166 research outputs found

    Cruise Report R.V. Littorina, Cruise No.: L20-11

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    15.06. - 19.06.2020 Areas of research: Public relations and Aquarium West Shore Port Calls: Grenå DK (15.06. - 18.06.2020, 3 nights) Acquisition of living marine organisms for the public relations division (GEOMAR), the institute´s own aquarium and the Multimar Wattforum (Tönning) in the northern Kattegat

    Cruise Report F. K. Littorina L18-05 2018

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    Areas of research: Public relations and Aquarium West Shore Port Calls: Osterby / Lӕsø DK (15.05. - 16.05.2018) & Grenå DK (16.05. - 17.05.2018

    Super-resolution imaging of tight and adherens junctions: Challenges and open questions

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    The tight junction (TJ) and the adherens junction (AJ) bridge the paracellular cleft of epithelial and endothelial cells. In addition to their role as protective barriers against bacteria and their toxins they maintain ion homeostasis, cell polarity, and mechano-sensing. Their functional loss leads to pathological changes such as tissue inflammation, ion imbalance, and cancer. To better understand the consequences of such malfunctions, the junctional nanoarchitecture is of great importance since it remains so far largely unresolved, mainly because of major difficulties in dynamically imaging these structures at sufficient resolution and with molecular precision. The rapid development of super-resolution imaging techniques ranging from structured illumination microscopy (SIM), stimulated emission depletion (STED) microscopy, and single molecule localization microscopy (SMLM) has now enabled molecular imaging of biological specimens from cells to tissues with nanometer resolution. Here we summarize these techniques and their application to the dissection of the nanoscale molecular architecture of TJs and AJs. We propose that super-resolution imaging together with advances in genome engineering and functional analyses approaches will create a leap in our understanding of the composition, assembly, and function of TJs and AJs at the nanoscale and, thereby, enable a mechanistic understanding of their dysfunction in disease

    Die geneigten Vokale als Reflexe altpolnischer Laengen im Woerterbuch von Jan Mączyński

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    Das Lexikon von Jan Mączyński (Lexicon latino-polonicum ex optimis latinae linguae scriptoribus concinnatum - Ioanne Maczynski equite polono interprete, Regiomonti 1564) ist das erste große polnische Wörterbuch, dessen Entstehung in das 16. Jh. fällt, in ein Jahrhundert also, das auf allen Gebieten des geistigen Lebens in Polen Hervorragendes geleistet hat

    Wochenbericht L17-12

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    F.K. Littorina Cruise No.: L17-12 Date of cruise: 10.07. – 14.07.2017 Areas of research: Public relations and Aquarium West Shore Port Calls: Osterby / Lӕsø DK (11.07.-12.07.2017) & Grenå DK (12.07.-13.07.2017

    Die geneigten Vokale als Reflexe altpolnischer Laengen im Woerterbuch von Jan Mączyński

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    Das Lexikon von Jan Mączyński (Lexicon latino-polonicum ex optimis latinae linguae scriptoribus concinnatum - Ioanne Maczynski equite polono interprete, Regiomonti 1564) ist das erste große polnische Wörterbuch, dessen Entstehung in das 16. Jh. fällt, in ein Jahrhundert also, das auf allen Gebieten des geistigen Lebens in Polen Hervorragendes geleistet hat

    F.K. Littorina Cruise No.: L15-08 Cruise Report

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    Dates of Cruise: 4.5. – 7.5.2015 Areas of Research: Public relations and aquarium west shore Port Calls: Osterby/Laeso (4.5. – 7.5.2015
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