure of efficacy and safety. Islet-specific CD8+ T cell frequencies were assessed with multimers of monomeric human leukocyte antigen class I molecules loaded with peptides containing pancreatic or unrelated antigens. No serious adverse events related to BHT-3021 occurred. C-peptide levels improved relative to placebo at all doses, most notably at 1 mg at 15 weeks (+19.5% BHT-3021 versus −8.8% BHT-placebo, P < 0.026). Proinsulin-reactive CD8+ T cells, but not T cells against unrelated islet or foreign molecules, declined in the BHT-3021 arm (P < 0.006). Thus, we demonstrate that a plasmid encoding proinsulin reduces the frequency of CD8+ T cells reactive to proinsulin while preserving C-peptide over the course of dosing

Etnobotânica e medicina popular no tratamento de malária e males associados na comunidade ribeirinha Julião – baixo Rio Negro (Amazônia Central)

RESUMO A utilização de plantas medicinais para o tratamento de doenças tropicais como a malária na Amazônia Central é de suma importância, principalmente em locais onde o sistema único de saúde não se encontra presente como na maioria das comunidades ribeirinhas desta região. Sendo assim, investigar e resgatar o conhecimento popular a respeito de plantas medicinais utilizadas no tratamento de malária e males associados pelos moradores da comunidade Julião situada na Reserva de Desenvolvimento Sustentável do Tupé, Manaus-AM, torna-se importante no registro de como as populações locais se previnem e tratam essa doença tão prevalente e perigosa na região. O trabalho foi conduzido na forma de oficinas participativas, segregadas por gênero e complementadas com entrevistas semiestruturadas aliadas à técnica da turnê-guiada nos quintais e floresta adjacente à comunidade. Foram calculados os índices de diversidade de Shannon-Wiener, equitabilidade e concordância quanto ao uso principal (CUP). A partir da colaboração efetiva de 13 comunitários foram registradas 62 espécies vegetais pertencentes a 53 gêneros e 34 famílias botânicas que resultaram em índice de diversidade (H’) de 1,62 decits e equitabilidade de 0,9. As famílias mais representativas foram: Fabaceae (7 espécies), Asteraceae e Lamiaceae (4 espécies cada) e Solanaceae e Rutaceae (3 espécies cada). Vale destacar que 16 espécies (25,8%) foram citadas para tratamento de malária e males associados pela primeira vez em estudos etnobotânicos realizados na América Latina