Are older people at risk of sexually transmitted infections? A new look at the evidence

Two policy documents were published by the UK Department of Health in 2001 which established the service development agendas for their respective areas over the coming years. The National Service Framework (NSF) for Older People sets out national standards for ‘better, fairer and more integrated health and social care services for older people’ and ‘addresses conditions significant to older ages’ to promote ‘active and healthy aging’. The National Sexual Health Strategy identifies ways to ensure that that the sexual health of the UK population is maximized, predicated on the grounds that ‘our sexual health affects our physical and psychological well-being and is central to some of the most important and lasting relationships in our lives’. What is striking, if perhaps ultimately unsurprising, is that there is no overlap between the documents. The NSF for Older People makes no reference to sexuality or sexual health issues, and the National Sexual Health Strategy makes no reference to older people and, indeed, explicitly focuses on younger people, particularly through linking the prevention of sexually transmitted infections (STIs) with the reduction in teenage pregnancies

Static Einstein-Maxwell Solutions in 2+1 dimensions

We obtain the Einstein-Maxwell equations for (2+1)-dimensional static space-time, which are invariant under the transformation $q_0=i\,q_2,q_2=i\,q_0,\alpha \rightleftharpoons \gamma$. It is shown that the magnetic solution obtained with the help of the procedure used in Ref.~\cite{Cataldo}, can be obtained from the static BTZ solution using an appropriate transformation. Superpositions of a perfect fluid and an electric or a magnetic field are separately studied and their corresponding solutions found.Comment: 8 pages, LaTeX, no figures, to appear in Physical Review

Non-Perturbative Particle Dynamics

We construct a non-perturbative, single-valued solution for the metric and the motion of two interacting particles in ($2+1$)-Gravity, by using a Coulomb gauge of conformal type. The method provides the mapping from multivalued ( minkowskian ) coordinates to single-valued ones, which solves the non-abelian monodromies due to particles's momenta and can be applied also to the general N-body case.Comment: 11 pages, LaTeX, no figure

Barriers to providing palliative care for older people in acute hospitals

Background: the need for access to high-quality palliative care at the end of life is becoming of increasing public health concern. The majority of deaths in the UK occur in acute hospitals, and older people are particularly likely to die in this setting. However, little is known about the barriers to palliative care provision for older people within acute hospitals. Objective: to explore the perspectives of health professionals regarding barriers to optimal palliative care for older people in acute hospitals. Methods: fifty-eight health professionals participated in eight focus groups and four semi-structured interviews. Results: participants identified various barriers to palliative care provision for older people, including attitudinal differences to the care of older people, a focus on curative treatments within hospitals and a lack of resources. Participants also reported differing understandings of whose responsibility it was to provide palliative care for older people, and uncertainly over the roles of specialist and generalist palliative care providers in acute hospitals. Conclusions: numerous barriers exist to the provision of high-quality palliative care for older people within acute hospital settings. Additional research is now required to further explore age-related issues contributing to poor access to palliative care

Investigating Roles Of 2 Novel Eklf Targets Involved In Erythropoiesis

Erythrocytes are primarily comprised of the oxygen carrying protein hemoglobin. Genetic mutations causing defects in the proper synthesis of hemoglobin result in various anemias. It is during the last phases of terminal erythroid differentiation that hemoglobin levels rise, making it a focus for therapeutic research. Fetal hemoglobin is comprised of ⍺-globin and gamma globin, then after a change in gene expression called hemoglobin switching which takes place after birth, adult hemoglobin is comprised of ⍺-globin and beta globin. We investigated hemoglobin switching and erythroid terminal differentiation by focusing on the master erythroid transcription factor Erythroid Krüppel-like Factor (EKLF). Data led to identifying two novel EKLF targets. The first, Pumilio 1 (PUM1), is a protein that is known as a post transcriptional repressor and not been studied in erythrocytes until now. Our work indicates that PUM1 does indeed work as a post transcriptional repressor of -globin in adult cells. Data also shows that if PUM1 levels are lowered that -globin levels rise significantly without altering β-globin levels or stalling progression through erythroid terminal differentiation. Together, this data shows that PUM1 mediated post-transcriptional regulations has a significant role in hemoglobin switching and could serve as an excellent therapeutic target since the induction of -globin has been shown to ameliorate symptoms of hemoglobinopathies. The second EKLF target investigated is Inner Centromere Protein (INCENP). This protein has a major role in lining up chromosomes and microtubules for successful cytokinesis. This preliminary investigation showed that there is an increase in ploidy when INCENP levels are lower in erythroid cells

Statistical properties of classical gravitating particles in (2+1) dimensions

We report the statistical properties of classical particles in (2+1) gravity as resulting from numerical simulations. Only particle momenta have been taken into account. In the range of total momentum where thermal equilibrium is reached, the distribution function and the corresponding Boltzmann entropy are computed. In the presence of large gravity effects, different extensions of the temperature turn out to be inequivalent, the distribution function has a power law high-energy tail and the entropy as a function of the internal energy presents a flex. When the energy approaches the open universe limit, the entropy and the mean value of the particle kinetic energy seem to diverge.Comment: Latex2e (amssymb) file, 17 page

Unbound Universe

Astronom

Likelihood of death within one year among a national cohort of hospital inpatients in Scotland

No abstract available