Implementación de los Pactos Mundiales: la importancia de un enfoque que abarque a toda la sociedad

La comunidad mundial debe adoptar ahora medidas incisivas y coordinadas mediante un enfoque que abarque a toda la sociedad para impulsar la implementación efectiva de los dos Pactos Mundiales

CONHECIMENTO DOS PROFESSORES DA ESCOLA ESTADUAL DE UM MUNICÍPIO DO INTERIOR DE RONDÔNIA SOBRE TRANSTORNO DE PERSONALIDADE BORDERLINE

O conceito de transtorno de personalidade borderline (TPB) surgiu em 1980, na qual deixou de ser considerada uma neurose-psicose, e passou a ser um transtorno de personalidade. Este estudo teve como objetivo identificar o conhecimento dos professores de um município do interior de Rondônia sobre transtorno de personalidade borderline. Trata-se de um estudo descritivo/ exploratório e comparativo de natureza quantitativo. Participaram 25 professores do ensino médio, totalizando 100% da população de maioria do sexo feminino, com media de idade de 41 anos, pardo e casados. Na primeira fase do estudo 07/25 docentes afirmaram conhecer o TPB , e na fase seguinte o aumento foi nítido com 23/25 tendo conhecimento sobre, também pode-se observar o aumento na quantidade das descrições sobre o transtorno, porem não na qualidade

Mitochondrial humanin peptide acts as a cytoprotective factor in granulosa cell survival

Humanin (HN) is a short peptide involved in many biological processes such as apoptosis, cell survival, inflammatory response, and reaction to stressors like oxidative stress, between others. In the ovary, a correct balance between pro- and anti-apoptotic factors is crucial for folliculogenesis. In the follicular atresia, survival or death of granulosa cells is a critical process. The goal of this study was to evaluate the action of HN on granulosa cell fate. To explore endogenous HN function in the ovary, we used a recombinant baculovirus (BV) encoding a short-hairpin RNA targeted to silence HN (shHN). HN downregulation modified ovarian histoarchitecture and increased apoptosis of granulosa cells. HN was also detected in a granulosa tumor cell line (KGN). Transduction of KGN cells with BV-shHN resulted in HN downregulation and increased apoptosis. On the other hand, treatment of KGN cells with exogenous HN increased cell viability and decreased apoptosis. In summary, these findings indicate that HN is a cytoprotective factor in granulosa cells of antral follicles, suggesting that this peptide would be involved in the regulation of folliculogenesis. Also, this peptide is a cytoprotective factor in KGN cells, and therefore, it could be involved in granulosa tumor cell behavior.Fil: Marvaldi, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Martin, Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Conte, Julia Gaetana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Gottardo, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina. Universidad Nacional de Quilmes; ArgentinaFil: Pidre, Matias Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; ArgentinaFil: Imsen, Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Irizarri, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Manuel, Sharron L.. Northwestern University; Estados UnidosFil: Duncan, Francesca E.. Northwestern University; Estados UnidosFil: Romanowski, Victor. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; ArgentinaFil: Seilicovich, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Jaita, Gabriela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentin

Implementing the Global Compacts: the importance of a whole-of-society approach

The global community must now take incisive, coordinated action through a whole-of-society approach to push forward the effective implementation of the two Global Compacts

Deconstructing the myth of the need for immigration detention

Immigration detention is broadly used by many countries around the world as a tool for so-called migration governance and as a deterrence measure against migrants, people seeking asylum, and other people on the move that are in another country’s territory. Immigration detention is also used as a mechanism to criminalize migrants alongside other measures such as deportations, externalization of borders, and pushbacks. This technique, which is contrary to human rights obligations toward migrant and refugee children’s rights and should not be used for people seeking asylum or for other vulnerable migrants, results in countless women, men, and children being detained often indefinitely and with little safeguards. Instead, consistent with advocacy by groups such as the International Detention Coalition, immigration detention should cease to be used as a practice at all. Many migrants and people seeking asylum are from the Global South adding another dimension to immigration detention which is its racialized nature. This chapter outlines the system of immigration detention and draws attention to the conditions and challenges faced by people who are affected by immigration detention or at risk of detention globally. Using the example of Australia it highlights the racist nature of the treatment of undocumented migrants, asylum seekers, and refugees in detention and queries whether a critical Whiteness lens can be useful in dismantling the immigration detention regime

Implementación de los Pactos Mundiales: la importancia de un enfoque que abarque a toda la sociedad

La comunidad mundial debe adoptar ahora medidas incisivas y coordinadas mediante un enfoque que abarque a toda la sociedad para impulsar la implementación efectiva de los dos Pactos Mundiales

A Potent Anti-Malarial Human Monoclonal Antibody Targets Circumsporozoite Protein Minor Repeats and Neutralizes Sporozoites in the Liver

International audienceDiscovering potent human monoclonal antibodies (mAbs) targeting the Plasmodium falciparum circumsporozoite protein (PfCSP) on sporozoites (SPZ) and elucidating their mechanisms of neutralization will facilitate translation for passive prophylaxis and aid next-generation vaccine development. Here, we isolated a neutralizing human mAb, L9 that preferentially bound NVDP minor repeats of PfCSP with high affinity while cross-reacting with NANP major repeats. L9 was more potent than six published neutralizing human PfCSP mAbs at mediating protection against mosquito bite challenge in mice. Isothermal titration calorimetry and multiphoton microscopy showed that L9 and the other most protective mAbs bound PfCSP with two binding events and mediated protection by killing SPZ in the liver and by preventing their egress from sinusoids and traversal of hepatocytes. This study defines the subdominant PfCSP minor repeats as neutralizing epitopes, identifies an in vitro biophysical correlate of SPZ neutralization, and demonstrates that the liver is an important site for antibodies to prevent malaria