Predication of Drug Target Interaction using Reliable Multicast Routing in Wireless Ad hoc Molecular Network

Wireless Ad hoc Molecular network consists of atoms in terms of nodes in the absence of administrative point. In this connection, there is a need to adopt molecular analogy to define the architecture. Prediction of Drug Target Interaction (DTI) is a major impact in molecular ad hoc network. Efforts were made to combine such information with data to define DTI and to construct biological space. The concept of Conditional Random Field (CRF) is used in our proposed reliable multicast routing to integrate genomic, chemical and functional data to predict DTI. Reliability of links was also maintained to increase the network performance. Based on the extensive simulation results, the proposed reliable routing protocol achieves better performance than existing schemes

Recoganisation and security guidance of data integrity in cloud storage

Cloud computing has been envisioned as the de-facto solution to the rising storage costs of IT Enterprises. With the high costs of data storage devices as well as the rapid rate at which data is being generated it proves costly for enterprises or individual users to frequently update their hardware. Storage outsourcing of data to cloud storage helps such firms by reducing the costs of storage, maintenance and personnel. It can also assure a reliable storage of important data by keeping multiple copies of the data thereby reducing the chance of losing data by hardware failures. The study deal with the problem of implementing a protocol for obtaining a proof of data possession in the cloud sometimes referred to as Proof of irretrievability (POR). The problem tries to obtain and verify a proof that the data that is stored by a user at remote data storage in the cloud (called cloud storage archives or simply archives) is not modified by the archive and thereby the integrity of the data is assured. The verification systems prevent the cloud storage archives from misrepresenting or modifying the data stored at it without the consent of the data owner by using frequent checks on the storage archives.&nbsp

Performance Improvement for Reconfigurable Processor System Design in IoT Health Care Monitoring Applications

This research focuses on critical hardware components of an Internet of Things (IoT) system for reconfigurable processing systems. Single-Instruction Multiple-Data (SIMD) processors have recently been utilized to preprocess data at energy-constrained sensor nodes or IoT gateways, saving significant energy and bandwidth for transmission. Using traditional CPU-based systems to implement machine learning algorithms is inefficient in terms of energy consumption. In the proposed method Single-Instruction Multiple-Data (SIMD) processors are assembled by scaling the largest possible operand value subunits into direct access to the internal memory, where the carry output of each unit is conditionally fed into the next unit based on the implementation of the SIMD Processor design for Internet of Things applications. Each method has evaluated sub-operations that contribute considerably to the overall potential of the design. If the single register file can complete the intended action, a zero (one)-signal is applied to each unit\u27s carry input. Multiplexers combine two or more adders, sending the carry signal from one unit into another if additional units are necessary to compute the sum. The outcome results compare high-speed end device techniques in terms of area and power consumption. The proposed SIMD processor-based IoT healthcare monitoring system with a MIMD processor\u27s performance analysis of comparison clearly demonstrates that the system produces decent outcomes. The suggested system has an area overhead of 85 m2, a power usage of 4.10 W, and a time delay of 20 ns

Performance Improvement for Reconfigurable Processor System Design in IoT Health Care Monitoring Applications

This research focuses on critical hardware components of an Internet of Things (IoT) system for reconfigurable processing systems. Single-Instruction Multiple-Data (SIMD) processors have recently been utilized to preprocess data at energy-constrained sensor nodes or IoT gateways, saving significant energy and bandwidth for transmission. Using traditional CPU-based systems to implement machine learning algorithms is inefficient in terms of energy consumption. In the proposed method Single-Instruction Multiple-Data (SIMD) processors are assembled by scaling the largest possible operand value subunits into direct access to the internal memory, where the carry output of each unit is conditionally fed into the next unit based on the implementation of the SIMD Processor design for Internet of Things applications. Each method has evaluated sub-operations that contribute considerably to the overall potential of the design. If the single register file can complete the intended action, a zero (one)-signal is applied to each unit\u27s carry input. Multiplexers combine two or more adders, sending the carry signal from one unit into another if additional units are necessary to compute the sum. The outcome results compare high-speed end device techniques in terms of area and power consumption. The proposed SIMD processor-based IoT healthcare monitoring system with a MIMD processor\u27s performance analysis of comparison clearly demonstrates that the system produces decent outcomes. The suggested system has an area overhead of 85 m2, a power usage of 4.10 W, and a time delay of 20 ns

Strengthening of Load Bearing Masonry Wall Panels with Externally Bonded Precast Textile Reinforced Concrete Laminate

241-245Textile Reinforced Concrete (TRC) has gained worldwide popularity as a strengthening material for masonry structures in the recent years. As of today, the application of TRC for masonry strengthening is either by cast-in-place methodology or by spraying method. The present work is a first-of-its kind study, which explores the feasibility of using externally bonded precast TRC laminate for strengthening of load bearing brick masonry wall panels. The binder used in TRC itself is used as adhesive for adhering the TRC laminate to masonry wall panels. Experimental investigations were carried out on unstrengthened and strengthened brick masonry wall panels under axial compression and combined axial compression and shear loading. The influence of TRC strengthening system is assessed by examining the performance indicators such as strength, stiffness and deformation. Based on the investigations, the use of externally bonded precast TRC laminate is found to be a feasible solution to strengthen brick masonry walls to have the required structural adequacy

FACTORIAL STUDIES ON ENHANCEMENT OF DISSOLUTION RATE AND FORMULATION OF ACECLOFENAC TABLETS EMPLOYING Î’CDAND KOLLIPHOR HS15

Aceclofenac is an effective anti inflammatory and analgesic drug. It belongs to class II under Biopharmaceutical classification system and exhibit low and variable oral bioavailability due to its poor solubility. It is practically insoluble in water and aqueous fluids and its oral absorption is dissolution rate limited. It needs enhancement in solubility and dissolution rate for improvement of its oral bioavailability and therapeutic efficacy. The objective of the present study is to enhance the dissolution rate and formulation development of aceclofenac tablets with fast dissolution characteristics employing βCD and Kolliphor HS15, a non ionic surfactant. The individual and combined effects of βCD (factor A) and Kolliphor HS15 (factor B) on the dissolution rate of aceclofenac from solid inclusion complexes and their tablets were evaluated in a series of 22 factorial experiments. The feasibility of formulating aceclofenac - βCD-Kolliphor HS15 inclusion complexes into tablets with fast dissolution rate characteristics was also investigated. Kolliphor HS15 has not been investigated earlier for this purpose. The individual and combined effects of βCD and Kolliphor HS15 in enhancing the dissolution rate and dissolution efficiency of aceclofenac from solid inclusion complexes and their tablets were highly significant (P < 0.01). The dissolution of aceclofenac was rapid and higher in the case of aceclofenac- βCD and aceclofenac- βCD - Kolliphor HS15 complexes prepared when compared to aceclofenac pure drug. β CD alone gave a 8.66 fold increase and in combination with Kolliphor HS15 it gave 9.85 fold increase in the dissolution rate of (K1) of aceclofenac. Aceclofenac –βCD – Kolliphor HS15 inclusion complexes could be formulated into compressed tablets by wet granulation method and the resulting tablets also gave rapid and higher dissolution of aceclofenac. Aceclofenac tablets formulated with βCD and Kolliphor HS15 individually gave 4.75 and 6.1 fold increase in the dissolution rate and those containing drug - βCD -Kolliphor HS15 complex gave much higher enhancement (21.35 fold) in the dissolution rate when compared to tablets formulated with aceclofenac pure drug. Combination of βCD and Kolliphor HS15 gave much higher enhancement in the dissolution rate of aceclofenac tablets than is possible with them individually. A combination of βCD with Kolliphor HS15 is recommended to enhance the dissolution rate in the formulation development of aceclofenac tablets with fast dissolution rate characteristics

A Review on Bacteriophage Mediated Control of Phytopathogenic Bacteria for Plant Protection

Bacteriophage therapy entails the application of bacteriophage viruses for the remedy of bacterial infections, a practice that has persisted for well over a century. Despite its enduring presence, the implementation of this therapeutic approach has faced persistent challenges, even though it has garnered support for over 25 years from microbiologists and physicians who perceive it as propitious remedy in the context of the escalating threat posed by anti-microbial resistance (AMR). The underlying justifications for these ongoing challenges are intricate in nature. This article aims to delve into the impact of bacteriophages on phytopathogens in the realm of plant biology. It endeavors to elucidate how bacteriophages function as potent antimicrobial agents in the management of bacterial infections afflicting plants, highlighting their reliability in comparison to synthetic antibiotics employed to mitigate such infections. It is worth noting that synthetic antibiotics occasionally falter in their efforts to curb or eradicate disease-causing bacteria. These microorganisms often exhibit a vigorous opposition to microbicides and various antibiotic drugs. Some bacteria even display resistance to colistin, rendering them multi-drug resistant (MDR), extensively drug-resistant (XDR), or even pan-drug resistant (PDR). In the relentless battle against these formidable bacterial foes, bacteriophage therapy emerges as a beacon of hope, offering promising results in the eradication of phytopathogenic bacteria and the suppression of further bacterial infections. This innovative phage therapy represents a significant milestone in the field of microbiolog

Evaluation of 5 Novel protein biomarkers for the rapid diagnosis of pulmonary and extra-pulmonary tuberculosis: preliminary results

Improved methods are required for the early and accurate diagnosis of tuberculosis, especially in the patients with smear-negative disease. Several biomarkers have been tried but most have shown poor sensitivity or specificity. In present study we aimed to evaluate the diagnostic utility of five novel antigens identified earlier by us. This is an initial study conducted on 250 subjects. The five recombinant antigens, named as rSS1 (Rv2145c), rSS2 (Rv0164), rSS3 (Rv1437), rSS4 (Rv1827) and rSS5 (Rv2970c), were expressed in pQE-30 expression vector, purified and their sero-diagnostic efficacy was evaluated in an unblinded manner using dot-blot and ELISA methods. The sensitivity and specificity of these novel antigens were compared with commercially available standard esat6 and 38 kDa antigens. Bacteriologically confirmed TB patients, non-TB disease controls and healthy individuals were included. which are based on novel antigen or novel technology, Area under curve (AUC) of the selected antigens were 0.98 (0.98–0.99) for rSS1, 0.88 (0.84–0.92) for rSS2, 0.88 (0.84–0.92) for rSS3, 0.95 (0.93–0.98) for rSS4 and 0.99 (0.98–1.0) for rSS5. Receiver operative characteristic (ROC) curve showed highly significant difference between TB and healthy subjects (p = <0.001). These initial findings, show that the recombinant antigens rSS1, rSS4 and rSS5 could be used as highly potential biomarkers for the serological diagnosis of active TB

Riboflavin carrier protein: a serum and tissue marker for breast carcinoma

We have earlier shown that the estrogen-modulated riboflavin carrier protein (RCP) first isolated from the chicken egg is evolutionarily conserved in mammals and is elaborated by lactating mammary gland as demonstrated with rat mammary epithelial cells in culture and confirmed by isolation of the vitamin carrier from bovine milk. In view of several earlier reports that many milk proteins as well as other estrogen-inducible proteins are up-regulated and secreted into circulation in animal models and in women with neoplastic breast disease, we analyzed serum RCP levels in a double-blind study using a specific radioimmunoassay in pre- and post-menopausal women with clinically diagnosed breast cancer at early and advanced stages of the disease and compared these levels with those in normal age-matched control volunteers. Our data reveal that the serum RCP levels in cycling breast cancer patients are 3- to 4-fold higher (p &lt; 0.01) than those in their normal counterparts. This difference in circulatory RCP levels between cancer patients and their age-matched normal counterparts is further magnified to 9- to 11-fold (p &lt; 0.005) at the post-menopausal stage. In addition, there seems to be a good correlation between rising RCP levels and disease progression, since significantly higher RCP concentrations (p &lt; 0.005) are encountered in patients with advanced metastasizing breast cancer versus those with early disease. Using specific monoclonal antibodies, RCP could be localized immunohistochemically in the cytoplasm of invading neoplastic cells of lobular and ductal carcinomas of the breast, indicating that the malignant cells are probably the source of the elevated serum RCP levels in breast cancer. These findings suggest that measurement of circulatory RCP and the immunohistochemical staining pattern of RCP in biopsy specimens could be exploited as an additional marker in diagnosis/prognosis of breast cancer in women