Dendritic transport. II. Somatofugal movement of neuronal lysosomes induced by colchicine: evidence for a novel transport system in dendrites.

The effect of colchicine injections on the ultrastructural localization of dipeptidyl peptidase II (Dpp II) was studied in the mitral cells of the rat olfactory bulb. In control animals, electron-dense reaction product representing Dpp II activity was observed in lysosomes, lipofuscin granules, short cisternae located close to the granular endoplasmic reticulum, and dense granules. Lysosomes and lipofuscin granules were the most intensely stained organelles. Dpp II-containing organelles were localized mainly to the cell body and were randomly distributed in the perikaryal cytoplasm. Twenty-four hours after a 100-micrograms intracerebroventricular colchicine injection, the distribution of Dpp II-containing organelles was drastically altered. Short cisternae and dense granules containing Dpp II reaction product were noticeably absent in these preparations. Lysosomes and lipofuscin granules were depleted from the perikaryal cytoplasm and were concentrated in dendrites. Lysosomes were observed to extend for considerable distances in dendrites where they acquired elongated and dumbbell shapes. The shapes of some of these labeled lysosomes gave the impression that they were actively being "pulled" into the dendrites. These results indicate that microtubules sequester lysosomes to the perikaryal cytoplasm and suggest the presence of a novel transport system responsible for the movement of lysosomes from the cell body to the dendrites

On the number of prime order subgroups of finite groups

Let G be a finite group and let ?(G) be the number of prime order subgroups of G. We determine the groups G with the property ?(G)??G?/2?1, extending earlier work of C. T. C. Wall, and we use our classification to obtain new results on the generation of near-rings by units of prime order

Hadron Spectra and QGP Hadronization in Au+Au Collisions at RHIC

The transverse mass spectra of Omega hyperons and phi mesons measured recently by STAR Collaboration in Au+Au collisions at sqrt(s_NN) = 130 GeV are described within a hydrodynamic model of the quark gluon plasma expansion and hadronization. The flow parameters at the plasma hadronization extracted by fitting these data are used to predict the transverse mass spectra of J/psi and psi' mesons.Comment: 4 pages, 4 figures, Fig. 3 correcte

Open Charm Enhancement in Pb+Pb Collisions at SPS

The statistical coalescence model for the production of open and hidden charm is considered within the canonical ensemble formulation. The data for the J/\psi multiplicity in Pb+Pb collisions at 158 A GeV are used for the model prediction of the open charm yield. We find a strong enhancement of the open charm production, by a factor of about 2--4, over the standard hard-collision model extrapolation from nucleon-nucleon to nucleus-nucleus collisions. A possible mechanism of the open charm enhancement in A+A collisions at the SPS energies is proposed.Comment: 4 pages, Late

Multiplicity fluctuations in relativistic nuclear collisions

Multiplicity distributions of hadrons produced in central nucleus-nucleus collisions are studied within the hadron-resonance gas model in the large volume limit. In the canonical ensemble conservation of three charges (baryon number, electric charge, and strangeness) is enforced. In addition, in the micro-canonical ensemble energy conservation is included. An analytical method is used to account for resonance decays. Multiplicity distributions and scaled variances for negatively charged hadrons are presented along the chemical freeze-out line of central Pb+Pb (Au+Au) collisions from SIS to LHC energies. Predictions obtained within different statistical ensembles are compared with preliminary NA49 experimental results on central Pb+Pb collisions in the SPS energy range. The measured fluctuations are significantly narrower than a Poisson reference distribution, and clearly favor expectations for the micro-canonical ensemble.Comment: 6 pages, 3 figure

Dendritic transport. I. Colchicine stimulates the transport of lysosomal enzymes from cell bodies to dendrites.

Injection of colchicine into the lateral cerebral ventricle of the rat was found to induce a paradoxical translocation of two lysosomal enzymes, dipeptidyl peptidase II (Dpp II) and acid phosphatase, from the soma of neurons to the dendrites. Following a single injection of colchicine, neuronal somata, which normally contain the bulk of these lysosomal enzymatic activities, become depleted of these enzymes, whereas dendrites become abnormally enriched. All neurons which contained these enzymes, except those of the mesencephalic nucleus of the trigeminal nerve, displayed this phenomenon. Lysosomal enzyme translocation into dendrites was observed in the mitral cell layer within 1 hr after a colchicine injection and could be induced in most neuronal populations by injections of colchicine as low as 25 micrograms. Five days after a 100-micrograms colchicine injection, a normal pattern of enzyme distribution was observed, indicating that the effect of colchicine was reversible. Enzyme translocation was not accompanied by gross changes in cell morphology, nor did it result in the specific loss of neuronal cell bodies which contained these enzymes. The results indicate that colchicine, under conditions known to inhibit axoplasmic transport, stimulates the transport of lysosomal enzymes from the cell body to the dendrites

Chemical freeze-out parameters at RHIC from microscopic model calculations

The relaxation of hot nuclear matter to an equilibrated state in the central zone of heavy-ion collisions at energies from AGS to RHIC is studied within the microscopic UrQMD model. It is found that the system reaches the (quasi)equilibrium stage for the period of 10-15 fm/$c$. Within this time the matter in the cell expands nearly isentropically with the entropy to baryon ratio $S/A = 150 - 170$. Thermodynamic characteristics of the system at AGS and at SPS energies at the endpoints of this stage are very close to the parameters of chemical and thermal freeze-out extracted from the thermal fit to experimental data. Predictions are made for the full RHIC energy $\sqrt{s} = 200$ AGeV. The formation of a resonance-rich state at RHIC energies is discussed.Comment: Talk at the conference Quark Matter'2001, 4 pages, to appear in Nucl. Phys.

The High E_T Drop of J/psi to Drell-Yan Ratio from the Statistical c anti-c Coalescence Model

The dependence of the J/psi yield on the transverse energy E_T in heavy ion collisions is considered within the statistical c anti-c coalescence model. The model fits the NA50 data for Pb+Pb collisions at the CERN SPS even in the high-E_T region (E_T > 100 GeV). Here E_T-fluctuations and E_T-losses in the dimuon event sample naturally create the celebrated drop in the J/psi to Drell-Yan ratio.Comment: 14 pages, REVTeX, 1 PS-figure. v2: References are corrected and update

Dynamics of strange, charm and high momentum hadrons in relativistic nucleus-nucleus collisions

We investigate hadron production and attenuation of hadrons with strange and charm quarks (or antiquarks) as well as high transverse momentum hadrons in relativistic nucleus-nucleus collisions from 2 AGeV to 21.3 ATeV within two independent transport approaches (UrQMD and HSD). Both transport models are based on quark, diquark, string and hadronic degrees of freedom, but do not include any explicit phase transition to a quark-gluon plasma. From our dynamical calculations we find that both models do not describe the maximum in the $K^+/\pi^+$ ratio at 20 - 30 AGeV in central Au+Au collisions found experimentally, though the excitation functions of strange mesons are reproduced well in HSD and UrQMD. Furthermore, the transport calculations show that the charmonium recreation by $D+\bar{D} \to J/\Psi + meson$ reactions is comparable to the dissociation by 'comoving' mesons at RHIC energies contrary to SPS energies. This leads to the final result that the total $J/\Psi$ suppression as a function of centrality at RHIC should be less than the suppression seen at SPS energies where the 'comover' dissociation is substantial and the backward channels play no role. Furthermore, our transport calculations -- in comparison to experimental data on transverse momentum spectra from $pp$, d+Au and Au+Au reactions -- show that pre-hadronic effects are responsible for both the hardening of the hadron spectra for low transverse momenta (Cronin effect) as well as the suppression of high $p_T$ hadrons. The mutual interactions of formed hadrons are found to be negligible in central Au+Au collisions at $\sqrt{s}$ = 200 GeV for $p_T \geq$ 6 GeV/c and the sizeable suppression seen experimentally is attributed to a large extent to the interactions of 'leading' pre-hadrons with the dense environment.Comment: 10 pages, incl. 7 postscript figures, invited talk presented at the 25th Course "Heavy Ion Reactions from Nuclear to Quark Matter", Erice, Sept. 16-24, 2003, to be publ. in Prog. Part. Nucl. Phy