Propuesta de elaboracion de un plan de medidas sustitutivas al plan de seguridad e higiene ocupacional, para la farmacia popular #1 en la calle libertad, y la sucursal #2 ubicada en la 25 calle poniente, en la ciudad de Santa Ana

La Ley General de Prevención de Riesgos en los Lugares de Trabajo, establece, en su artículo 8, la responsabilidad de las empresas de elaborar y ejecutar El Programa de Gestión de Prevención de Riesgos Ocupacionales, buscando garantizar la seguridad y salud de sus trabajadores y trabajadoras que laboran en ella; sin embargo, cuando la empresa cuenta con menos de quince trabajadore

Neonatal hearing screening in high-risk patients with otoacoustic emissions: evaluation of results

Resumen Objetivo: evaluar la efectividad del programa de tamizaje auditivo del Homic en pacientes de alto riesgo de hipoacusia neurosensorial, el cual está basado en la realización de otoemisiones acústicas Diseño: estudio de cohorte retrospectiva, en el que se incluirán a los pacientes mayores de 12 meses de edad nacidos en el Hospital Militar central (HMC) entre enero de 2009 y diciembre de 2012; a quienes por condiciones de alto riesgo de hipoacusia neurosensorial se les realizó antes de los 6 meses de edad otoemisiones acústicas como prueba de tamizaje auditivo. A esta población, se le realizara diagnostico auditivo por medio del método diagnostico Gold Standart el cual es el “cross cheking”. Resultados: Se estudiaron los factores de riesgo para hipoacusia neurosensorial encontrando que el peso al nacer ≤1500 gr. Se relacionó con hipoacusia en un 16%. El 5.6% tiene antecedente familiar de hipoacusia neurosensorial en primer y segundo grado de consanguinidad. La infección congénita (TORCHS: toxoplasmosis, sífilis, rubéola, citomegalovirus, o herpes) como factor de riesgo se presentó en el 2.4% únicamente con la presencia de Toxoplasmosis, de los cuales 2 oídos presentaron cofosis. Conclusiones: La sensibilidad de las Otoemisiones acusticas para sospechar hipoacusia neurosensorial fue del 82.5%. La especificidad estimada en nuestro estudio fue de 90.9%Hospital Militar CentralObjective: To evaluate the effectiveness of auditory screening program Central Military Hospital in patients at high risk of sensorineural hearing loss, which is based on the realization of otoacoustic emissions. Design: Retrospective cohort study, in which over 12 months of age born patients in the Central Military Hospital (HOMIC) between January 2009 and December 2012 were included; who by conditions of high risk of sensorineural hearing loss was performed before 6 months of age otoacoustic emissions and hearing screening test. Total population was 125 patients. We evaluated each ear separately for a total of 250 measurements, this population was conducted auditory diagnosis through cross cheking diagnosis method were analyzed. Results: Risk factors for sensorineural hearing loss were studied. We found that birth weight ≤1500 g. It was associated with hearing loss by 16%. 5.6% have a family history of sensorineural hearing loss in first and second degree of consanguinity. Congenital infection (TORCHS: toxoplasmosis, syphilis, rubella, cytomegalovirus, or herpes) as a risk factor occurred in 2.4% only in the presence of Toxoplasmosis, of which 2 ears presented deafness. Conclusions: The otoacoustic emissions are effective as hearing screening test in Military Central Hospital in patients at high risk of Sensorineural hearing loss. The sensitivity of otoacoustic emissions to suspect sensorineural hearing loss was 82.5%. The estimated specificity in our study was 90.9

Itinerario de enseñanza sobre la magnitud longitud: ¡Este robot está en apuros!

En el siguiente Trabajo de Fin de Grado (TFG en adelante) se presenta el diseño de un itinerario didáctico para la construcción del concepto de magnitud longitud y su medida, destinado al alumnado de 6º curso de Educación Infantil (5-6 años). Para estructurar de una manera sólida este trabajo, se realiza una revisión teórica sobre diferentes aspectos relacionados con el trabajo como son, el enfoque de los itinerarios didácticos, la enseñanza de la magnitud longitud, los beneficios del uso de materiales manipulativos, la pizarra digital interactiva (PDI) y la robótica educativa. El itinerario didáctico diseñado consta de un conjunto de actividades entrelazadas que abarcan los contextos informales, intermedios y formales necesarios para adquirir un adecuado aprendizaje matemático.In the following Final Degree Project (FDP onwards) we present a design of a didactic itinerary for the construction of the concept of length and its measurement for the sixth year of Early Childhood Education (5-6 years). To structure this FDP in a solid way, a theoretical review is made on different aspects related to the FDP such as the didactic itineraries approach, the teaching of the length, the benefits of using manipulative materials, Interactive Whiteboard and educational robotics. The didactic itinerary designed consists of some intertwined activities that cover informal, intermediate and formal contexts needed to acquire an appropriate mathematical learning

SARS-CoV-2 Neutralizing Antibodies in Mexican Population: A Five Vaccine Comparison

Neutralizing antibodies (NAs) are key immunological markers and are part of the humoral response of the adaptive immune system. NA assays determine the presence of functional antibodies to prevent SARS-CoV-2 infection. We performed a real-world evidence study to detect NAs that confer protection against SARS-CoV-2 after the application of five vaccines (Pfizer/BioNTech, AstraZeneca, Sinovac, Moderna, and CanSino) in the Mexican population. Side effects of COVID-19 vaccines and clinical and demographic factors associated with low immunogenicity were also evaluated. A total of 242 SARS-CoV-2-vaccinated subjects were recruited. Pfizer/BioNTech and Moderna proved the highest percentage of inhibition in a mono-vaccine scheme. Muscular pain, headache, and fatigue were the most common adverse events. None of the patients reported severe adverse events. We found an estimated contagion-free time of 207 (IQR: 182–231) and 187 (IQR: 184–189) days for Pfizer/BioNTech and CanSino in 12 cases in each group. On the basis of our results, we consider that the emerging vaccination strategy in Mexico is effective and safe

SETD2 transcriptional control of ATG14L/S isoforms regulates autophagosome-lysosome fusion

Macroautophagy/autophagy is an evolutionarily conserved and tightly regulated catabolic process involved in the maintenance of cellular homeostasis whose dysregulation is implicated in several pathological processes. Autophagy begins with the formation of phagophores that engulf cytoplasmic cargo and mature into double-membrane autophagosomes; the latter fuse with lysosomes/vacuoles for cargo degradation and recycling. Here, we report that yeast Set2, a histone lysine methyltransferase, and its mammalian homolog, SETD2, both act as positive transcriptional regulators of autophagy. However, whereas Set2 regulates the expression of several autophagy-related (Atg) genes upon nitrogen starvation, SETD2 effects in mammals were found to be more restricted. In fact, SETD2 appears to primarily regulate the differential expression of protein isoforms encoded by the ATG14 gene. SETD2 promotes the expression of a long ATG14 isoform, ATG14L, that contains an N-terminal cysteine repeats domain, essential for the efficient fusion of the autophagosome with the lysosome, that is absent in the short ATG14 isoform, ATG14S. Accordingly, SETD2 loss of function decreases autophagic flux, as well as the turnover of aggregation-prone proteins such as mutant HTT (huntingtin) leading to increased cellular toxicity. Hence, our findings bring evidence to the emerging concept that the production of autophagy-related protein isoforms can differentially affect core autophagy machinery bringing an additional level of complexity to the regulation of this biological process in more complex organisms.Peer reviewe

En síntesis, dar cuenta del resumen

Los estudiantes de la Especialización en Procesos lecto-escriturales, de la Corporación Universitaria Minuto de Dios, realizaron un trabajo de investigación entre docentes de diferentes niveles de formación y desempeño laboral, relacionado con el resumen como tipología textual, su reconocimiento y manejo como herramienta para mejorar las habilidades de análisis, interpretación y producción textual, con el objetivo de diseñar una estrategia didáctica que permita fortalecer y cualificar las competencias escriturales de los docentes a partir del resumen

En síntesis, dar cuenta del resumen

Los estudiantes de la Especialización en Procesos lecto-escriturales, de la Corporación Universitaria Minuto de Dios, realizaron un trabajo de investigación entre docentes de diferentes niveles de formación y desempeño laboral, relacionado con el resumen como tipología textual, su reconocimiento y manejo como herramienta para mejorar las habilidades de análisis, interpretación y producción textual, con el objetivo de diseñar una estrategia didáctica que permita fortalecer y cualificar las competencias escriturales de los docentes a partir del resumen

Use of Non-Steroidal Anti-Inflammatory Drugs That Elevate Cardiovascular Risk: An Examination of Sales and Essential Medicines Lists in Low-, Middle-, and High-Income Countries

PMCID: PMC3570554This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Nephrotic syndrome secondary to membranoproliferative glomerulonephritis due to Sjögren’s syndrome

El síndrome de Sjögren (SS), enfermedad autoinmune crónica, primaria o secundaria a otros desórdenes inmunológicos. La prevalencia es 0.05-0.23%, relación hombre: mujer 1:9, grupo etáreo 52-72 años. La afectación renal en el SSP (primario) puede ocasionar compromiso glomerular y/o tubular. Reportamos el caso de un hombre de 56 años, previamente sano que presentó síndrome nefrótico en el contexto de una glomerulonefritis membranoproliferativa (GMNMP), se diagnosticó SS con compromiso glomerular y se realizó revisión de la literatura.Presentación de casos136-139Sjögren’s syndrome (SS) is a chronic autoimmune disease primary or secondary to other immunological disorders. The prevalence is 0.05-0.23%, male:female ratio 1:9, age group 52-72 years. Renal involvement in primary SS can lead to glomerular and/or tubular involvement. The case of a 56-year-old man previously healthy that presented nephrotic syndrome in the context of a membranoproliferative glomerulonephritis (MPGN) and was diagnosed with SS with glomerular involvement is reported, and a literature review was performed

Community of Practice of Promotoras de Salud to address health inequities during and beyond the COVID-19 pandemic

Using principles of Community-Based Participatory Research, we describe a community of practice for community health workers and promotoras (CHW/Ps) to address COVID-19 inequities in the Latinx community. We offer a concrete example of how programs can engage CHW/Ps as full partners in the research process, and how programs can support CHW/Ps’ capacity and workforce development during implementation. We conducted four focus groups with CHW/Ps (n = 31) to understand needs and invited 15 participants to the community of practice to work on issues identified by the group. We examined impact according to number of community members reached, types of outreach activities, surveys, and online views of educational materials. Process evaluation involved two focus groups with seven organizations and a Ripple Effects Mapping session with the CHW/Ps. Our community of practice has built CHW/Ps’ capacity via 31 workshop and co-created culturally and linguistically relevant COVID-19 materials that have reached over 40,000 community members and over 3 million people online. The community of practice proved effective in supporting CHW/Ps to address COVID-19 inequities in the Latinx community. Our evaluations demonstrated benefits for community-academic partnerships, for CHW/Ps, and for the community. This model represents an innovative workforce training model to address health inequities and can be applied to other health topics