830 research outputs found
An Analysis of Recent Changes in Kansas Drunk Driving Laws
Full-text available at SSRN. See link in this record.For the past several years the problem of drunk driving has become of increasingly intense public concern. In response to this concern, the Kansas Legislature has passed major amendments to the drunk driving laws. The most recent amendments passed the legislature in 1985 in conjunction with changes in state liquor laws. The 1985 amendments offer a consolidated package that toughens criminal penalties and limits the opportunity for certain defendants to receive diversion. At the same time, the new laws expand the power of the police to act against persons suspected of drunk driving. These expanded powers affect both the circumstances under which the police can order suspects to undergo tests and the kinds of tests that can be ordered. This Article examines the changes in police procedure required by the new drunk driving laws. The Article first provides a general description of the recent changes and then analyzes some of the constitutional and practical problems those changes raise
Radiative Transitions in Charmonium from Lattice QCD
Radiative transitions between charmonium states offer an insight into the
internal structure of heavy-quark bound states within QCD. We compute, for the
first time within lattice QCD, the transition form-factors of various
multipolarities between the lightest few charmonium states. In addition, we
compute the experimentally unobservable, but physically interesting vector
form-factors of the and .
To this end we apply an ambitious combination of lattice techniques,
computing three-point functions with heavy domain wall fermions on an
anisotropic lattice within the quenched approximation. With an anisotropy
at we find a reasonable gross spectrum and a
hyperfine splitting , which compares favourably with
other improved actions.
In general, after extrapolation of lattice data at non-zero to the
photopoint, our results agree within errors with all well measured experimental
values. Furthermore, results are compared with the expectations of simple quark
models where we find that many features are in agreement; beyond this we
propose the possibility of constraining such models using our extracted values
of physically unobservable quantities such as the quadrupole moment.
We conclude that our methods are successful and propose to apply them to the
problem of radiative transitions involving hybrid mesons, with the eventual
goal of predicting hybrid meson photoproduction rates at the GlueX experiment.Comment: modified version as publishe
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Myocardial hypothermia increases autophagic flux, mitochondrial mass and myocardial function after ischemia-reperfusion injury.
Animal studies have demonstrated beneficial effects of therapeutic hypothermia on myocardial function, yet exact mechanisms remain unclear. Impaired autophagy leads to heart failure and mitophagy is important for mitigating ischemia/reperfusion injury. This study aims to investigate whether the beneficial effects of therapeutic hypothermia are due to preserved autophagy and mitophagy. Under general anesthesia, the left anterior descending coronary artery of 19 female farm pigs was occluded for 90 minutes with consecutive reperfusion. 30 minutes after reperfusion, we performed pericardial irrigation with warm or cold saline for 60 minutes. Myocardial tissue analysis was performed one and four weeks after infarction. Therapeutic hypothermia induced a significant increase in autophagic flux, mitophagy, mitochondrial mass and function in the myocardium after infarction. Cell stress, apoptosis, inflammation as well as fibrosis were reduced, with significant preservation of systolic and diastolic function four weeks post infarction. We found similar biochemical changes in human samples undergoing open chest surgery under hypothermic conditions when compared to the warm. These results suggest that autophagic flux and mitophagy are important mechanisms implicated in cardiomyocyte recovery after myocardial infarction under hypothermic conditions. New therapeutic strategies targeting these pathways directly could lead to improvements in prevention of heart failure
Treatment recommendations for psoriatic arthritis
Objective: To develop comprehensive recommendations for the treatment of the various clinical manifestations of psoriatic arthritis (PsA) based on evidence obtained from a systematic review of the literature and from consensus opinion. Methods: Formal literature reviews of treatment for the most significant discrete clinical manifestations of PsA (skin and nails, peripheral arthritis, axial disease, dactylitis and enthesitis) were performed and published by members of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA). Treatment recommendations were drafted for each of the clinical manifestations by rheumatologists, dermatologists and PsA patients based on the literature reviews and consensus opinion. The level of agreement for the individual treatment recommendations among GRAPPA members was assessed with an online questionnaire. Results: Treatment recommendations were developed for peripheral arthritis, axial disease, psoriasis, nail disease, dactylitis and enthesitis in the setting of PsA. In rotal, 19 recommendations were drafted, and over 80% agreement was obtained on 16 of them. In addition, a grid that factors disease severity into each of the different disease manifestations was developed to help the clinician with treatment decisions for the individual patient from an evidenced-based perspective. Conclusions: Treatment recommendations for the cardinal physical manifestations of PsA were developed based on a literature review and consensus between rheumatologists and dermatologists. In addition, a grid was established to assist in therapeutic reasoning and decision making for individual patients. It is anticipated that periodic updates will take place using this framework as new data become available
Time-dependent quantum many-body theory of identical bosons in a double well: Early time ballistic interferences of fragmented and number entangled states
A time-dependent multiconfigurational self-consistent field theory is
presented to describe the many-body dynamics of a gas of identical bosonic
atoms confined to an external trapping potential at zero temperature from first
principles. A set of generalized evolution equations are developed, through the
time-dependent variational principle, which account for the complete and
self-consistent coupling between the expansion coefficients of each
configuration and the underlying one-body wave functions within a restricted
two state Fock space basis that includes the full effects of the condensate's
mean field as well as atomic correlation. The resulting dynamical equations are
a classical Hamiltonian system and, by construction, form a well-defined
initial value problem. They are implemented in an efficient numerical
algorithm. An example is presented, highlighting the generality of the theory,
in which the ballistic expansion of a fragmented condensate ground state is
compared to that of a macroscopic quantum superposition state, taken here to be
a highly entangled number state, upon releasing the external trapping
potential. Strikingly different many-body matter-wave dynamics emerge in each
case, accentuating the role of both atomic correlation and mean-field effects
in the two condensate states.Comment: 16 pages, 5 figure
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