Dilaton in a Multicritical 3+epsilon-D Parity Violating Field Theory

The multi-critical behaviour of an approximately scale and conformal invariant quantum field theory, which can be regarded as the deformation of the critical Gross-Neveu model in 3+epsilon dimensions by a nearly marginal parity violating operator, is studied using a large $N$ expansion. When epsilon is greater than a number of order 1/N, the deformation is marginally relevant and it is found to exhibit spontaneous breaking of the approximate scale symmetry accompanied by the appearance of a light scalar in its spectrum. The scalar mass is parametrically small, of order epsilon times the fermion mass and it can be identified with a light dilaton. When the dimension is reduced to 3 the deformation of the Gross-Neveu model becomes marginally irrelevant, what was a minimum of the potential becomes a maximum and the theory has a non-perturbative global instability. There is a metastable perturbative phase where the scalar does not condense and the fermions are massless separated by an energy barrier with height of order one (rather than N) from an energetically favoured phase with a runaway condensate

A preliminary investigation of the use of throttles for emergency flight control

A preliminary investigation was conducted regarding the use of throttles for emergency flight control of a multiengine aircraft. Several airplanes including a light twin-engine piston-powered airplane, jet transports, and a high performance fighter were studied during flight and piloted simulations. Simulation studies used the B-720, B-727, MD-11, and F-15 aircraft. Flight studies used the Lear 24, Piper PA-30, and F-15 airplanes. Based on simulator and flight results, all the airplanes exhibited some control capability with throttles. With piloted simulators, landings using manual throttles-only control were extremely difficult. An augmented control system was developed that converts conventional pilot stick inputs into appropriate throttle commands. With the augmented system, the B-720 and F-15 simulations were evaluated and could be landed successfully. Flight and simulation data were compared for the F-15 airplane

Conformal symmetry and deflationary gas universe

We describe the ``deflationary'' evolution from an initial de Sitter phase to a subsequent Friedmann-Lema\^{\i}tre-Robertson-Walker (FLRW) period as a specific non-equilibrium configuration of a self-interacting gas. The transition dynamics corresponds to a conformal, timelike symmetry of an ``optical'' metric, characterized by a refraction index of the cosmic medium which continously decreases from a very large initial value to unity in the FLRW phase.Comment: 10 pages, to appear in "Exact Solutions and Scalar Fields in Gravity: Recent Developments", ed. by A. Macias, J. Cervantes-Cota, and C. L\"ammerzahl, Kluwer Academic Publishers 200

Model systems in SDHx-related pheochromocytoma/paraganglioma

Pheochromocytoma (PHEO) and paraganglioma (PGL) (together PPGL) are tumors with poor outcomes that arise from neuroendocrine cells in the adrenal gland, and sympathetic and parasympathetic ganglia outside the adrenal gland, respectively. Many follow germline mutations in genes coding for subunits of succinate dehydrogenase (SDH), a tetrameric enzyme in the tricarboxylic acid (TCA) cycle that both converts succinate to fumarate and participates in electron transport. Germline SDH subunit B (SDHB) mutations have a high metastatic potential. Herein, we review the spectrum of model organisms that have contributed hugely to our understanding of SDH dysfunction. In Saccharomyces cerevisiae (yeast), succinate accumulation inhibits alpha-ketoglutarate-dependent dioxygenase enzymes leading to DNA demethylation. In the worm Caenorhabditis elegans, mutated SDH creates developmental abnormalities, metabolic rewiring, an energy deficit and oxygen hypersensitivity (the latter is also found in Drosophila melanogaster). In the zebrafish Danio rerio, sdhb mutants display a shorter lifespan with defective energy metabolism. Recently, SDHB-deficient pheochromocytoma has been cultivated in xenografts and has generated cell lines, which can be traced back to a heterozygous SDHB-deficient rat. We propose that a combination of such models can be efficiently and effectively used in both pathophysiological studies and drug-screening projects in order to find novel strategies in PPGL treatment

Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2

Deficiency of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) in humans leads to the syndrome of apparent mineralocorticoid excess (SAME), in which cortisol illicitly occupies mineralocorticoid receptors, causing sodium retention, hypokalemia, and hypertension. However, the disorder is usually incompletely corrected by suppression of cortisol, suggesting additional and irreversible changes, perhaps in the kidney. To examine this further, we produced mice with targeted disruption of the 11β-HSD2 gene. Homozygous mutant mice (11β-HSD2(–/–)) appear normal at birth, but ∼50% show motor weakness and die within 48 hours. Both male and female survivors are fertile but exhibit hypokalemia, hypotonic polyuria, and apparent mineralocorticoid activity of corticosterone. Young adult 11β-HSD2(–/–) mice are markedly hypertensive, with a mean arterial blood pressure of 146 ± 2 mmHg, compared with 121 ± 2 mmHg in wild-type controls and 114 ± 4 mmHg in heterozygotes. The epithelium of the distal tubule of the nephron shows striking hypertrophy and hyperplasia. These histological changes do not readily reverse with mineralocorticoid receptor antagonism in adulthood. Thus, 11β-HSD2(–/–) mice demonstrate the major features of SAME, providing a unique rodent model to study the molecular mechanisms of kidney resetting leading to hypertension. J. Clin. Invest. 103:683–689 (1999

Prevalence of secondary care multimorbidity in mid-life and its association with premature mortality in a large longitudinal cohort study

Objectives Multimorbidity is the coexistence of two or more health conditions in an individual. Multimorbidity in younger adults is increasingly recognised as an important challenge. We assessed the prevalence of secondary care multimorbidity in mid-life and its association with premature mortality over 15 years of follow-up, in the Aberdeen Children of the 1950s (ACONF) cohort. Method A prospective cohort study using linked electronic health and mortality records. Scottish ACONF participants were linked to their Scottish Morbidity Record hospital episode data and mortality records. Multimorbidity was defined as two or more conditions and was assessed using healthcare records in 2001 when the participants were aged between 45 and 51 years. The association between multimorbidity and mortality over 15 years of follow-up (to ages 60–66 years) was assessed using Cox proportional hazards regression. There was also adjustment for key covariates: age, gender, social class at birth, intelligence at age 7, secondary school type, educational attainment, alcohol, smoking, body mass index and adult social class. Results Of 9625 participants (51% males), 3% had multimorbidity. The death rate per 1000 person-years was 28.4 (95% CI 23.2 to 34.8) in those with multimorbidity and 5.7 (95% CI 5.3 to 6.1) in those without. In relation to the reference group of those with no multimorbidity, those with multimorbidity had a mortality HR of 4.5 (95% CI 3.4 to 6.0) over 15 years and this association remained when fully adjusted for the covariates (HR 2.5 (95% CI 1.5 to 4.0)). Conclusion Multimorbidity prevalence was 3% in mid-life when measured using secondary care administrative data. Multimorbidity in mid-life was associated with premature mortality

Cosmological thermodynamics and deflationary gas universe

We establish a general thermodynamic scheme for cosmic fluids with internal self-interactions and discuss equilibrium and non-equilibrium aspects of such systems in connection with (generalized) symmetry properties of the cosmological dynamics. As an example we construct an exactly solvable gas dynamical model of a ``deflationary'' transition from an initial de Sitter phase to a subsequent Friedmann-Lema\^{\i}tre-Robertson-Walker (FLRW) period. We demonstrate that this dynamics represents a manifestation of a conformal symmetry of an ``optical'' metric, characterized by a specific effective refraction index of the cosmic medium.Comment: 12 pages, to appear in PR

Supplementation strategies for lactating dairy cows offered very high quality grass silages: Starch-based or fibre-based concentrates offered with or without straw

Publication history: Accepted - 13 February 2020; Published online - 15 February 2020.A three-period change-over design study using 24 mid-lactation multiparous Holstein-Friesian dairy cows, examined supplementation strategies for a high quality grass silage (dry matter (DM), 418 g/kg; crude protein (CP), 170 g/kg DM; metabolisable energy (ME), 12.1 MJ/kg DM). Four treatments, in a 2 × 2 factorial arrangement, compared concentrate type (High-starch or High-fibre) and straw inclusion (Straw or No-straw). Concentrates had a starch and neutral detergent fibre content of 373 and 258 g/kg DM, respectively (Highstarch), and 237 and 339 g/kg DM, respectively (High-fibre). In the No-straw treatments, silage and concentrates were offered as a total mixed ration in a 57:43 DM ratio. In the Straw treatments, chopped straw was added at 4% of total DM, replacing part of the silage component of the diet. Following this study, the effect of diet on nutrient utilisation efficiency was examined using four cows/treatment. There were no interactions between concentrate type and straw inclusion for any cow performance or digestibility parameters. Silage dry matter intake (DMI) and total DMI were reduced with the High-fibre concentrate (P = 0.001 and P = 0.006, respectively) and straw inclusion (P < 0.001 and P = 0.014, respectively). Neither concentrate type nor straw inclusion had a significant effect on milk yield or milk fat content. The High-starch concentrate increased milk protein content (P < 0.001), while straw inclusion decreased milk protein content (P = 0.036). Treatment had no effect on cow body weight, condition score, faecal scores, digestibility coefficients or nitrogen and energy utilisation efficiency. In conclusion, supplementing a high quality grass silage with a carefully formulated ‘high starch’ concentrate improved DMI and milk protein content with no adverse effects on cow performance. Straw inclusion in the diet had no beneficial effects on DMI, milk production or nutrient utilisation efficiency.This project was funded by Department of Agriculture, Environment and Rural Affairs (DAERA) in Northern Ireland, and by AgriSearch (Farmers Levy)