Optical measurements of phase steps in segmented mirrors - fundamental precision limits

Phase steps are an important type of wavefront aberrations generated by large telescopes with segmented mirrors. In a closed-loop correction cycle these phase steps have to be measured with the highest possible precision using natural reference stars, that is with a small number of photons. In this paper the classical Fisher information of statistics is used for calculating the Cramer-Rao bound, which determines the limit to the precision with which the height of the steps can be estimated in an unbiased fashion with a given number of photons and a given measuring device. Four types of measurement devices are discussed: a Shack-Hartmann sensor with one small cylindrical lenslet covering a sub-aperture centred over a border, a modified Mach-Zehnder interferometer, a Foucault test, and a curvature sensor. The Cramer-Rao bound is calculated for all sensors under ideal conditions, that is narrowband measurements without additional noise or disturbances apart from the photon shot noise. This limit is compared with the ultimate quantum statistical limit for the estimate of such a step which is independent of the measuring device. For the Shack-Hartmann sensor, the effects on the Cramer-Rao bound of broadband measurements, finite sampling, and disturbances such as atmospheric seeing and detector readout noise are also investigated. The methods presented here can be used to compare the precision limits of various devices for measuring phase steps and for optimising the parameters of the devices. Under ideal conditions the Shack-Hartmann and the Foucault devices nearly attain the ultimate quantum statistical limits, whereas the Mach-Zehnder and the curvature devices each require approximately twenty times as many photons in order to reach the same precision.Comment: 23 pages, 19 figures, to be submitted to Journal of Modern Optic

A next-generation liquid xenon observatory for dark matter and neutrino physics

The nature of dark matter and properties of neutrinos are among the most pressing issues in contemporary particle physics. The dual-phase xenon time-projection chamber is the leading technology to cover the available parameter space for weakly interacting massive particles, while featuring extensive sensitivity to many alternative dark matter candidates. These detectors can also study neutrinos through neutrinoless double-beta decay and through a variety of astrophysical sources. A next-generation xenon-based detector will therefore be a true multi-purpose observatory to significantly advance particle physics, nuclear physics, astrophysics, solar physics, and cosmology. This review article presents the science cases for such a detector

Cardiomiectomia com fundoplicatura parcial videolaparoscópica no tratamento do megaesôfago não avançado: estudo de 50 casos

Foram estudados prospectivamente cinqüenta pacientes com megaesôfago não avançado tratados por cardiomiectomia com fundoplicatura parcial por via laparoscópica, avaliados sob o ponto de vista clínico e funcional. Houve 12% de complicações intra-operatórias, duas complicações pós-operatórias imediatas e um óbito. Não houve conversões ou complicações tardias. Os resultados ótimos e bons somaram 97,9% dos casos. Houve tendência à diminuição radiológica do calibre do esôfago e desaparecimento da esofagite à endoscopia. A eletromanometria mostrou diminuição significativa da pressão média do esfíncter inferior do esôfago após a operação; a pHmetria de 24 horas constatou diminuição da estase esofágica e ausência de refluxo gastro-esofágico no pós-operatório. Não houve diferença entre os resultados do tratamento de pacientes com megaesôfago chagásico e não chagásico. Os pacientes tiveram o benefício da cirurgia laparoscópica de menor dor, rápida realimentação, alta precoce e breve retorno às atividades habituais

Mobilizing Community Health Workers to Address Mental Health Disparities for Underserved Populations: A Systematic Review

This systematic review evaluates efforts to date to involve community health workers (CHWs) in delivering evidence-based mental health interventions to underserved communities in the United States and in low- and middle-income countries. Forty-three articles (39 trials) were reviewed to characterize the background characteristics of CHW, their role in intervention delivery, the types of interventions they delivered, and the implementation supports they received. The majority of trials found that CHW-delivered interventions led to symptom reduction. Training CHWs to support the delivery of evidence-based practices may help to address mental health disparities. Areas for future research as well as clinical and policy implications are discussed