8,888 research outputs found
Another factor to consider in choosing a child support guideline: Errors in child support calculations
In an effort to standardize the calculation of monthly child support awards, the federal government requires states to use preestablished formulas to determine the amount of awards. However, because of human error, differences in the experience and training of the officials making the calculations, and the extent to which computers are used to calculate the awards, the formulas do not always yield the same result. In fact, the discrepancy between the amount calculated by an individual child support official and the approved amount as calculated by the state in which that official works can be quite large, on the order of several hundred dollars. Adopting simpler formulas will reduce errors; this should be a priority even if child support officials use computers to calculate award amounts (computers can reduce errors but will not eliminate them, particularly in the case of complex formulas). Efforts to further the training and education of personnel who calculate awards would also help, and child support offices should revise their formulas to cover high-income cases.
Letter to the editor: Further thoughts on: Julie’s museum: the evolution of thinking, dreaming and historicization in the treatment of traumatized patients
Alien Registration- Good, P Glenn (Wade, Aroostook County)
https://digitalmaine.com/alien_docs/32532/thumbnail.jp
Refinements in the use of equivalent latitude for assimilating sporadic inhomogeneous stratospheric tracer observations, 2: Precise altitude-resolved information about transport of Pinatubo aerosol to very high latitude
International audienceFrom high latitude lidar observations, quite precise information is extracted about the temporal evolution and vertical distribution of volcanic aerosol in the high latitude lower stratosphere following the eruption of Mount Pinatubo. Irreversible mixing of lower stratospheric aerosol, to the arctic pole during early 1992, is demonstrated, as a function of potential temperature and time. This work complements previous studies, which either identify vortex intrusions - without demonstrating irreversible transport, or use lower resolution satellite observations. The observed transport is associated tentatively with the vortex disturbance during late January, 1992. A very large number of high resolution lidar observations of Mount Pinatubo aerosol are analysed, without any data averaging. Averaging in measurement or analysis can cause tracer mixing to be overestimated. Averaging in the analysis can also require assumptions about which quantity has the dominant error (in this case, the equivalent latitude coordinate or the measurement), and which part of the data contains real structure. The method below attempts to avoid such assumptions
Response to Teladorsagia circumcincta infection in Scottish Blackface lambs with divergent phenotypes for nematode resistance
peer-reviewedThe objective of this study was to identify Scottish Blackface lambs that were at the extremes of the spectrum of resistance to gastrointestinal nematodes and characterise their response to an experimental nematode challenge. Lambs (n = 90) were monitored for faecal egg count (FEC) (2 samples from each of 2 independent natural infections). The most resistant (n = 10) and susceptible (n = 10) individuals were selected and challenged with 30,000 Teladorsagia circumcincta larvae (L3) at 9 months of age. Response to infection was monitored by measuring FEC, plasma pepsinogen, serum antibodies against nematode larval antigens and haematology profile, until necropsy at 71 days post infection. Worm burden, worm fecundity and the level of anti-nematode antibodies in abomasal mucosa were determined at necropsy.
FEC was consistently higher in susceptible animals (P < 0.05), validating the selection method. Worm fecundity was significantly reduced in resistant animals (P = 0.03). There was also a significant correlation (r = 0.88; P < 0.001) between the number of adult worms and FEC at slaughter. There was no effect of phenotype (resistance/susceptibility) on plasma pepsinogen or on haematology profile. Phenotype had a significant effect on the level of anti-nematode IgA antibodies in serum (P < 0.01), reflecting a higher peak in resistant animals at day 7 post infection.
It is concluded that significant variation in the response to gastrointestinal nematode challenge exists within the Scottish Blackface population with resistant animals displaying significantly lower FEC, lower worm fecundity and higher concentration of anti-nematode IgA antibodies in serum.Kathryn McRae was supported by a Teagasc Walsh fellowship and the Allan and Grace Kay Overseas Scholarship
Exploring uncertainty of Amazon dieback in a perturbed parameter Earth system ensemble
This is the author accepted manuscript. The final version is available from Wiley via the DOI in this recordThe future of the Amazon rainforest is unknown due to uncertainties in projected climate change and the response of the forest to this change (forest resiliency). Here, we explore the effect of some uncertainties in climate and land surface processes on the future of the forest, using a perturbed physics ensemble of HadCM3C. This is the first time Amazon forest changes are presented using an ensemble exploring both land vegetation processes and physical climate feedbacks in a fully coupled modelling framework. Under three different emissions scenarios, we measure the change in the forest coverage by the end of the 21st century (the transient response) and make a novel adaptation to a previously used method known as "dry-season resilience" to predict the long-term committed response of the forest, should the state of the climate remain constant past 2100. Our analysis of this ensemble suggests that there will be a high chance of greater forest loss on longer timescales than is realized by 2100, especially for mid-range and low emissions scenarios. In both the transient and predicted committed responses, there is an increasing uncertainty in the outcome of the forest as the strength of the emissions scenarios increases. It is important to note however, that very few of the simulations produce future forest loss of the magnitude previously shown under the standard model configuration. We find that low optimum temperatures for photosynthesis and a high minimum leaf area index needed for the forest to compete for space appear to be precursors for dieback. We then decompose the uncertainty into that associated with future climate change and that associated with forest resiliency, finding that it is important to reduce the uncertainty in both of these if we are to better determine the Amazon's outcome.Chris Boulton was supported by a PhD studentship provided by the University of Exeter. The contributions to this work from Ben Booth and Peter Good were supported by the Joint UK DECC/Defra Met Office Hadley Centre Climate Programme (GA01101)
Patterns of local and nonlocal water resource use across the western U.S. determined via stable isotope intercomparisons
pre-printIn the western U.S., the mismatch between public water demands and natural water availability necessitates large interbasin transfers of water as well as groundwater mining of fossil aquifers. Here we identify probable situations of nonlocal water use in both space and time based on isotopic comparisons between tap waters and potential water resources within hydrologic basins. Our approach, which considers evaporative enrichment of heavy isotopes during storage and distribution, is used to determine the likeli-hood of local origin for 612 tap water samples collected from across the western U.S. We find that 64% of samples are isotopically distinct from precipitation falling within the local hydrologic basin, a proxy for groundwater with modern recharge, and 31% of samples are isotopically distinct from estimated surface water found within the local basin. Those samples inconsistent with local water sources, which we suggest are likely derived from water imported from other basins or extracted from fossil aquifers, are primarily clus- tered in southern California, the San Francisco Bay area, and central Arizona. Our isotope-based estimates of nonlocal water use are correlated with both hydrogeomorphic and socioeconomic properties of basins, suggesting that these factors exert a predictable influence on the likelihood that nonlocal waters are used to supply tap water. We use these basin properties to develop a regional model of nonlocal water resource use that predicts (r2=0.64) isotopically inferred patterns and allows assessment of total interbasin transfer and/or fossil aquifer extraction volumes across the western U.S
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The inconstancy of the transient climate response parameter under increasing COâ‚‚
In the Coupled Model Intercomparison Project Phase 5 (CMIP5), the model-mean increase in global mean surface air temperature T under the 1pctCO2 scenario (atmospheric CO2 increasing at 1% yr−1) during the second doubling of CO2 is 40% larger than the transient climate response (TCR), i.e. the increase in T during the first doubling. We identify four possible contributory effects. First, the surface climate system loses heat less readily into the ocean beneath as the latter warms. The model spread in the thermal coupling between the upper and deep ocean largely explains the model spread in ocean heat uptake efficiency. Second, CO2 radiative forcing may rise more rapidly than logarithmically with CO2 concentration. Third, the climate feedback parameter may decline as the CO2 concentration rises. With CMIP5 data, we cannot distinguish the second and third possibilities. Fourth, the climate feedback parameter declines as time passes or T rises; in 1pctCO2, this effect is less important than the others. We find that T projected for the end of the twenty-first century correlates more highly with T at the time of quadrupled CO2 in 1pctCO2 than with the TCR, and we suggest that the TCR may be underestimated from observed climate change
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Proliferation tracing with single-cell mass cytometry optimizes generation of stem cell memory-like T cells.
Selective differentiation of naive T cells into multipotent T cells is of great interest clinically for the generation of cell-based cancer immunotherapies. Cellular differentiation depends crucially on division state and time. Here we adapt a dye dilution assay for tracking cell proliferative history through mass cytometry and uncouple division, time and regulatory protein expression in single naive human T cells during their activation and expansion in a complex ex vivo milieu. Using 23 markers, we defined groups of proteins controlled predominantly by division state or time and found that undivided cells account for the majority of phenotypic diversity. We next built a map of cell state changes during naive T-cell expansion. By examining cell signaling on this map, we rationally selected ibrutinib, a BTK and ITK inhibitor, and administered it before T cell activation to direct differentiation toward a T stem cell memory (TSCM)-like phenotype. This method for tracing cell fate across division states and time can be broadly applied for directing cellular differentiation
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