Quality control parameters of Gandhakadi Yoga tablets W. S. R. To its microscopic evaluation

Gandhakadi Yoga is a formulation suggested for Loha Sevanajanya Vikara Prashamana (Iron overload) in Ayurveda Prakasha and can be used as iron chelator which might help to decrease the iron overload. The present study was carried out to standardize the finished product Gandhakadi Yoga tablets for confirmation of its identity, quality and purity. Thus a trial was made to establish the Quality assessing parameters for Gandhakadi Yoga tablets by simple microscopic technique. The characters i.e. black debris of Gandhaka treated with Bhringaraja, light yellow brown content of Gandhaka, fragment of spongy parenchyma of Agastya leaf, oil globules and epicarp cells with tannin content of Vidanga etc. were the characteristic features of the finished product

ADOPTING INNOVATIVE METHOD AND COMPARATIVE EVALUATION OF SWETHA PARPATI MENTIONED IN AYURVEDIC LITERATURE

In Ayurveda, the study of the therapeutic uses and effects of drugs means Pharmaco-therapeutic is described under the branch of Rasashastra which mainly incorporates inorganic, herbo-mineral and metallic pharmaceutical preparations namely Khalviya Rasayana, Parpati Rasayana, Pottali Rasayana and Kupipakwa Rasayana. This article aims for the comparative assessment of Swethaparpati coming under Parpatikalpa mentioned as per reference of Sidhayogasangraha, AFI with another reference of Rasodharatantra. According to the first two references the ingredients used for the preparation are Suryakshara, Sphatika and Navasadara and as per the third reference ingredients like Tankana and Karpura are added. Here a detailed review of literature has been collected regarding the potential of the above mentioned individual ingredients along with the recent research updates regarding individual ingredients used in the production of Swetha Parpati according to both the references it also incorporate research updates on the formulation Swetha Parpati. This article also aims pharmaceutical standardization of standard method adopted in process of production of Swethaparpati with the alteration made from the usual method adopted in preparation of Parpati Kalpana that will help for developing new improved SOP regarding the formulation. This paper also aims in projecting the improved therapeutic value which could be generated by addition of new ingredients mentioned as per reference of Rasodharatantra

A CRITICAL AYURVEDIC LITERARY REVIEW OF THE PLANT PANASA (ARTOCARPUS HETEROPHYLLUS LAM.)

Panasa (Artocarpus heterophyllus Lam), the well known jackfruit tree is widely distributed all over the world. It is a treasure trove of various ethnomedical uses which are yet to be proven scientifically. Its fruit is very delicious and its leaves, root, latex, seed and wood are reported to have many medicinal properties. Though the plant is renowned for its nutritive values, the useful parts of the plant with rich medicinal values are less utilized for medicinal purposes. The plant is well described in Ayurvedic classics where prime importance has been given to its fruit whereas least references are available concerned to its other useful parts especially the leaf. This forms the literature gap concerned with this drug that hinders its further clinical researches. A compiled review of the classical literature of Panasa is not yet available as a ready reference. Hence it is a herculean task for the researcher to compile the literature which is scattered in various classical books of different era. In this work focus has been made to compile the literature of the plant Panasa (Artocarpus heterophyllus Lam) from the Ayurvedic classics. As this work provides the literature of this plant under a single roof it will be helpful for the scholars in future research works

Ayurvedic management of Thalassemia Major-A review of clinical researches conducted at IPGT & RA, Jamnagar

Thalassemia Major is the most common single gene disorder which represents a major health burden worldwide. The available treatment modalities in conventional medicine i.e. blood transfusion (BT) and iron chelation therapies are associated with complications while bone marrow transplantation etc. are out of reach of many. Present study is aimed to highlight the effective role of Ayurvedic medicines i.e. Dhatri Avaleha, Triphaladi Avaleha and Musta-Triphaladi Avaleha in the management of Thalassemia Major. Till date total five clinical researches have been carried out on Thalassemia Major at PG level in the department of Kaumarbhritya at IPGT&RA, Jamnagar. In which a simple random sampling method was followed. Patients were divided into two groups, Group A (Trial group with Ayurvedic drug intervention and BT) and Group B (Control Group with BT and iron chelation therapy). Assessment was done based on the subjective and objective parameters after completion of treatment. The data obtained in clinical studies was analyzed by using suitable statistical tests. The trial drugs were found to be effective on subjective, objective criteria, BT interval and general health status of Thalassemic patients as well as clinically safe

Imminium ion chemistry at C-2 of pyroglutamates: Unexpected formation of 1,4- Methano-3-oxa-6-t-butyl-7 -azabicyc1o[7.3.0]decan-2,8-dione^†

154-158α-Bromination of the cyclically protected S-pyroglutamic acid, its subsequent reactions with nucleophillic reagents via corresponding N-acylimminium intermediate is described

Management of Postoperative Hypoxaemia in Patients Following Upper Abdominal Laparoscopic Surgery. - A Comparative Study

Noninvasive ventilation has been shown to reduce acute postoperative hypoxaemia, with significant reduction in the incidence of re-intubation, complications and a trend towards lower mortality. The aim of the study was to determine the effectiveness of CPAP vs venturi therapy in early achievement of oxygenation goals and in prevention of re-intubation for management of postoperative hypoxaemia following laparoscopic cholecystectomy. Forty adult patients of ASA physical status I& II, scheduled for elective laparoscopic cholecystectomy, those were unable to maintain SpO2 > 95% breathing room air after extubation, were recruited for a prospective, randomized comparative study. Patients with PaO2 / FiO2 between 250 and 300 were included in the study and were randomly allocated to one of the two groups to receive oxygen therapy either using a CPAP of 10 cm of water and a FiO2 of 0.5 (Group A) or using a venturi mask of FiO2 of 0.5 (Group B) . All patients were observed postoperatively upto 18 h and were screened by ABG analyses at 6, 12 and 18 h of treatment. SpO2, ECG, heart rate, respiratory rate, temperature and NIBP were monitored throughout the study period. Patients in Group A showed significant improvement in early achievement of adequate oxygenation than those in Group B, although, due to intolerance to CPAP therapy two patients in Group A needed reintubation to maintain adequate oxygenation. To conclude, oxygenation using continuous positive airway pressure is a safe and effective means in improving gas exchange to treat acute postoperative hypoxaemia in conscious and cooperative patients