The Problems of Defining the Legal Status of Individuals Involved in a Civil Proceedings’ Case

In the context of reforming the procedural legislation, the emergence of new types of proceedings, diversity and rapid development of material and procedural legal relations actualized the problem of determining the status of individuals involved in the case in civil proceedings. It is noted the need to determine the legal status of the parties to the writ proceedings, specifying the role of the Prosecutor in the process, the legal status of the subjects referred to in articles 46 and 47 of the Civil procedure code of the Russian Federation, including the Commissioner and persons not involved in the case, in respect of which a court decision resolved the issue of their rights or obligations. In the context of unification of the civil process, the recommendations aimed at improving the civil procedural legislation that determines the legal status of individuals involved in the case in the civil process are proposed

Psychological features of personal development of younger adolescents in the process of leisure activities

The article presents the results of analysis of younger adolescents’ psychological characteristics and provides a description of a comprehensive program created in order to ensure effective personal development of children in this age group in the process of carrying out leisure activities. To test the program, a sample was formed consisting of 60 adolescents studying at Municipal Budgetary General Education Institution “School No. 134” in Nizhny Novgorod. The results of the study indicate significant changes among all criteria analyzed for the experimental and the control groups. The scientific significance of the data obtained lies in the expansion of the idea of younger adolescents’ personal qualities’ multidimensionality and the opportunity provided to study the phenomenon in more detail. Indicators obtained during the course of the study can be used to organise extracurricular activities for adolescents, hold seminars and personal development trainings as well as develop methodological manuals on personality psychology

La institucionalización de los principios de creación de leyes como una forma de transformar las categorías científicas en las soluciones de creación de leyes

La institucionalización de los principios de creación de la ley es la tarea más importante del estado que se otorga a la formación orientada hacia la creación de la ley, para hacer cumplir el propósito social y las formas de desarrollo del estado legalment

Profile of antiphospholipid antibodies and complement system in COVID-19 patients of different severity

COVID-19, a severe acute respiratory syndrome caused by SARS-CoV-2, may predispose to thrombotic events, especially when combined with antiphospholipid antibodies (aPL). However, there are limited data on prevalence and antigenic specificity of aPL in COVID-19. Complement activation is assumed to play an important role in pathogenesis of COVID-19-associated coagulopathy. During the SARS-CoV-2 pandemic, it is necessary to identify important biomarkers for predicting severe course of COVID-19 and risk of thrombotic complications. Our objective was to evaluate the aPL profile, quantitative content and activity of complement and its components in COVID-19 patients graded by severity in the course of time. IgM and IgG antibodies to cardiolipin (CL), phosphatidylserine (PS), β2-glycoprotein-I (β2-GP-I), prothrombin (PT), annexin V (An V), as well as C1q complement component, content of its C3 and C4 components and total complement activity were determined in blood serum using ELISA approach. 141 patients with COVID-19 were included in the study. Group 1 consisted of 39 patients with mild form, group 2 (65 patients) presented with moderate form, and group 3 included 37 patients with severe form of COVID-19. Blood samples were obtained on day 3-7 of the disease (1st point) and after 14-28 days (2nd point). The results were as follows: aPL were detected in 29.1% of the total COVID-19 cohort, frequency of aPL detection by the severity grade did not differ (33.3%, 24.6% and 32.4%). In 8.5% of the patients, aPL were detected only at the 1st time point; in 14.2%, only at the 2nd point; and in 6.4% of the cases, at the both time points. Antibodies to PT (16.3%) and An V (11.3%) were revealed more frequently. The detection frequency of antibodies to PT was significantly higher than antibodies to CL and PS (7.1%), β2-GP-I (7.8%). The prevalence of aPL in groups 1 and 3 did not differ. At the 1st point in group 3, increased levels of C4 (89.2%) and C3 (24.3%) in blood, and a decrease in complement activity (35.1%) were more often observed than in group 1. At the 2nd time point in group 3, a decrease in complement activity was often detected (59.5%). The C3 levels exceeding 720 μg/ml were found to predict a 2.6-fold increased risk of severe COVID-19, and this risk became 3.3 times higher at C4 levels of > 740 μg/ml. The antibodies to PT and An V are often detected in COVID-19 patients, along with low prevalence of antibodies to CL and β2-GP-I. These antibodies can be involved in pathogenesis of COVID-19-associated coagulopathy, being detectable at the late stage of the disease, and they may trigger APS in predisposed patients and reconvalescents. Although presence of aPL antibodies is not associated with COVID-19 severity, their persistence over the period of convalescence may be an additional risk factor for thromboembolic complications. The COVID-19 patients are characterized by activation of the complement system, which increases in severe cases, and manifests with increased or decreased levels of C3 complement component, increased levels of C4 component in blood, and a decreased total complement activity. Quantitative determination of C3 and C4 complement components over the period of COVID-19 progression is of prognostic value, with respect to severity of the disease

The prognostic significance of the omental chemotherapy response score in hereditary ovarian tumors after neoadjuvant chemotherapy

The study was aimed to evaluate histopathological tumor response of omental metastases in BRCA1-associated and sporadic ovarian tumors after platinum-based neoadjuvant chemotherapy (nACT). We selected patients with histologically confirmed ovarian high-grade serous carcinoma who were treated with nACT followed by optimal debulking. Forty patients (14 BRCA1-associated cancers and 26 sporadic cases) meeting the criteria mentioned above were enrolled in the pathological examination. Clinical data (platinum-free interval, PFI) were collected through database review. Good regress [score 3] was observed in 4 out of 16 (25%) BRCA1-associated carcinomas and in one of 24 (4%) sporadic cancers (p = 0.14, Fisher's exact test). PFI was associated with the degree of response (minimal regress – median PFI 3.62 months, moderate regress – median 8.17 months, good regress - 21.28 months, p = 0.026, Kruskal-Wallis test). The omental response score predicted platinum-free interval in BRCA1-associated tumors (score 2+3 vs. 1; median PFI, 18.6 vs. 2.9 months; p = 0.04, Mann–Whitney U test). Histopathological tumor response of omental metastasis in BRCA1-associated and sporadic ovarian tumors after platinum-based neoadjuvant chemotherapy predicts PFI.Целью данного исследования стало сравнение выраженности патоморфологического регресса метастазов в большой сальник BRCA1-ассоциированных и спорадических опухолей яичника в ответ на платиносодержащую неоадъювантную химиотерапию (НАХТ). В исследование включены 40 пациенток (16 больных с мутацией BRCA1 и 24 «спорадических» случаев) в соответствии с следующими критериями: серозный гистотип опухоли высокой степени злокачественности, платиносодержащая НАХТ, оптимальная циторедуктивная операция (ОЦО), известная длительность бесплатинового интервала (БПИ). При оценке гистопатологического регресса метастазов в большой сальник в группе BRCA1-ассоциированного рака яичника РЯ частота выраженных регрессов [3 балла] составила 4/16 (25%), в группе спорадических опухолей – 1/24 (4%) (p = 0,14, точный критерий Фишера). Продолжительность БПИ достоверно зависела от степени регресса (при минимальном регрессе медиана составила 3,62 мес., при умеренном – 8,17 мес., при выраженном – 21,28 мес.; p = 0,026, тест краскела-Уоллиса). В группе носителей мутаций BRCA1 наблюдалось различие в продолжительности БПИ между случаями с умеренным и выраженным регрессом и случаями с минимальным регрессом (медианы 18,6 мес. vs. 2,9 мес., соответственно; p = 0,04, критерий Манна-Уитни). Степень выраженности патоморфологического регресса метастазов в большой сальник BRCA1-ассоциированных и спорадических опухолей яичника в ответ на НАХТ после ОЦО коррелирует с продолжительностью БПИ

Rapid selection of BRCA1-proficient tumor cells during neoadjuvant therapy for ovarian cancer in BRCA1 mutation carriers

Ovarian carcinomas (OC) often demonstrate rapid tumor shrinkage upon neoadjuvant chemotherapy (NACT). However, complete pathologic responses are very rare and the mechanisms underlying the emergence of residual tumor disease remain elusive. We hypothesized that the change of somatic BRCA1 status may contribute to this process. The loss-of-heterozygosity (LOH) at the BRCA1 locus was determined for 23 paired tumor samples obtained from BRCA1 germ-line mutation carriers before and after NACT. We observed a somatic loss of the wild-type BRCAI allele in 74% (17/23) of OCs before NACT. However, a retention of the wild-type BRCA1 copy resulting in a reversion of LOH status was detected in 65% (11/17) of those patients after NACT. Furthermore, we tested 3 of these reversion samples for LOH at intragenic BRCA1single nucleotide polymorphisms (SNPs) and confirmed a complete restoration of the SNP heterozygosity in all instances. The neoadjuvant chemotherapy for BRCA1-associated OC is accompanied by a rapid expansion of pre-existing BRCA1-proficient tumor clones suggesting that continuation of the same therapy after NACT and surgery may not be justified even in patients initially experiencing a rapid tumor regression. (C) 2017 Elsevier B.V. All rights reserved.Peer reviewe

High frequency of BRCA1, but not CHEK2 or NBS1 (NBN), founder mutations in Russian ovarian cancer patients

<p>Abstract</p> <p>Background</p> <p>A significant portion of ovarian cancer (OC) cases is caused by germ-line mutations in BRCA1 or BRCA2 genes. BRCA testing is cheap in populations with founder effect and therefore recommended for all patients with OC diagnosis. Recurrent mutations constitute the vast majority of BRCA defects in Russia, however their impact in OC morbidity has not been yet systematically studied. Furthermore, Russian population is characterized by a relatively high frequency of CHEK2 and NBS1 (NBN) heterozygotes, but it remains unclear whether these two genes contribute to the OC risk.</p> <p>Methods</p> <p>The study included 354 OC patients from 2 distinct, geographically remote regions (290 from North-Western Russia (St.-Petersburg) and 64 from the south of the country (Krasnodar)). DNA samples were tested by allele-specific PCR for the presence of 8 founder mutations (BRCA1 5382insC, BRCA1 4153delA, BRCA1 185delAG, BRCA1 300T>G, BRCA2 6174delT, CHEK2 1100delC, CHEK2 IVS2+1G>A, NBS1 657del5). In addition, literature data on the occurrence of BRCA1, BRCA2, CHEK2 and NBS1 mutations in non-selected ovarian cancer patients were reviewed.</p> <p>Results</p> <p>BRCA1 5382insC allele was detected in 28/290 (9.7%) OC cases from the North-West and 11/64 (17.2%) OC patients from the South of Russia. In addition, 4 BRCA1 185delAG, 2 BRCA1 4153delA, 1 BRCA2 6174delT, 2 CHEK2 1100delC and 1 NBS1 657del5 mutation were detected. 1 patient from Krasnodar was heterozygous for both BRCA1 5382insC and NBS1 657del5 variants.</p> <p>Conclusion</p> <p>Founder BRCA1 mutations, especially BRCA1 5382insC variant, are responsible for substantial share of OC morbidity in Russia, therefore DNA testing has to be considered for every OC patient of Russian origin. Taken together with literature data, this study does not support the contribution of CHEK2 in OC risk, while the role of NBS1 heterozygosity may require further clarification.</p

КЛИНИКО-МОРФОЛОГИЧЕСКИЕ ОСОБЕННОСТИ НАСЛЕДСТВЕННОГО РАКА ЯИЧНИКА

Germ-line mutations in BRCA1 and BRCA2 genes are the most established risk factors for hereditary breast and ovarian cancers. The purpose of the study was to analyze BRCA1/2 testing in ovarian cancer patients. Materials and methods. We analyzed 222 patients with ovarian cancer (OC) who underwent genetic testing. Results. Recurrent Slavic mutations in these genes were detected in 60/222 (27%) patients.104 patients lacked any clinical signs of hereditary form of the disease, however BRCA1/2 genetic defects were identified among 11 (11%) of these women. BRCA1/2-associated carcinomas were characterized by more advanced stage at diagnosis and predominance of high-grade serous histological tumor subtype. Conclusion. These results emphasize the need for BRCA1/2 testing for all patients with OC. BRCA1/2-associated carcinomas have clinical and pathological cgaracteristics, which should be considered while planning therapy. Наследственные мутации в генах BRCA1 и BRCA2 являются наиболее известными и изученными факторами риска карцином молочной железы и яичника. Цель исследования – анализ опыта BRCA1/2- тестирования больных раком яичника. Материал и методы. Проанализированы данные 222 больных раком яичника (РЯ), направленных на генетическое тестирование. Результаты. Генетический дефект в генах BRCA1/2 был выявлен у 60 (27 %) из 222 пациенток. В группе женщин без клинических признаков наследственной формы заболевания генетические дефекты BRCA1/2 были обнаружены у 11 (11 %) из 104 пациенток. BRCA1/2-ассоциированные карциномы характеризовались более поздней стадией заболевания и преобладанием низкодифференцированного серозного гистологического типа опухоли. Заключение. BRCA1/2-ассоциированные опухоли составляют значимую часть злокачественных новообразований яичника, что обусловливает целесообразность генетического тестирования для всех пациенток с РЯ. BRCA1/2-ассоциированные карциномы имеют клинические и морфологические особенности, которые необходимо учитывать при планировании терапии.

Economic Expertise in Executive Immunity Cases on a Residential Premise Which Is an Only One for Living

The goal is to study the issue of conducting expertise in cases of depriving executive (property) immunity to a premise owned by the debtor if it is the only premises suitable for permanent residence for him and his family members. The following tasks are being solved: the history of legal regulation and law enforcement practice on the issue of granting executive immunity to a premise is investigated, primarily the positions of the Constitutional Court of the Russian Federation; the possibility and (or) necessity of conducting expert examinations in such cases are revealed, including the question of the type of expert examination; the circumstances of the case are determined, which can be confirmed by the conclusion of the economic examination, and the questions that can be asked to the experteconomist.Цель заключается в исследовании вопроса о проведении экспертизы в делах о лишении исполнительского (имущественного) иммунитета на жилое помещение (его части), принадлежащее должнику на праве собственности, если для него и членов его семьи оно является единственным пригодным для постоянного проживания помещением. Для этого решаются следующие задачи: исследуется история правового регулирования и правоприменительной практики по вопросу о предоставлении исполнительского иммунитета на единственное жилое помещение, прежде всего позиции Конституционного Суда РФ; выявляется возможность и (или) необходимость проведения экспертиз в таких делах, в том числе вопрос о виде экспертизы; определяются обстоятельства дела, которые могут быть подтверждены заключением экономической экспертизы, и вопросы, которые могут быть заданы эксперту- экономисту

Legal Mechanisms for Solving Problems of Application of Applied Artificial Intelligence in The Provision of Services

The goal is to develop proposals for the formation of legal mechanisms for solving problems related to the use of applied artificial intelligence in the provision of services. The following tasks are solved: the concept of applied artificial intelligence, its use in the business sector in the provision of services, general problems of the use of artificial intelligence, problems of its use in the provision of services are identified, legal mechanisms for solving these problems are developed. Results. The main problems of using applied artificial intelligence in the provision of services by business companies that require legal regulation are identified: problems associated with the formation of biased opinions about employees, partners, customers based on algorithms and ratings, algorithm errors, manipulation of consumer behaviour with algorithms, use of information about consumer to the detriment of his interests. Legal mechanisms for solving problems are proposed: simplified contestation of decisions, the introduction of legal presumptions, the extension of the legal regime of public contracts to new areas of services, other legal mechanisms for increased legal protection of interested parties, the introduction of a legislative ban on the collection of redundant information by Internet companies, formation of the legal status of consumer communities in the Internet spheres, development at the level of self-regulation of rules for feedback on complaints, the inclusion of provisions for improvements in agreements with software developers.Цель заключается в выработке предложений по формированию правовых механизмов решения проблем, связанных с использованием прикладного искусственного интеллекта при оказании услуг. Для этого решаются следующие задачи: исследуется понятие прикладного искусственного интеллекта, его использование в бизнес-сфере при оказании услуг, общие проблемы применения искусственного интеллекта, выявляются проблемы его использования при оказании услуг, вырабатываются правовые механизмы решения этих проблем. Результаты. Выявлены основные проблемы использования прикладного искусственного интеллекта при оказании услуг бизнес компаниями, требующие правового регулирования: проблемы, связанные с формированием на основе алгоритмов и рейтингов предвзятого мнения о работниках, партнерах, клиентах, ошибки алгоритмов, манипулирование поведением потребителей с помощью алгоритмов, использование информации о потребителе в ущерб его интересам. Предложены правовые механизмы решения проблем: упрощенное оспаривание принятых решений, введение правовых презумпций, распространение правового режима публичных договоров на новые сферы оказания услуг, другие правовые механизмы повышенной правовой защиты заинтересованных лиц, введение законодательного запрета на собирание избыточной информации интернет-компаниями, формирование правового статуса сообществ потребителей в интернет-сфере, разработка на уровне саморегулирования правил обратной связи в качестве реакции на жалобы, включение положений о доработках в договоры с разработчиками программного обеспечения