Voces: Experiences of Undocumented Latines

The purpose of this study was to learn about the challenges that this community faced before the pandemic and how they coped through those challenges. To answer this question, I examined transcripts from group interviews collected in the state of Texas. In total, there were 67 participants, many of whom were undocumented (n = 49) while the others had a relative or friend who was undocumented. Data were analyzed by looking for common patterns and themes in the transcripts, and guided by Critical Race Theory, Latine Critical Theory, and Undocumented Critical Theory. Results suggest that psychological distress is common not only for undocumented people but also for their loved ones who are not undocumented. Another major challenge was feeling limited by their undocumented status. Some undocumented participants also emphasized that they had been discriminated against by others, including by other Latines. Moreover, family was highly valued in this community, however, some participants stated that they felt disconnected from their families. In terms of strengths, results showed that problem solving is a major coping strategy for this community. Additionally, many participants reported using religion to remain hopeful and optimistic about their future

Prevalence of refractive error within a in Portuguese sample of optometric records

Purpose: Considering the burden of refractive error, clinical-based research methods are often used as epidemiological tools. This study aimed to generate evidence on the prevalence and distribution of refractive error in Portugal. Methods: A cross-sectional retrospective study was designed to review optometric records from Portuguese practices during July 2021. Results: 348 optometric records were analysed. Subjects had a mean age of 44.2 ± 19.2 years (range 6–81) and 58.4% were female. The mean spherical equivalent was myopic, −0.65 ± 2.38 Diopters (D), varying from a minimum of −13.63 to a maximum of 6.25 D. According to sex, the mean spherical equivalent was −0.76 ± 2.29 D for female and −0.49 ± 2.49 D for male, with no significant difference between them (p = .307). The distribution of the spherical equivalent mean across the age groups, linearly varies from a myopic −1.62 ± 1.74 D in the age group of [6 – 29]; −1.58 ± 2.80 D in [30 – 44]; −0.09 ± 2.40 in [45 – 59] to a hyperopic 0.67 ± 1.61 D in the group of [60 – 81]. High myopia had a prevalence of 2.7% in the sample. Myopia was the most prevalent refractive error in the sample representing 41.3%. In the age group [6–29], myopia had a prevalence of 69.3%. Hyperopia had a prevalence in the sample of 29.7%. Conclusions: Myopia represents the most prevalent refractive error within the sample and is the prevalence is higher in the younger age groups, demonstrating a shift towards an increase of myopia in the next years.(undefined

África, 14 kms. al sur de Europa. Análisis de los flujos migratorios entre el Norte de África y el Sur de Andalucía.

Dentro del Observatorio de las Migraciones en el Estrecho y Prevención de Efectos Indeseados se lleva a cabo un estudio que parte de dos fuentes de información: -Visiones y análisis de la inmigración reciente en Andalucía elaborados sobre fuentes secundarias. -Entrevistas en profundidad a personas migrantes e informantes expertos en el tema. A partir de esta información se facilita un material que puede ser muy útil para la reflexión y el debate, no sólo para profesionales de la investigación o de la intervención social, sino para cualquier persona interesada; se hacen propuestas concretas para promover vías de integración a quienes viven en nuestra comunidad, facilitar alternativas de futuro a potenciales inmigrantes y prevenir los efectos indeseados que produce la inmigración ilegal.Dirección General de Políticas Migratorias de la Junta de Andalucía. Fondo Social Europeo de la Unión Europea (Interreg III-A

Electrochromic polyoxometalate material as a sensor of bacterial activity

L. fermentum, a bacterium of human microbiota, acts as an electron donor to the electrochromic [P2MoVI18O62]6. Since, the reductive capacity of L. fermentum correlates with its metabolic activity, the reaction with [P2MoVI18O62]6- affords a means of evaluating its activity. Following this logic, we have concluded that vancomycin severely affects the activity of L. fermentum whereas omeprazole does not.FQM368 Bionanopartículas Metálicas (BioNanomet)Departamento de Química InorgánicaThis work was funded by MINECO and FEDER (project CTQ2012-32236

Self-Assembled Lanthanide Antenna Glutathione Sensor for the Study of Immune Cells

This work was supported by grants CTQ2017-85658-R, BFU2015-67284-R, and PID2019-104366RB-C22 funded by MCIN/AEI/10.13039/501100011033/FEDER "Una manera de hacer Europa"; grant PID2020-114256RB-I00 funded by MCIN/AEI/10.13039/501100011033; grant A-FQM-386-UGR20 funded by FEDER/Junta de Andalucia-Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades, and the CSIC grant 201580E073. Funding for open access charge: Universidad de Granada/CBUA.The small molecule 8-methoxy-2-oxo-1,2,4,5- tetrahydrocyclopenta[de]quinoline-3-carboxylic acid (2b) behaves as a reactive non-fluorescent Michael acceptor, which after reaction with thiols becomes fluorescent, and an efficient Eu3+ antenna, after self-assembling with this cation in water. This behavior makes 2b a highly selective GSH biosensor, which has demonstrated high potential for studies in murine and human cells of the immune system (CD4+ T, CD8+ T, and B cells) using flow cytometry. GSH can be monitored by the fluorescence of the product of addition to 2b (445 nm) or by the luminescence of Eu3+ (592 nm). 2b was able to capture baseline differences in GSH intracellular levels among murine and human CD4+ T, CD8+ T, and B cells. We also successfully used 2b to monitor intracellular changes in GSH associated with the metabolic variations governing the induction of CD4+ naiv̈ e T cells into regulatory T cells (TREG).MCIN/AEI/FEDER "Una manera de hacer Europa" CTQ2017-85658-R BFU2015-67284-R PID2019-104366RB-C22MCIN/AEI PID2020-114256RB-I00FEDER/Junta de Andalucia-Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades A-FQM-386-UGR20CSIC grant 201580E073Universidad de Granada/CBU

Cloud computing management in lysimetric stations with automatic supervision of digital images

[SPA] Con el avance de la tecnología han ido desarrollándose diferentes aplicaciones para el control y gestión de riego, desde los robustos dataloggers a los avanzados cRIO, permitiendo incluso por medio de módulos de comunicación y/o servidores web embebidos la visualización de los datos para ser visualizado por los usuarios. Como inconveniente presentan la utilización de diferentes lenguajes de programación y normas de funcionamiento que dificulta la integración de los diferentes sistemas de riego, el consumo de ancho de banda disponible y la limitación de memoria. Por medio de la presente investigación se ha realizado una novedosa aplicación PHP capaz de importar diferentes datos desde dataloggers y/o cRIO de forma autónoma, al utilizar protocolos estándar de comunicación (XML, JSON, CSV), además de incorporar un módulo para obtener de forma desatendida y automática la cobertura vegetal a partir de una fotografía digital. La aplicación está integrada en un sistema cloud computing que procesa los datos, pudiendo calcular las necesidades hídricas del cultivo utilizando algoritmos matemáticos, almacenar los datos para ser monitorizados y visualizados por cualquier dispositivo con navegador de Internet o exportarlos a un sistema de control de riego, por medio de protocolos estándar de comunicación. [ENG] With the technological advances, different applications for irrigation control and management have been developed. From the robust dataloggers to the advanced cRIO, the user data display is allowed by these devices by means of communication modules and/or embebbed Web servers. The disadvantage of these devices is the use of different programming languages and functionning standards. This is a difficulty because of the integration of different irrigation systems, the available bandwith consumption and the limitation of the memory. By means of the current development a novel PHP application is presented. This application is capable of import different data from dataloggers and/or cRIO with autonomous ways. This is due to the use of standard communication protocols (XML, JSON, CSV). Moreover a module for obtaining the vegetal coverture by means of an unattended and automatic way from a digital photography is incorporated. The application is integrated in a cloud computing system that processes the data. The crop water needs can be calculated using mathematical algorithms. Data can be collected to be monitored and visualised by any device with Internet browser. Additionally, data can be exported to irrigation management systems by means of communication standard protocols.Esta investigación se llevó a cabo gracias al apoyo del Grupo I+D+i Ingeniería Agromótica y del Mar de la Universidad Politécnica de Cartagena. Asimismo, agradecemos a la empresa TeleNatura EBT por su colaboración

Magneto-optical hyperthermia agents based on probiotic bacteria loaded with magnetic and gold nanoparticles

This work was funded by the Ministerio de Ciencia, Innovación y Universidades (MCIU), the Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER) through the projects PID2019- 111461GB-I00 to N.G. and J.M.DV, and PGC2018-096016-B-I00 to LG.). S.T. and J.J.C. acknowledge funding from the European Union’s Horizon 2020 research and innovation program under Grant 823717−ESTEEM3. A.G. acknowledges Junta de Andalucía for the postdoctoral contract within the PAIDI 2020 program (DOC_00791). Y.FA. thanks Santander-Universidad Zaragoza Fellowship program for her PhD position. J.M.D.L. acknowledges the financial support by the Spanish MCIN/AEI /10.13039/501100011033 through the project NanoSmart (RYC-2016-21042)Probiotic bacteria were used as carriers of metallic nanoparticles to develop innovative oral agents for hyperthermia cancer therapy. Two synthetic strategies were used to produce the different therapeutic agents. First, the probiotic bacterium Lactobacillus fermentum was simultaneously loaded with magnetic (MNPs) and gold nanoparticles (AuNPs) of different morphologies to produce AuNP+MNP-bacteria systems with both types of nanoparticles arranged in the same layer of bacterial exopolysaccharides (EPS). In the second approach, the probiotic was first loaded with AuNP to form AuNP-bacteria and subsequently loaded with MNP-EPS to yield AuNP-bacteria-EPS-MNP with the MNP and AuNP arranged in two different EPS layers. This second strategy has never been reported and exploits the presence of EPS–EPS recognition which allows the layer-by-layer formation of structures on the bacteria external wall. The AuNP+MNP-bacteria and AuNP-bacteria-EPS-MNP samples were characterized by scanning (SEM) and transmission electron microscopy (TEM), and UV-vis spectroscopy. The potential of these two heterobimetallic systems as magnetic hyperthermia or photothermal therapy agents was assessed, validating their capacity to produce heat either during exposure to an alternating magnetic field or a near-infrared laser light. The probiotic Lactobacillus fermentum has already been proposed as an oral drug carrier, able to overcome the stomach medium and deliver drugs to the intestines, and it is actually marketed as an oral supplement to reinforce the gut microbiota, thus, our results open the way for the development of novel therapeutic strategies using these new heterobimetallic AuNP/MNP-bacteria systems in the frame of gastric diseases, using them, for example, as oral agents for cancer treatment with magnetic hyperthermia and photothermal therapy.Ministerio de Ciencia, Innovación y Universidades (MCIU), the Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER) through the project PID2019- 111461GB-I00Ministerio de Ciencia, Innovación y Universidades (MCIU), the Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER) through the project PGC2018-096016-B-I00European Union’s Horizon 2020 research and innovation program under Grant 823717−ESTEEM3PAIDI 2020 program (DOC_00791)Spanish MCIN/AEI /10.13039/501100011033 through the project NanoSmart (RYC-2016-21042

Seeding and Growth of β-Amyloid Aggregates upon Interaction with Neuronal Cell Membranes

In recent years, the prevalence of amyloid neurodegenerative diseases such as Alzheimer’s disease (AD) has significantly increased in developed countries due to increased life expectancy. This amyloid disease is characterized by the presence of accumulations and deposits of β-amyloid peptide (Aβ) in neuronal tissue, leading to the formation of oligomers, fibers, and plaques. First, oligomeric intermediates that arise during the aggregation process are currently thought to be primarily responsible for cytotoxicity in cells. This work aims to provide further insights into the mechanisms of cytotoxicity by studying the interaction of Aβ aggregates with Neuro-2a (N2a) neuronal cells and the effects caused by this interaction. For this purpose, we have exploited the advantages of advanced, multidimensional fluorescence microscopy techniques to determine whether different types of Aβ are involved in higher rates of cellular toxicity, and we measured the cellular stress caused by such aggregates by using a fluorogenic intracellular biothiol sensor. Stress provoked by the peptide is evident by N2a cells generating high levels of biothiols as a defense mechanism. In our study, we demonstrate that Aβ aggregates act as seeds for aggregate growth upon interacting with the cellular membrane, which results in cell permeability and damage and induces lysis. In parallel, these damaged cells undergo a significant increase in intracellular biothiol levels.Spanish Ministerio de Ciencia, Innovacion y Universidades CTQ2014-56370-R CTQ2017-86568-R CTQ2017-86125-PSpanish Agencia Estatal de InvestigacionEuropean Union (EU

Spatial data infrastucture: development of spatial abilities in the framework of European Space for Higher Education

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Infraestructuras de datos espaciales: desarrollo de habilidades espaciales en el entorno del Espacio Europeo de Educación Superior

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