Feasibility of intercalated graphite railgun armatures

Graphite intercalation compounds may provide an excellent material for the fabrication of electro-magnetic railgun armatures. As a pulse of power is fed into the armature the intercalate could be excited into the plasma state around the edges of the armature, while the bulk of the current would be carried through the graphite block. Such an armature would have the desirable characteristics of both diffuse plasma armatures and bulk conduction armatures. In addition, the highly anisotropic nature of these materials could enable the electrical and thermal conductivity to be tailored to meet the specific requirements of electromagnetic railgun armatures. Preliminary investigations were performed in an attempt to determine the feasibility of using graphite intercalation compounds as railgun armatures. Issues of fabrication, resistivity, stability, and electrical current spreading are addressed for the case of highly oriented pyrolytic graphite

Constitutional Implications of School Punishment for Cyber Bullying

In this article, we address the scope of student free speech rights as it relates to cyber bullying. We provide a review of legal theories under which school administrators can address cyber bullying while still respecting student free speech rights and the First Amendment. Additionally, we address the jurisdiction of administrators to deal with off-campus bullying conduct

Cyber Bullying and Free Speech: Striking an Age-Appropriate Balance

Cyber bullying has generally been dealt with by the courts using one of two legal analyses: the “true threats” doctrine, or the Tinker substantial disruption test. This law review, the Cleveland State Law Review, recently published Anti-Cyber Bullying Statutes: Threat to Student Free Speech (referred to herein as “the Threat to Speech article”), which addressed these two theories, and argued that the current evolution of cyber bullying legislation simply goes too far. For example, Hayward states Anti-cyber bullying laws are the greatest threat to student speech because they seek to censor it anytime it occurs, using “substantial disruption” of school activities as justification and often based only on mere suspicion of potential disruption. The Threat to Speech article advocates greater protection of student speech. While we recognize that any regulation of speech by the state may raise First Amendment concerns, we are not so quick to conclude that cyber bullying regulations “chill student free speech.” Our analysis of the law leads us to the conclusion that school administrators have relatively broad discretion to regulate student speech, provided those regulations either serve legitimate pedagogical ends or protect the rights of other students and the school environment. Indeed, as we will demonstrate below, the evolution of the Supreme Court’s student free speech jurisprudence has followed the trend of granting more and more leeway to administrators. Contrary to the claims in the Threat to Speech article, in our opinion that leeway clearly extends to allowing regulation of speech which originates off campus but has a reasonable likelihood of making its way on campus. We also believe that, in addition to true threats and the Tinker substantial disruption standard described in the Threat to Speech article, school administrators may also regulate student speech consistent with the Court’s holding in Fraser—which set what we refer to as the “fundamental values standard” —and based on the fighting words doctrine

Cyber Bullying and Free Speech: Striking an Age-Appropriate Balance

Cyber bullying has generally been dealt with by the courts using one of two legal analyses: the “true threats” doctrine, or the Tinker substantial disruption test. This law review, the Cleveland State Law Review, recently published Anti-Cyber Bullying Statutes: Threat to Student Free Speech (referred to herein as “the Threat to Speech article”), which addressed these two theories, and argued that the current evolution of cyber bullying legislation simply goes too far. For example, Hayward states Anti-cyber bullying laws are the greatest threat to student speech because they seek to censor it anytime it occurs, using “substantial disruption” of school activities as justification and often based only on mere suspicion of potential disruption. The Threat to Speech article advocates greater protection of student speech. While we recognize that any regulation of speech by the state may raise First Amendment concerns, we are not so quick to conclude that cyber bullying regulations “chill student free speech.” Our analysis of the law leads us to the conclusion that school administrators have relatively broad discretion to regulate student speech, provided those regulations either serve legitimate pedagogical ends or protect the rights of other students and the school environment. Indeed, as we will demonstrate below, the evolution of the Supreme Court’s student free speech jurisprudence has followed the trend of granting more and more leeway to administrators. Contrary to the claims in the Threat to Speech article, in our opinion that leeway clearly extends to allowing regulation of speech which originates off campus but has a reasonable likelihood of making its way on campus. We also believe that, in addition to true threats and the Tinker substantial disruption standard described in the Threat to Speech article, school administrators may also regulate student speech consistent with the Court’s holding in Fraser—which set what we refer to as the “fundamental values standard” —and based on the fighting words doctrine

A genetically engineered thermally responsive sustained release curcumin depot to treat neuroinflammation.

Radiculopathy, a painful neuroinflammation that can accompany intervertebral disc herniation, is associated with locally increased levels of the pro-inflammatory cytokine tumor necrosis factor alpha (TNFα). Systemic administration of TNF antagonists for radiculopathy in the clinic has shown mixed results, and there is growing interest in the local delivery of anti-inflammatory drugs to treat this pathology as well as similar inflammatory events of peripheral nerve injury. Curcumin, a known antagonist of TNFα in multiple cell types and tissues, was chemically modified and conjugated to a thermally responsive elastin-like polypeptide (ELP) to create an injectable depot for sustained, local delivery of curcumin to treat neuroinflammation. ELPs are biopolymers capable of thermally-triggered in situ depot formation that have been successfully employed as drug carriers and biomaterials in several applications. ELP-curcumin conjugates were shown to display high drug loading, rapidly release curcumin in vitro via degradable carbamate bonds, and retain in vitro bioactivity against TNFα-induced cytotoxicity and monocyte activation with IC50 only two-fold higher than curcumin. When injected proximal to the sciatic nerve in mice via intramuscular (i.m.) injection, ELP-curcumin conjugates underwent a thermally triggered soluble-insoluble phase transition, leading to in situ formation of a depot that released curcumin over 4days post-injection and decreased plasma AUC 7-fold

Does Seed Sanitization Affect the Plant Rhizosphere Microbiome and Its Ability to Compete with the Human Associated Pathogen, E. coli on Salad Crops?

Cultivation of crops in controlled environmental agricultural systems may limit microbial colonization and reduce diversity of the microbial communities. Practices like seed and growth medium sanitization may further impact microbial communities in the mature plant and the plants capacity to limit the growth of pathogens through competition. As humans expand their travels to space, understanding plant growth, health, and development in closed environments will be critical to the success of producing a safe, supplemental food source for astronauts. To determine the persistence of a potential human pathogen in plant growth and development, sanitized and unsanitized seeds from, mizuna (Brassica rapa var japonica) and red romaine lettuce (Lactuca sativa cultivar Outredgeous), were inoculated with Escherichia coli, ATCC 21445, germinated under simulated International Space Station (ISS) environmental conditions and harvested every 7 days until maturity. The persistence of E. coli in the rhizosphere was determined by plating on selective media, real time PCR (Polymerase Chain Reaction) and community sequencing of the rhizosphere communities. E. coli was detected in the crops roots and leaves for several weeks post germination. At day 28, plants from sanitized seeds had significantly higher counts of E. coli on the roots than those from unsanitized seeds. E. coli was also detected on a few uninoculated plants indicating airborne cross contamination among plants in the same growth chamber and suggesting an influence of the natural microbiome on human pathogen survival and persistence in leafy greens. Sequencing analysis revealed variations in composition and diversity between the communities. Understanding the microbial community of the rhizospheric microbiome is only the first step in determining the relationships between plants. Additional studies to include genotypic and phenotypic variations in the plants should be considered to determine if the natural microbes in the rhizosphere may contribute to the health and therefore, safety of the edible plants