High-Performance low-vcc in-order core

Power density grows in new technology nodes, thus requiring Vcc to scale especially in mobile platforms where energy is critical. This paper presents a novel approach to decrease Vcc while keeping operating frequency high. Our mechanism is referred to as immediate read after write (IRAW) avoidance. We propose an implementation of the mechanism for an Intel® SilverthorneTM in-order core. Furthermore, we show that our mechanism can be adapted dynamically to provide the highest performance and lowest energy-delay product (EDP) at each Vcc level. Results show that IRAW avoidance increases operating frequency by 57% at 500mV and 99% at 400mV with negligible area and power overhead (below 1%), which translates into large speedups (48% at 500mV and 90% at 400mV) and EDP reductions (0.61 EDP at 500mV and 0.33 at 400mV).Peer ReviewedPostprint (published version

Multivariate stability monitoring and shelf life models of deterioration of vegetable oils under real time ageing conditions – Extra virgin olive oil as a main case of study

Modelling quality depletion of oils and establishing their shelf life (or ageing rate) remains a challenge for food industry. A persistent issue in the control of lipid oxidation is deciding which oxidation products are the most suitable to be monitored. Several attempts have been done in this regard, however, the number of parameters that can be considered to assess oil shelf life is excessively wide and the proposed univariate models have proven to be extremely dependent on experimental conditions. For this reason, the methodology for carrying out a multivariate kinetic model is presented, combining physico-chemical and sensory parameters from experimental analytical determinations, and chemometric data processing tools. The main objective is to develop a multivariate shelf life model that allow predicting the number of months in which an extra virgin olive oil complies with the requirements of its commercial category when ageing takes place under standard trading conditionsThe European Regional Development Fund (ERDF)Ministry of Science and Technology within the framework of the funding corresponding to ’Retos- Colaboraci´on’ (Challenges-Collaboration Program) call of the State Program for Research, Development and Innovation Focussed to Challenges of Society [RTC-2017-6170-2].Ministry of Universities for the Training of University Teachers (FPU 19/02078).University of Granada / CBUA

Monitoring the Shelf Life of Refined Vegetable Oils under Market Storage Conditions—A Kinetic Chemofoodmetric Approach

Most physicochemical and sensory properties of edible vegetable oils are not stable over time. One of the main causes of quality depletion of vegetable oils is oxidation, which influences sensory acceptability and nutritional value, and could even lead to toxic compounds. That negative influence affects international refined oil prices and the variety of its culinary applications. Modelling quality depletion of vegetable oils and establishing the shelf life, generally accepted as the time until rancidity becomes evident, already remains a challenge for the industry. Hence, this paper will show a promising chemofoodmetric methodology, as an easy and straightforward tool to estimate the current shelf-life of refined vegetable oils, based on a comprehensive characterisation of quality depletion-related changes over storage time under real market conditions. The methodology for building a multivariate kinetic ageing-based model is described, taking into account all timerelated physicochemical parameters and chemometric processing tools. From a particular ageing state, multiparametric models are able to reliably infer the expected storage time for each vegetable oil so that it remains consistent with acceptability requirements. The results of the study pointed out the accuracy of multivariate shelf-life modelling with regard to univariate modelling. Discrepancies were found in the oxidation rates of oils extracted from different plant seeds.Ministry of Universities for the Training of University Teachers FPU 19/0207

Producción de un videojuego en realidad virtual con seguimiento de movimiento en visor y controladores manuales utilizando metodología Ágil

El presente Trabajo de Fin de Grado aborda la producción de videojuegos en Realidad Virtual desde el punto de vista de las metodologías ágiles en Ingeniería de Software. Analizamos el estado de la técnica en Realidad Virtual comenzando por una breve introducción a su historia, desde sus inicios a mediados del siglo XX hasta la aparición de los modernos cascos de Realidad Virtual en el estado actual de la técnica. Sobre estos últimos detallamos especialmente dos de los dispositivos de alta gama disponibles en el mercado: Oculus Rift y HTC Vive, con el que hemos trabajado. También revisamos entornos de desarrollo y herramientas disponibles, como Unity o Unreal Engine, con el que nos quedamos finalmente para aprovechar su potencia y robusta integración con Vive. El objetivo general de este proyecto es crear una experiencia en primera persona muy inmersiva mediante el uso del visor de Vive, con seguimiento de movimiento, y de los controladores de mano correspondientes, también capaces de hallar su posición y orientación. Estos controladores avanzados nos permiten experimentar con muy diferentes movimientos e interacciones dentro de la Realidad Virtual, de manera que podemos comprobar cuáles de ellos resultan más naturales y satisfactorios para los usuarios, y cuales son más factibles para implementar. Hemos elegido como hilo conductor de la experiencia el género de terror, concretamente la temática de las enfermedades mentales y las fobias, por considerarlo uno de los [que] más emoción puede llegar a provocar entre los jugadores de Realidad Virtual. Con el fin de lograr nuestro objetivo de manera eficiente, tomamos una serie de decisiones por las cuales comenzamos a utilizar la metodología ágil conocida como Scrum para modelar el proceso de desarrollo de nuestro proyecto. El resultado de las distintas fases de planificación, especificación, análisis, diseño, implementación y pruebas, así como la creación de un completo diario de desarrollo generada durante el mismo proporciona una sólida base, un videojuego en Realidad Virtual de nuestra autoría y con la mayoría de las características deseadas. Gracias a esa base podemos obtener unas conclusiones finales y valorar satisfactoriamente tanto los resultados obtenidos como la aplicación de la citada metodología en este proyecto. Consideramos que ahora está mucho más cerca la posibilidad de crear un producto comercial innovador que se apoye en las contribuciones de este trabajo

Innovative non-targeted liquid chromatography fingerprinting approach for authenticating tigernuts under Protected Designation of Origin quality seal

The authors are deeply grateful to the ‘Valencia’ PDO Manage- ment Body for providing the samples for this study. In addition, AMJC acknowledges the grant (RYC2021-031993-I) funded by MCIN/AEI/501100011033 and ‘European Union NextGeneration EU/PRTR’. Funding for open access charge: Universidad de Gra- nada / CBUA.BACKGROUND: Tigernut is a typical foodstuff from a specific region of Valencia (Spain) called ‘L'Horta Nord’, where it is com- mercialized under a Protected Designation of Origin (PDO) as Chufa de Valencia (‘Valencia's tigernut’). PDO-recognized tiger- nuts present unique characteristics associated with their particular production region. Increasing demand and the associated expansion of its cultivation area has made necessary an exhaustive quality control to check the geographical origin and quality seal. RESULTS: In this work, a new multivariate analytical method capable of authenticating the PDO quality seal of tigernut samples was developed. Tigernut fat fraction was extracted under optimal conditions, applying the methodology of design of experi- ments. The analytical method combined fingerprinting methodology and chemometric tools to observe the natural grouping of samples using the exploratory analysis method and to develop classification models (partial least squares–discriminatory analysis; PLS-DA) to discriminate between two sample categories: (i) PDO tigernuts; and (ii) NON-PDO tigernuts. CONCLUSION: The built PLS-DA model demonstrated 100% accuracy, high sensitivity and specificity, revealing that the tigernut fat fraction can be applied to authenticate the PDO quality seal.Grant (RYC2021-031993-I) funded by MCIN/AEI/501100011033 and ‘European Union NextGeneration EU/PRTR’Funding for open access charge: Universidad de Granada / CBU

Triggering the QCD phase transition through the Unruh effect: Chiral symmetry restoration for uniformly accelerated observers.

In this work we study the chiral phase transition as observed by an accelerating observer taking into account the Unruh effect. We use chiral perturbation theory at leading order and the large N limit (N being the number of pions) as an effective description of low-energy QCD, and the thermalization theorem to compute the relevant partition function for the accelerating observer. As a result, we obtain that chiral symmetry is restored for uniformly accelerated observers with acceleration a larger than the critical value a(c) = 4 pi f(pi), with f(pi) being the pion decay constant

Translational biomarker: identification of biomarkers related to capecitabine response in solid tumors by nucleic acids programmable protein microarrays (NAPPA), antibody arrays, IFISH and SNPS approaches

Comunicaciones a congreso

Redox-dependent and redox-independent functions of Caenorhabditis elegans thioredoxin 1

Thioredoxins (TRX) are traditionally considered as enzymes catalyzing redox reactions. However, redox-independent functions of thioredoxins have been described in different organisms, although the underlying molecular mechanisms are yet unknown. We report here the characterization of the first generated endogenous redox-inactive thioredoxin in an animal model, the TRX-1 in the nematode Caenorhabditis elegans. We find that TRX-1 dually regulates the formation of an endurance larval stage (dauer) by interacting with the insulin pathway in a redox-independent manner and the cGMP pathway in a redox-dependent manner. Moreover, the requirement of TRX-1 for the extended longevity of worms with compromised insulin signalling or under calorie restriction relies on TRX-1 redox activity. In contrast, the nuclear translocation of the SKN-1 transcription factor and increased LIPS-6 protein levels in the intestine upon trx-1 deficiency are strictly redox-independent. Finally, we identify a novel function of C. elegans TRX-1 in male food-leaving behaviour that is redox-dependent. Taken together, our results position C. elegans as an ideal model to gain mechanistic insight into the redox-independent functions of metazoan thioredoxins, overcoming the limitations imposed by the embryonic lethal phenotypes of thioredoxin mutants in higher organisms.NIH Office of Research Infrastructure P40 OD010440Spanish Ministry of Economy and Competitiveness BFU2015- 64408-PFondo Social Europeo BFU2015- 64408-PNational Institute of Allergy and Infectious Diseases of the National Institutes of Health R01AI07640