e-Mental Health in Central Massachusetts

e-Mental Health in Central Massachusetts (EMH) is a web-based resource designed to improve access to evidence-based mental health information and local resources for mental health professionals and consumers. The Lamar Soutter Library, University of Massachusetts Medical School (UMMS), in collaboration with the UMMS Department of Psychiatry and the Commonwealth of Massachusetts Department of Mental Health, developed EMH to meet the needs of practitioners, patients and caregivers. The project provides an integrative web-based information resource that includes searchable databases of (1) local mental health care services and (2) quality-filtered information about mental health conditions and diseases. Centralized access to professional resources, information literacy training, professional reference services and document delivery to a traditionally underserved population are also provided. After training, participants in the program use the resource regularly and demonstrate heightened awareness of reliable mental health information available to them. The collaborative spirit also continues and will surely benefit future endeavors

The Academic Medical Library as Online Publisher

Objectives: To describe the use of an institutional repository system to facilitate the publishing activities of an academic medical library. Methods: The Library launched its institutional repository in 2006 and developed a mature collection of peer-reviewed articles, posters, and conference proceedings. Beginning in 2009, the Library sought to expand the use of the repository and partnered with two academic departments, Neurology and Psychiatry, to publish electronic journals. In spring 2011 the Library began to explore the idea of publishing its own peer-reviewed, open access electronic journal. Planning and implementation considerations included: choosing a unique and appropriate name; infrastructure and hosting options; organizational and governance structure; roles and responsibilities; journal structure and content; aims and scope; editorial, peer review and other policies and procedures; and dissemination. Simultaneously the Library undertook the publishing of its first electronic book, where issues of presentation, page turning, photo placement, and indexing became significant. Results: The inaugural issue of the Journal of eScience Librarianship was published on February 15, 2012 via the journal management platform of the Library’s institutional repository, eScholarship@UMMS. JESLIB has been assigned ISSN 2161-3974. The medical school joined CrossRef so that article metadata could be deposited into their system and each article assigned a DOI (Digital Object Identifier). Additional issues have been published, readership statistics and patterns are positive, and JESLIB is now indexed in the Directory of Open Access Journals. In fall 2012, the Library published its first eBook, “A History of the University of Massachusetts Medical School, which was authored by the medical school’s head of the Office of Medical History and Archives. Conclusions: Academic medical libraries can successfully publish as well as host online journals and books. Utilizing the institutional repository for publishing purposes offers a number of advantages. The repository provides a tested infrastructure for ingesting and sharing of documents. The repository administrator possesses strong in-house expertise, experience with embargoes, metadata, preservation and dissemination, and most importantly, has built strong relationships and trust with faculty and researchers. The open access platform leads to wider dissemination and maximum impact, backed up by reliable usage statistics. Helpful planning guides and other resources are available to assist libraries and academic groups in publishing open access peer-reviewed materials. Lessons learned include: utilize professional copy editing services; locking papers for revisions speeds up workflows

So You Want to Be a Publisher: Planning and Publishing the Journal of eScience Librarianship

Objective: To describe the planning process and activities of the University of Massachusetts Medical School\u27s Lamar Soutter Library around the publication of the new Journal of eScience Librarianship (JESLIB). Methods: The University of Massachusetts Medical School’s Lamar Soutter Library through funding from the National Network of Libraries of Medicine has been a leader in educating librarians about eScience and its impact on librarianship. In spring 2011 the Library began to explore the idea of publishing a peer-reviewed, open access electronic journal about eScience and data management for librarians. Planning and implementation considerations included: choosing a unique and appropriate name; infrastructure and hosting options; organizational and governance structure; roles and responsibilities; journal structure and content; aims and scope; editorial, peer review and other policies and procedures; and dissemination. Results: The inaugural issue of the Journal of eScience Librarianship (http://escholarship.umassmed.edu/jeslib/) was published on February 15, 2012 via the journal management platform of the Library\u27s institutional repository, eScholarship@UMMS. JESLIB has been assigned ISSN 2161-3974. The medical school joined CrossRef so that article metadata could be deposited into their system and each article assigned a DOI (Digital Object Identifier). Conclusion: Libraries can successfully publish as well as host online journals. Helpful planning guides and other resources are available to assist libraries and academic groups in publishing open access peer-reviewed journals. Lessons learned include: consider professional copy editing services to assist the Editorial Board; Editorial Team roles and responsibilities should be clearly defined but allow room for flexibility; and have a clear marketing communication and promotion strategy

Building an e-Science Portal for Librarians: A Model of Collaboration

The e-Science Portal for New England Librarians (http://esciencelibrary.umassmed.edu) is an openly accessible website targeted specifically for librarians working in research institutions that generate, share, store and/or use data for basic scientific research in the health, biological, and physical sciences. The portal provides links to information on e-Science, e-Science librarianship, current practices, and science disciplines. The portal’s e-Science Community blog http://esciencecommunity.umassmed.edu serves as a bulletin and discussion forum for the latest news, upcoming events, and commentaries. While the portal was originally developed to provide e-Science information to New England Librarians, its openly accessible content is relevant to librarians interested in networked science worldwide. Content for the e-Science Portal for New England Librarians is contributed by a team of nine content editors who are science and medical librarians from diverse New England research libraries. Each content editor identifies, annotates, and aggregates links to resources for a designated focus area of the portal and submits them to the portal’s project coordinator for further review. Following this review, the project coordinator and the portal development team plan the organization and layout of the content in the relevant subject web pages of the portal. The effective collaboration among the content editors and the portal design team has been crucial to the development of an e-Science Portal that provides the essential resources and tools needed by librarians engaging in networked science. The focus of this paper is the model of collaboration adopted by the portal’s design team and content editors

RTOG 0518: Randomized Phase III Trial to Evaluate Zoledronic Acid for Prevention of Osteoporosis and Associated Fractures in Prostate Cancer Patients

Background: RTOG 0518 evaluated the potential benefit of zoledronic acid therapy in preventing bone fractures for patients with high grade and/or locally advanced, non-metastatic prostate adenocarcinoma receiving luteinizing hormone-releasing hormone (LHRH) agonist and radiotherapy (RT). Methods: Eligible patients with T-scores of the hip ( −2.5 vs. > −1.0) and negative bone scans were prospectively randomized to either zoledronic acid, 4 mg, concurrently with the start of RT and then every six months for a total of 6 infusions (Arm 1) or observation (Arm 2). Vitamin D and calcium supplements were given to all patients. Secondary objectives included quality of life (QOL) and bone mineral density (BMD) changes over a period of three years. Results: Of 109 patients accrued before early closure, 96 were eligible. Median follow-up was 36.3 months for Arm I and 34.8 months for Arm 2. Only two patients experienced a bone fracture (1 in each arm) resulting in no difference in freedom from any bone fracture (p=0.95), nor in QOL. BMD percent changes from baseline to 36 months were statistically improved with the use of zoledronic acid compared to observation for the lumbar spine (6% vs. −5%, p<0.0001), left total hip (1% vs. −8%, p=0.0002), and left femoral neck (3% vs. −8%, p=0.0007). Conclusions: For patients with advanced, non-metastatic prostate cancer receiving LHRH agonist and RT, the use of zoledronic acid was associated with statistically improved BMD percent changes. The small number of accrued patients resulted in decreased statistical power to detect any differences in the incidence of bone fractures or QOL

Predictive response-relevant clustering of expression data provides insights into disease processes

This article describes and illustrates a novel method of microarray data analysis that couples model-based clustering and binary classification to form clusters of ;response-relevant' genes; that is, genes that are informative when discriminating between the different values of the response. Predictions are subsequently made using an appropriate statistical summary of each gene cluster, which we call the ;meta-covariate' representation of the cluster, in a probit regression model. We first illustrate this method by analysing a leukaemia expression dataset, before focusing closely on the meta-covariate analysis of a renal gene expression dataset in a rat model of salt-sensitive hypertension. We explore the biological insights provided by our analysis of these data. In particular, we identify a highly influential cluster of 13 genes-including three transcription factors (Arntl, Bhlhe41 and Npas2)-that is implicated as being protective against hypertension in response to increased dietary sodium. Functional and canonical pathway analysis of this cluster using Ingenuity Pathway Analysis implicated transcriptional activation and circadian rhythm signalling, respectively. Although we illustrate our method using only expression data, the method is applicable to any high-dimensional datasets

Gendered Risk Perceptions Associated with Human-Wildlife Conflict: Implications for Participatory Conservation

This research aims to foster discourse about the extent to which gender is important to consider within the context of participatory approaches for biological conservation. Our objectives are to: (1) gender-disaggregate data about stakeholders' risk perceptions associated with human-wildlife conflict (HWC) in a participatory conservation context, and (2) highlight insights from characterizing gendered similarities and differences in the way people think about HWC-related risks. Two communal conservancies in Caprivi, Namibia served as case study sites. We analyzed data from focus groups (n = 2) to create gendered concept maps about risks to wildlife and livelihoods and any associations of those risks with HWC, and semi-structured interviews (n = 76; men = 38, women = 38) to measure explicit risk attitudes associated with HWC. Concept maps indicated some divergent perceptions in how groups characterized risks to wildlife and livelihoods; however, not only were identified risks to wildlife (e.g., pollution, hunting) dissimilar in some instances, descriptions of risks varied as well. Study groups reported similar risk perceptions associated with HWC with the exception of worry associated with HWC effects on local livelihoods. Gendered differences in risk perceptions may signal different priorities or incentives to participate in efforts to resolve HWC-related risks. Thus, although shared goals and interests may seem to be an obvious reason for cooperative wildlife management, it is not always obvious that management goals are shared. Opportunity exists to move beyond thinking about gender as an explanatory variable for understanding how different groups think about participating in conservation activities

Screening for ovarian cancer in women with varying levels of risk, using annual tests, results in high recall for repeat screening tests.

BACKGROUND: We assessed ovarian cancer screening outcomes in women with a positive family history of ovarian cancer divided into a low-, moderate- or high-risk group for development of ovarian cancer. METHODS: 545 women with a positive family history of ovarian cancer referred to the Ovarian Screening Service at the Royal Marsden Hospital, London from January 2000- December 2008 were included. They were stratified into three risk-groups according to family history (high-, moderate- and low-risk) of developing ovarian cancer and offered annual serum CA 125 and transvaginal ultrasound screening. The high-risk group was offered genetic testing. RESULTS: The median age at entry was 44 years. The number of women in the high, moderate and low-risk groups was 397, 112, and 36, respectively. During 2266 women years of follow-up two ovarian cancer cases were found: one advanced stage at her fourth annual screening, and one early stage at prophylactic bilateral salpingo-oophorectomy (BSO). Prophylactic BSO was performed in 138 women (25.3%). Forty-three women had an abnormal CA125, resulting in 59 repeat tests. The re-call rate in the high, moderate and low-risk group was 14%, 3% and 6%. Equivocal transvaginal ultrasound results required 108 recalls in 71 women. The re-call rate in the high, moderate, and low-risk group was 25%, 6% and 17%. CONCLUSION: No early stage ovarian cancer was picked up at annual screening and a significant number of re-calls for repeat screening tests was identified.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are