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Rhegmatogenous retinal detachment masquerading as exudative panuveitis with intense anterior chamber inflammatory reaction.
Purpose:This is a retrospective case report illustrating the diagnostic and therapeutic challenges associated with a chronic rhegmatogenous retinal detachment masquerading as a severe panuveitis with intense anterior chamber inflammation. We have included clinical features, anterior segment and fundus photography, B-scan ultrasonography, fluorescein angiography, and intraoperative findings. Observations:A 26-year-old male presented with features of unilateral panuveitis: hypotony, anterior segment inflammation (posterior synechiae and anterior chamber cell with fibrin clumping), diffuse choroidal thickening, and retinal detachment. Laboratory investigations for infectious or rheumatologic processes were negative, and empiric systemic corticosteroid therapy was unsuccessful. This prompted suspicion for an alternate primary etiology, and pars plana vitrectomy revealed small retinal breaks as the underlying cause of the retinal detachment and inflammation. Conclusions:Rhegmatogenous retinal detachments are a known cause of intraocular inflammation. Nevertheless, it remains a challenge to recognize retinal breaks in this setting, particularly with robust anterior segment inflammation and posterior findings resembling severe exudative uveitis. Being aware of this unique presentation may prevent delays in diagnosis and have important prognostic implications
Rhodium complexes bearing tetradentate diamine-bis(phenolate) ligands
Using tetradentate, dianionic ligands, several new rhodium complexes have been prepared. Some of these diamine-bis(phenolate) compounds, are active for CâH activation of benzene. These complexes are air and thermally stable. All four complexes were characterized by X-ray diffraction
Genome-wide association study in two cohorts from a multi-generational mouse advanced intercross line highlights the difficulty of replication due to study-specific heterogeneity
There has been extensive discussion of the Replication Crisis in many fields, including genome-wide association studies
Lattice energy-momentum tensor with Symanzik improved actions
We define the energy-momentum tensor on lattice for the and
for the nonlinear -model Symanzik tree-improved actions, using Ward
identities or an explicit matching procedure. The resulting operators give the
correct one loop scale anomaly, and in the case of the sigma model they can
have applications in Monte Carlo simulations.Comment: Self extracting archive fil
Hydration of Na+, Ni2+, and Sm3+ in the Interlayer of Hectorite: A Quasielastic Neutron Scattering Study
International audienceQuasielastic neutron scattering experiments were performed with Naâhectorite, Niâhectorite, and Smâhectorite samples in order to find out whether Sm3+ is present in the clay interlayer as a fully hydrated cation (outer-sphere complex), or, as it follows from neutron diffraction data analysis, it is dehydrated and bound to the clay surface (inner-sphere complex). The results obtained for the Smâhectorite were compared with other interlayer cations: strongly hydrated Ni2+ and relatively weakly hydrated Na+. It was found that water mobility in the Smâhectorite sample is very close to the water mobility in Niâhectorite. This is only possible if the Sm3+ ion is fully hydrated. It was shown that water molecules hydrating Ni2+ and Sm3+ exhibit diffusion mobility measurable with backscattering spectrometers. The diffusion coefficients of the exchangeable cations were found using the slow exchange approximations DNi = (0.05 â 0.14) Ă 10â9 m2/s and DSm = (0.04 â 0.18) Ă 10â9 m2/s
Chaplygin gas with non-adiabatic pressure perturbations
Perturbations in a Chaplygin gas, characterized by an equation of state , may acquire non-adiabatic contributions if spatial variations of the
parameter are admitted. This feature is shown to be related to a specific
internal structure of the Chaplygin gas. We investigate how perturbations of
this type modify the adiabatic sound speed and influence the time dependence of
the gravitational potential which gives rise to the Integrated Sachs-Wolfe
effect in the anisotropy spectrum of the cosmic microwave background.Comment: 16 pages, comments and references added, accepted for publication in
Class.Quantum Gra
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A double masked randomised 4-week, placebo-controlled study in the USA, Thailand and Taiwan to compare the efficacy of oral valganciclovir and topical 2% ganciclovir in the treatment of cytomegalovirus anterior uveitis: study protocol.
IntroductionCytomegalovirus (CMV) anterior uveitis is a recognised cause of anterior uveitis in immunocompetent patients and is preventable cause of vision loss. Ocular sequelae include corneal endothelial damage which can cause corneal oedema and failure, as well as glaucoma. Recurrences of inflammation are common and therefore patients are often exposed to long-term therapy. Oral therapy is available in the form of valganciclovir, although with the caveat of systemic side effects such as bone marrow suppression and renal failure necessitating regular interval laboratory monitoring. Recent reports have demonstrated that topical 2% ganciclovir solution may offer promising treatment outcomes in patients with CMV anterior uveitis with superior safety, cost-effectiveness and convenience profiles. An investigation into the relative equipoise of these therapies is warranted for these reasons.Methods and analysisThe Systemic and Topical Control of Cytomegalovirus Anterior uveitis: Treatment Outcomes (STACCATO) trial is designed as a multicentre, block randomised by site, double-masked, placebo-controlled trial comparing the efficacy of oral valganciclovir, 2% topical ganciclovir and placebo in treating PCR-proven CMV anterior uveitis. Participant clinical evaluation will occur at three study time points by a masked study ophthalmologist over a 28-day period to assess resolution of ocular inflammation (secondary outcome). A control group will provide additional information about the possible impact that the infected host's immune response may play in controlling local viral replication. The primary analysis is an analysis of covariance (three arms) correcting for baseline to compare quantitative CMV viral load in the anterior chamber (AC) aqueous fluid before and 7âdays after treatment.Ethics and disseminationThe University of California San Francisco Committee on Human Research and the Khon Kaen University Institutional Review Board have given ethical approval. The results of this trial will be presented at local and international meetings and submitted for peer-reviewed journals for publication.Trial registration numberNCT03576898
The IGEX experiment revisited: a response to the critique of Klapdor-Kleingrothaus,Dietz, and Krivosheina
This paper is a response to the article "Critical View to" the IGEX
neutrinoless double-beta decay experiment..."published in Phys. Rev.D, Volume
65 (2002) 092007," by H.V.Klapdor-Kleingrothaus, A. Dietz, and I.V.Krivosheina,
published as preprint hep-ph/0403056. The criticisms are confronted, and the
questions raised are answered. We demonstrate that the lower limit quoted by
IGEX, for the half life of Ge-76 neutrinoless double beta decay, 1.57x10**25 y,
is correct and that there was no "arithmetical error"-as claimed in the "
Critical Review" article
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