157 research outputs found
Plasmid encoding matrix protein of vesicular stomatitis viruses as an antitumor agent inhibiting rat glioma growth in situ
Aim: Oncolytic effect of vesicular stomatitis virus (VSV) has been proved previously. Aim of the study is to investigate glioma inhibition effect of Matrix (M) protein of VSV in situ. Materials and Methods: A recombinant plasmid encoding VSV M protein (PM) was genetically engineered, and then transfected into cultured C6 gliomas cells in vitro. C6 transfected with Liposome-encapsulated PM (LEPM) was implanted intracranially for tumorigenicity study. In treatment experiment, rats were sequentially established intracranial gliomas with wild-typed C6 cells, and accepted LEPM injection intravenously. Possible mechanism of M protein was studied by using Hoechst staining, PI-stained flow cytometric analysis, TUNEL staining and CD31 staining. Results: M protein can induce generous gliomas lysis in vitro. None of the rats implanted with LEPM-treated cells developed any significant tumors, whereas all rats in control group developed tumors. In treatment experiment, smaller tumor volume and prolonged survival time was found in the LEPM-treated group. Histological studies revealed that possible mechanism were apoptosis and anti-angiogenesis. Conclusion: VSV-M protein can inhibit gliomas growth in vitro and in situ, which indicates such a potential novel biotherapeutic strategy for glioma treatment.Π¦Π΅Π»Ρ: ΠΈΠ·ΡΡΠΈΡΡ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΠΌΠ°ΡΡΠΈΠΊΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΠΈΠ½Π° (Π ΠΏΡΠΎΡΠ΅ΠΈΠ½Π°) Π²ΠΈΡΡΡΠ° Π²Π΅Π·ΠΈΠΊΡΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΡΡΠΎΠΌΠ°ΡΠΈΡΠ° (ΠΠΠ‘) ΡΠ³Π½Π΅ΡΠ°ΡΡ ΡΠΎΡΡ Π³Π»ΠΈΠΎΠΌΡ
in situ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ: ΡΠΊΠΎΠ½ΡΡΡΡΠΈΡΠΎΠ²Π°Π½Π° ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½Π°Ρ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π°, ΠΊΠΎΠ΄ΠΈΡΡΡΡΠ°Ρ Π ΠΏΡΠΎΡΠ΅ΠΈΠ½ ΠΠΠ‘, ΠΊΠΎΡΠΎΡΠ°Ρ Π·Π°ΡΠ΅ΠΌ Π±ΡΠ»Π°
ΡΡΠ°Π½ΡΡΠ΅ΡΠΈΡΠΎΠ²Π°Π½Π° Π² ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ Π³Π»ΠΈΠΎΠΌΡ Π‘6 in. ΠΠ»Π΅ΡΠΊΠΈ Π³Π»ΠΈΠΎΠΌΡ Π‘6, ΡΡΠ°Π½ΡΡΠ΅ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ ΠΈΠ½ΠΊΠ°ΠΏΡΡΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ
Π² Π»ΠΈΠΏΠΎΡΠΎΠΌΡ Π ΠΏΡΠΎΡΠ΅ΠΈΠ½ΠΎΠΌ (ΠΠΠΠ), ΠΈΠΌΠΏΠ»Π°Π½ΡΠΈΡΠΎΠ²Π°Π»ΠΈ ΠΈΠ½ΡΡΠ°ΠΊΡΠ°Π½ΠΈΠ°Π»ΡΠ½ΠΎ Π΄Π»Ρ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΡΡΠΌΠΎΡΠΎΠ³Π΅Π½Π½ΠΎΡΡΠΈ. Π ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ΅ ΠΊΡΡΡΠ°ΠΌ
Ρ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΈΠ½ΡΡΠ°ΠΊΡΠ°Π½ΠΈΠ°Π»ΡΠ½ΠΎ Π³Π»ΠΈΠΎΠΌΠΎΠΉ Π‘6 (ΠΈΡΡ
ΠΎΠ΄Π½ΡΠΉ ΡΡΠ°ΠΌΠΌ) Π²Π½ΡΡΡΠΈΠ²Π΅Π½Π½ΠΎ Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΠΠΠ. ΠΠΏΠΎΠΏΡΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅
Π ΠΏΡΠΎΡΠ΅ΠΈΠ½Π° Π½Π° ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ ΠΈΠ·ΡΡΠ°Π»ΠΈ Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠ΅Π½ΡΠ½ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΠΈ (ΠΎΠΊΡΠ°ΡΠΈΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎ Π₯Π΅Ρ
ΡΡΡ),
ΠΏΡΠΎΡΠΎΡΠ½ΠΎΠΉ ΡΠΈΡΠΎΠΌΠ΅ΡΡΠΈΠΈ (ΠΎΠΊΡΠ°ΡΠΈΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΠΏΠΈΠ΄ΠΈΡΠΌΠΎΠΌ ΠΉΠΎΠ΄ΠΈΠ΄ΠΎΠΌ), TUNEL Π²Π°ΡΠΊΡΠ»ΡΡΠΈΠ·Π°ΡΠΈΡ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ ΠΈ Π²Π°ΡΠΊΡΠ»ΡΡΠΈΠ·Π°ΡΠΈΡ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ ΠΈ
ΠΈΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈ Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ Π°Π½ΡΠΈ-CD31 ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΡ
Π°Π½ΡΠΈΡΠ΅Π». 31 ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΡ
Π°Π½ΡΠΈΡΠ΅Π». 31 ΠΌΠΎΠ½ΠΎΠΊΠ»ΠΎΠ½Π°Π»ΡΠ½ΡΡ
Π°Π½ΡΠΈΡΠ΅Π». Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ: Π ΠΏΡΠΎΡΠ΅ΠΈΠ½ ΠΌΠΎΠΆΠ΅Ρ ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°ΡΡ
Π»ΠΈΠ·ΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π³Π»ΠΈΠΎΠΌΡ in. ΠΠΈ Ρ ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΆΠΈΠ²ΠΎΡΠ½ΠΎΠ³ΠΎ Ρ ΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌΠΈ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌΠΈ Π³Π»ΠΈΠΎΠΌΡ, ΠΎΠ±ΡΠ°Π±ΠΎΡΠ°Π½Π½ΡΠΌΠΈ ΠΠΠΠ,
Π½Π΅ Π²ΠΎΠ·Π½ΠΈΠΊΠ°Π»ΠΈ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ°Π·ΠΌΠ΅ΡΠ°, ΡΠΎΠ³Π΄Π° ΠΊΠ°ΠΊ Ρ Π²ΡΠ΅Ρ
ΠΊΡΡΡ ΠΈΠ· ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ ΡΠ°Π·Π²ΠΈΠ²Π°Π»ΠΈΡΡ. Π Π³ΡΡΠΏΠΏΠ΅
ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
, ΠΊΠΎΡΠΎΡΡΠΌ Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΠΠΠ, ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ Π±ΡΠ»ΠΈ ΠΌΠ΅Π½ΡΡΠ΅Π³ΠΎ ΠΎΠ±ΡΠ΅ΠΌΠ° ΠΈ ΠΎΡΠΌΠ΅ΡΠ°Π»ΠΈ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΆΠΈΠ·Π½ΠΈ
ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π ΠΏΡΠΎΡΠ΅ΠΈΠ½ ΠΏΡΠΎΡΠ²Π»ΡΠ΅Ρ Π°Π½ΡΠΈΠ°Π½Π³ΠΈΠΎΠ³Π΅Π½Π½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΠΈ ΠΎΠ±Π»Π°Π΄Π°Π΅Ρ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡΡ ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°ΡΡ Π°ΠΏΠΎΠΏΡΠΎΠ·.
ΠΡΠ²ΠΎΠ΄Ρ: Π ΠΏΡΠΎΡΠ΅ΠΈΠ½ ΠΠΠ‘ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΡΠ΅Ρ ΡΠΎΡΡ Π³Π»ΠΈΠΎΠΌΡ in ΠΈ in. ΠΠ° ΡΡΠΎΠΉ ΠΎΡΠ½ΠΎΠ²Π΅ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π° ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎ Π½ΠΎΠ²Π°Ρ
Π±ΠΈΠΎΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΡΡΠ°ΡΠ΅Π³ΠΈΡ Π΄Π»Ρ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π³Π»ΠΈΠΎΠΌΠ°ΠΌΠΈ
Direct Measurements of the Branching Fractions for and and Determinations of the Form Factors and
The absolute branching fractions for the decays and
are determined using singly
tagged sample from the data collected around 3.773 GeV with the
BES-II detector at the BEPC. In the system recoiling against the singly tagged
meson, events for and events for decays are observed. Those yield
the absolute branching fractions to be and . The
vector form factors are determined to be
and . The ratio of the two form
factors is measured to be .Comment: 6 pages, 5 figure
Search for the Lepton Flavor Violation Processes and
The lepton flavor violation processes and are
searched for using a sample of 5.8 events collected with
the BESII detector. Zero and one candidate events, consistent with the
estimated background, are observed in and
decays, respectively. Upper limits on the branching ratios are determined to be
and at the 90% confidence level (C.L.).Comment: 9 pages, 2 figure
The pole in
Using a sample of 58 million events recorded in the BESII detector,
the decay is studied. There are conspicuous
and signals. At low mass, a large
broad peak due to the is observed, and its pole position is determined
to be - MeV from the mean of six analyses.
The errors are dominated by the systematic errors.Comment: 15 pages, 6 figures, submitted to PL
Observation of the decay \psip\rar\kstark
Using 14 million events collected with the BESII detector,
branching fractions of \psip\rar\kstarkpm and \kstarknn are determined to
be: \calB(\psip\rar\kstarkpm)=(2.9^{+1.3}_{-1.7}\pm0.4)\times 10^{-5} and
\calB(\psip\rar\kstarknn)=(13.3^{+2.4}_{-2.7}\pm1.9)\times 10^{-5}. The
results confirm the violation of the "12%" rule for these two decay channels
with higher precision. A large isospin violation between the charged and
neutral modes is observed.Comment: 5 pages, 3 figure
Measurement of Branching Ratios for Hadronic Decays
In a sample of 58 million events collected with the BES II detector,
the process J/ is observed in five decay channels: , , (with
), (with ) and . From
these signals, we determine ,
, ,
and .Comment: 8 pages, 1 figures and 4 table. Submitted to Phys. Lett.
Measurements of J/psi --> p \bar{p}
The process J/\psi --> p \bar{p} is studied using 57.7 X 10^6 J/\psi events
collected with the BESII detector at the Beijing Electron Positron Collider.
The branching ratio is determined to be Br(J/\psi --> p \bar{p})=(2.26 +- 0.01
+- 0.14) X 10^{-3}, and the angular distribution is well described by
\frac{dN}{d cos\theta_p}=1+\alpha\cos^2\theta_p with \alpha = 0.676 +- 0.036 +-
0.042, where \theta_p is the angle between the proton and beam directions. The
value of \alpha obtained is in good agreement with the predictions of
first-order QCD.Comment: 6 pages, 2 figures, RevTex4, Submitted to Phys.Lett.
Search for K_S K_S in J/psi and psi(2S) decays
The CP violating processes J/psi-->K_S K_S and psi(2S)-->K_S K_S are searched
for using samples of 58 million J/psi and 14 million psi(2S) events collected
with the Beijing Spectrometer at the Beijing Electron Positron Collider. No
signal is observed, and upper limits on the decay branching ratios are
determined to be BR(J/psi-->K_S K_S) K_S K_S) <
4.6x10^{-6} at the 95% confidence level.Comment: 6 pages, 4 figures, submitted to Phys. Lett.
A Study of J/psi-->gamma gamma V(rho,phi) Decays with the BESII Detector
Using a sample of events collected with the BESII
detector, radiative decays , where or ,
are studied. A resonance around 1420 MeV/c (X(1424)) is observed in the
mass spectrum. Its mass and width are measured to be MeV/c and MeV/c,
respectively, and its branching ratio is determined to be . A
search for yields a 95% C.L. upper limit .Comment: 10 pages, 5 figures, submitted to PL
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