New avenues for integrating information literacy into the curriculum

A generally understood mission of library instruction programs is to promote information literacy (IL) and critical thinking across the curriculum. The majority of programmatic IL collaborations with higher education core curricula are found in introductory composition or communication courses. Other more unconventional avenues offer potentially more effective ways to teach students the basic IL concepts and skills. At the University of Nevada, Las Vegas (UNLV), conversations with College of Education faculty helped librarians identify a strategic and unique point of entry for IL instruction. Using the ADDIE model as a conceptual framework, librarians and an instructional designer met with the course coordinators for the Valuing Cultural Diversity course to collaboratively develop tools and assignments that deconstruct and scaffold the research process for students. The systematic approach for identifying this course, developing the partnership, creating the assessment tools, and refining instruction and assignments based on our findings will be discussed

Genome-wide association study in two cohorts from a multi-generational mouse advanced intercross line highlights the difficulty of replication due to study-specific heterogeneity

There has been extensive discussion of the Replication Crisis in many fields, including genome-wide association studies

Some aspects of the iodine metabolism of the giant kelp Macrocystis pyrifera (phaeophyceae)

We are grateful to the Total Foundation (Paris) and to the MASTS pooling initiative (Marine Alliance for Science and Technology for Scotland, funded by the Scottish Funding Council and contributing institutions; grant reference HR09011), both for their funding support to FCK. We thank Prof. Matt Edwards (SDSU department of Biology) and his students for help in collecting specimens and for the use of equipment.Peer reviewedPostprin

Ice Dragon: A Mission to Address Science and Human Exploration Objectives on Mars

We present a mission concept where a SpaceX Dragon capsule lands a payload on Mars that samples ground ice to search for evidence of life, assess hazards to future human missions, and demonstrate use of Martian resources

Quantitative measurements and modeling of cargo–motor interactions during fast transport in the living axon

Author Posting. © IOP Publishing, 2012. This article is posted here by permission of IOP Publishing for personal use, not for redistribution. The definitive version was published in Physical Biology 9 (2012): 055005, doi:10.1088/1478-3975/9/5/055005.The kinesins have long been known to drive microtubule-based transport of sub-cellular components, yet the mechanisms of their attachment to cargo remain a mystery. Several different cargo-receptors have been proposed based on their in vitro binding affinities to kinesin-1. Only two of these—phosphatidyl inositol, a negatively charged lipid, and the carboxyl terminus of the amyloid precursor protein (APP-C), a trans-membrane protein—have been reported to mediate motility in living systems. A major question is how these many different cargo, receptors and motors interact to produce the complex choreography of vesicular transport within living cells. Here we describe an experimental assay that identifies cargo–motor receptors by their ability to recruit active motors and drive transport of exogenous cargo towards the synapse in living axons. Cargo is engineered by derivatizing the surface of polystyrene fluorescent nanospheres (100 nm diameter) with charged residues or with synthetic peptides derived from candidate motor receptor proteins, all designed to display a terminal COOH group. After injection into the squid giant axon, particle movements are imaged by laser-scanning confocal time-lapse microscopy. In this report we compare the motility of negatively charged beads with APP-C beads in the presence of glycine-conjugated non-motile beads using new strategies to measure bead movements. The ensuing quantitative analysis of time-lapse digital sequences reveals detailed information about bead movements: instantaneous and maximum velocities, run lengths, pause frequencies and pause durations. These measurements provide parameters for a mathematical model that predicts the spatiotemporal evolution of distribution of the two different types of bead cargo in the axon. The results reveal that negatively charged beads differ from APP-C beads in velocity and dispersion, and predict that at long time points APP-C will achieve greater progress towards the presynaptic terminal. The significance of this data and accompanying model pertains to the role transport plays in neuronal function, connectivity, and survival, and has implications in the pathogenesis of neurological disorders, such as Alzheimer's, Huntington and Parkinson's diseases.This work was supported in part by NINDS RO1 NS046810 and RO1 NS062184 (ELB), NIGMS RO1 GM47368 (ELB), the Physical Sciences in Oncology Center grant U54CA143837 (VC), NIGMS K12GM088021 (JP), and NSF IGERT DGE-0549500 (PES). ELB and VC also received pilot project funds from the UNM Center for Spatiotemporal modeling, funded by NIGMS, P50GM08273, which also supported AC.2013-09-2

The influence of marine algae on iodine speciation in the coastaocean

Funding Information: This work was supported in part by grant CHE-1664657 from the National Science Foundation to CJC and FCK, the TOTAL Foundation (Paris) and the UK Natural Environment Research Council grants (NE/D521522/1, NE/ J023094/1, Oceans 2025 / WP 4.5) to FCK. We are also grateful for funding from the MASTS pooling initiative (The Marine Alliance for Science and Technology for Scotland). We thank Dr. M. L. Carter, SIO for help with collection of water samples at Scripps Pier, César O. Almeda-Jáuregui, CICESE for Ocean Data View plots and Dr. Avery Tatters, USC for the initial culture of Lingulodinium polyedra. A fellowship from the Hanse-Wissenschaftskolleg to CJC is also gratefully acknowledged.Peer reviewedPublisher PD

The ACE1 Electrical Impedance Tomography System for Thoracic Imaging

The design and performance of the active complex electrode (ACE1) electrical impedance tomography system for single-ended phasic voltage measurements are presented. The design of the hardware and calibration procedures allows for reconstruction of conductivity and permittivity images. Phase measurement is achieved with the ACE1 active electrode circuit which measures the amplitude and phase of the voltage and the applied current at the location at which current is injected into the body. An evaluation of the system performance under typical operating conditions includes details of demodulation and calibration and an in-depth look at insightful metrics, such as signal-to-noise ratio variations during a single current pattern. Static and dynamic images of conductivity and permittivity are presented from ACE1 data collected on tank phantoms and human subjects to illustrate the system\u27s utility

An actionable anti-racism plan for geoscience organizations.

Geoscience organizations shape the discipline. They influence attitudes and expectations, set standards, and provide benefits to their members. Today, racism and discrimination limit the participation of, and promote hostility towards, members of minoritized groups within these critical geoscience spaces. This is particularly harmful for Black, Indigenous, and other people of color in geoscience and is further exacerbated along other axes of marginalization, including disability status and gender identity. Here we present a twenty-point anti-racism plan that organizations can implement to build an inclusive, equitable and accessible geoscience community. Enacting it will combat racism, discrimination, and the harassment of all members