Askin's Tumor in an Adult: Case Report and Findings on 18F-FDG PET/CT

Primitive neuroectodermal tumor (PNET) of the chest wall or Askin's tumor is a rare neoplasm of chest wall. It most often affects children and adolescents and is a very rare tumor in adults. In this case report, we present an Askin's tumor occurred in a 73-year-old male. The patient was admitted with a history of 3-month lower back pain and cough. In computed tomography, there was a lesion with dimensions of 70 × 40 × 65 mm in the superior segment of the lower lobe of the left lung. Positron emission tomography/computed tomography with 18F-flourodeoxyglucose revealed a pleural-based tumor in the left lung with a maximum standardized uptake value of 4.36. No distant or lymph node metastases were present. The patient had gone through surgery, and wedge resection of the superior segment of left lobe and partial resection of the ipsilateral ribs were performed. Pathology report with immunocytochemistry was consistent with PNET and the patient received chemotherapy after that

Comparison of the diagnoses, the outpatient clinics they visited, and the number of visits of patients with and without a diagnosis of fibromyalgia syndrome: Do patients with fibromyalgia syndrome come to the hospital more often? [Fibromiyalji sendromu tanısı olan ve olmayan hastaların başvurdukları poliklinik bölümleri, başvuru sayıları ve aldıkları tanıların karşılaştırılması: Fibromiyalji sendromu tanısı olan hastalar, hastaneye daha mı sık geliyor?]

Summary Objectives: Fibromyalgia syndrome (FMS) has a wide spectrum of symptoms that includes all body parts. So FMS is a great imitator. This brings to mind the possibility that fibromyalgia patients visit outpatient clinics in many departments more than non-fibromyalgia patients. However, there is not enough data on this subject. This study aims to compare the number of outpatient visits of patients with FMS with those without a diagnosis of FMS and to examine their diagnoses. Methods: The diagnoses of 140 patients (70 with fibromyalgia and 70 controls), and departments of the outpatient clinics they visited were analyzed retrospectively. In the control group, patients who visited the same outpatient clinic with the complaint of knee pain, but who did not have FMS and who had never been diagnosed with FMS before, were recruited as age- and gender-matched. Results: The total number of outpatient clinic visits, as well as the number of visits to physical medicine and rehabilitation, obstetrics and gynecology, general surgery, internal medicine, and psychiatry departments, were significantly higher in fibromyalgia group patients compared to the control group. In addition, the number of diagnoses in the 5th chapter (mental, behavioral, and neurodevelopmental disorders, F01-F99) of International Classification of Diseases-10 was significantly higher in the fibromyalgia group. Conclusion: It should be kept in mind that patients with FMS visit more hospitals and outpatient clinics than other patients. Physicians and patients should be informed about this issue to reduce unnecessary health costs

Effect of Caffeic Acid Phenethyl Ester on Vascular Damage Caused by Consumption of High Fructose Corn Syrup in Rats

Fructose corn syrup is cheap sweetener and prolongs the shelf life of products, but fructose intake causes hyperinsulinemia, hypertriglyceridemia, and hypertension. All of them are referred to as metabolic syndrome and they are risk factors for cardiovascular diseases. Hence, the harmful effects of increased fructose intake on health and their prevention should take greater consideration. Caffeic Acid Phenethyl Ester (CAPE) has beneficial effects on metabolic syndrome and vascular function which is important in the prevention of cardiovascular disease. However, there are no known studies about the effect of CAPE on fructoseinduced vascular dysfunction. In this study, we examined the effect of CAPE on vascular dysfunction due to high fructose corn syrup (HFCS). HFCS (6 weeks, 30% fed with drinking water) caused vascular dysfunction, but treatment with CAPE (50 micromol/kg i.p. for the last two weeks) effectively restored this problem. Additionally, hypertension in HFCS-fed rats was also decreased in CAPE supplemented rats. CAPE supplements lowered HFCS consumption-induced raise in blood glucose, homocysteine, and cholesterol levels. The aorta tissue endothelial nitric oxide synthase (eNOS) production was decreased in rats given HFCS and in contrast CAPE supplementation efficiently increased its production. The presented results showed that HFCS-induced cardiovascular abnormalities could be prevented by CAPE treatment

Gebelikte Tütün Dumanı Maruziyetinin Anne Sıçan Akciğer Dokusunda Meydana Getirdiği Değişiklikler Üzerine Alfa Lipoik Asitin Etkilerinin İncelenmesi

Amaç: Çalışmamızda gebelikte tütün dumanına maruz kalan anne sıçanların akciğer dokusunda meydana gelen değişiklikler üzerine alfa lipoik asitin etkilerinin deneysel sıçan modeli üzerinde araştırılması amaçlandı. Yöntemler: Çalışmada 28 adet dişi Sprague-Dawley cinsi sıçanlar kullanıldı. Gebe sıçanlar; Kontrol grubu, Tütün dumanı (TD) grubu, Tütün dumanı + Alfa lipoik asit (TD+ALA) grubu ve Alfa lipoik asit (ALA) grubu olmak üzere rastgele dört eşit gruba ayrıldı. TD ve TD+ALA grubundaki sıçanlar çiftleşmeden önce sekiz hafta ve gebelik süresince günde iki saat tütün dumanına maruz bırakıldı. TD+ALA ve ALA grubundaki sıçanlara ise çiftleşmeden önce sekiz hafta ve gebelik süresince gün aşırı oral gavaj yolu ile 20 mg/kg dozunda alfa lipoik asit verildi. Deneyin sonunda sıçanlar dekapite edilerek akciğer dokuları çıkarıldı ve histolojik, biyokimyasal ve immünohistokimyasal metotlar uygulandı. Bulgular: TD grubuna ait akciğer kesitlerinde inflamatuar hücre artışı, konjesyon, ödem, hemoraji gibi histopatolojik bulgular gözlendi. ALA uygulamasıyla bu histopatalojik bulgularda istatistiksel olarak anlamlı oranda düzelmeler izlendi. TD grubunda VEGF immünreaktivitesinin kontrol grubuna göre anlamlı artış gösterdiği, TD+ALA grubunda ise TD grubuna göre VEGF immünreaktivitesinin anlamlı derecede azaldığı belirlendi. TD grubunda MDA değerlerinin kontrole göre anlamlı derecede arttığı, TD+ALA grubunda ise TD grubuna göre anlamlı derecede azaldığı gözlendi. Sonuç: Tütün dumanının gebe sıçan akciğerinde yol açtığı oksidatif hasarın, alfa lipoik asit tedavisinin antioksidan etkileri ile kısmen engellendiği belirlendi

Parental psychological distress associated with COVID-19 outbreak: A large-scale multicenter survey from Turkey

Aims: Pandemics can cause substantial psychological distress; however, we do not know the impact of the COVID-19 related lockdown and mental health burden on the parents of school age children. We aimed to comparatively examine the COVID-19 related the stress and psychological burden of the parents with different occupational, locational, and mental health status related backgrounds. Methods: A large-scale multicenter online survey was completed by the parents (n = 3,278) of children aged 6 to 18 years, parents with different occupational (health care workers—HCW [18.2%] vs. others), geographical (İstanbul [38.2%] vs. others), and psychiatric (child with a mental disorder [37.8%]) backgrounds. Results: Multivariable logistic regression analysis showed that being a HCW parent (odds ratio 1.79, p <.001), a mother (odds ratio 1.67, p <.001), and a younger parent (odds ratio 0.98, p =.012); living with an adult with a chronic physical illness (odds ratio 1.38, p <.001), having an acquaintance diagnosed with COVID-19 (odds ratio 1.22, p =.043), positive psychiatric history (odds ratio 1.29, p <.001), and living with a child with moderate or high emotional distress (odds ratio 1.29, p <.001; vs. odds ratio 2.61, p <.001) were independently associated with significant parental distress. Conclusions: Parents report significant psychological distress associated with COVID-19 pandemic and further research is needed to investigate its wider impact including on the whole family unit. © The Author(s) 2020

The frequency of Duchenne muscular dystrophy/Becker muscular dystrophy and Pompe disease in children with isolated transaminase elevation: results from the observational VICTORIA study

IntroductionElevated transaminases and/or creatine phosphokinase can indicate underlying muscle disease. Therefore, this study aims to determine the frequency of Duchenne muscular dystrophy/Becker muscular dystrophy (DMD/BMD) in male children and Pompe disease (PD) in male and female children with isolated hypertransaminasemia.MethodsThis multi-center, prospective study enrolled patients aged 3–216 months with serum alanine transaminase (ALT) and/or aspartate transaminase (AST) levels &gt;2× the upper limit of normal (ULN) for ≥3 months. Patients with a known history of liver or muscle disease or physical examination findings suggestive of liver disease were excluded. Patients were screened for creatinine phosphokinase (CPK) levels, and molecular genetic tests for DMD/BMD in male patients and enzyme analysis for PD in male and female patients with elevated CPK levels were performed. Genetic analyses confirmed PD. Demographic, clinical, and laboratory characteristics of the patients were analyzed.ResultsOverall, 589 patients [66.8% male, mean age of 63.4 months (standard deviation: 60.5)] were included. In total, 251 patients (188 male and 63 female) had CPK levels above the ULN. Of the patients assessed, 47% (85/182) of male patients were diagnosed with DMD/BMD and 1% (3/228) of male and female patients were diagnosed with PD. The median ALT, AST, and CPK levels were statistically significantly higher, and the questioned neurological symptoms and previously unnoticed examination findings were more common in DMD/BMD patients than those without DMD/BMD or PD (p &lt; 0.001).DiscussionQuestioning neurological symptoms, conducting a complete physical examination, and testing for CPK levels in patients with isolated hypertransaminasemia will prevent costly and time-consuming investigations for liver diseases and will lead to the diagnosis of occult neuromuscular diseases. Trial RegistrationClinicaltrials.gov NCT04120168

Treatment of olive oil mill wastewater with investigation using physicochemical and advanced methods in pilot plant scale

Dünya zeytin üretiminin %65'i, zeytinyağı üretiminin %76'sı AB ülkeleri tarafından gerçekleştirilmektedir. Zeytin ve zeytinyağı üreten Avrupa Birliği'nin önemli üretici ülkeleri, İspanya, İtalya, Yunanistan ve Portekiz'dir. Zeytinyağı üretimi sırasında yan ürün olarak pirina ve karasu oluşmaktadır. Çok yüksek organik kirliliğe sahip olan karasuyun, alıcı ortamlara ve araziye gelişigüzel bırakılması önemli çevre sorunlarına neden olmaktadır. SKKY'nde 2 saatlik/24 saatlik kompozit karasu numunesi için deşarj kriterleri, KOİ için 250/230 mg/L, yağ-gres için 60/40 mg/L ve pH için 6-9 olmalıdır. Ancak zeytin ağaçlarında görülen periyodisite (var-yok yılı), yağhanelerin küçük ve dağınık olması, sezonluk üretim ve çok yoğun organik kirlilik nedeniyle, yönetmelikte bu kriterlerin klasik arıtma yöntemleriyle sağlanması çok zordur.Bu çalışmada, Bursa ilinde faaliyet gösteren Marmarabirlik Zeytinyağı Fabrikası'na kurulan pilot tesisten alınan karasu örneklerine, asit kraking ve fizikokimyasal arıtma uygulanmıştır. Daha sonra ultrafiltrasyon prosesinden geçirilen atıksuda ters osmoz ve GAC kullanılarak adsorpsiyon proseslerinin uygulanabilirliği araştırılmıştır. Son olarak karasuyun akım şeması oluşturulmuş ve atıksu arıtma tesisi boyutlandırılmıştır.Ham atıksuyun karakterizasyonu, pH=4.91, KOİ=128 g/L, AKM=36.3 g/L, yağ-gres=8.92 g/L, fenol=3.44 g/L olarak bulunmuştur. Karakterizasyonu belirlenen karasuda arıtılabilirlik çalışmaları yapılmıştır. Adsorpsiyonla yapılan arıtılabilirlik çalışmaları sonucunda adsorplama kapasite değeri, Q0=434.28 mg KOİ/g GAC olarak bulunmuştur. Ters osmoz prosesleriyle karasuda %93 oranında giderme verimi sağlanmıştır.Sonuç olarak zeytinyağı endüstrisi atıksularının sırasıyla asit kraking, fizikokimyasal arıtma, ultrafiltrasyon proseslerinden geçirildikten sonra ters osmoz veya adsorpsiyon prosesleriyle arıtılabileceği tespit edilmiştir.EU countries realize 65% percent of the world?s olive production, and 76% of olive oil production. The important producer countries of EU, which produce olives and olive oil, are Spain, Italy, Greece and Portugal. Olive oil cake and black water are produced as side products during olive oil production. Releasing black water, which has a very high organic contamination load, in aqueous environments haphazardly causes important environmental problems. According to regulation for 2 hour/24 hour composite black water must be reduced 250/230 mg/L COD, 60/40 mg/L oil-grease, 6-9 pH before discharging it to recipient environment. However, because of the periodicity (good and bad years), smallness and scarcity of factories, a short campaign period and a very intense organic contamination load, it is almost impossible to meet this condition with the classical methods of treatment.In this study, first of all it is carried out acid-cracking experiment on black water which is taken Marmarabirlik Olive Oil Factory in Bursa. Then it is made physicochemical treatment, ultrafiltration and reverse osmos or adsorption process, it is searched that the suitability, using activated carbon on wastewater. After that flow diagram of black water is prepared and treatment plant is designed.The characterization of raw wastewater, pH=4.91, COD=128 g/L, TSS=36.3 g/L, oil-grease=8.92 g/L, phenol=3.44 g/L is found. After the defination of characterization is made treatability studies. The adsorption capasity is found Q0=434.28 mg COD/g GAC by the result of adsorption process. The removal efficiency is obtained 93% in reverse osmos process.The result of this study, it is determined that wastewater of olive oil industry can be treated by reverse osmos or the adsorption process after acid-cracking, physicochemical treatment and ultrafiltration

Effects of lipids on inflammation and DNA damage in diabetes mellitus patients

We aimed to see the effect of lipids on 8-hydroxy-2&apos;-deoxyguanosine (8-OHdG), a marker of DNA damage, and Interleukin-6 (IL-6), an inflammatory cytokine, in Diabetes Mellitus (DM) patients. Serum IL-6, and 8-OHdG levels were determined using kits based on the ELISA principle. The groups were different in terms of total cholesterol, LDL cholesterol and triglyceride. Group 2 (dyslipidemia positive DM positive) was significantly higher than the other groups. There was no statistical difference between group 1 (dyslipidemia negative DM positive) and the control group (p [Med-Science 2023; 12(3.000): 910-4

Sustainability in Sight : A Hermeneutical study of Visby`s tourism planning

Normal 0 MicrosoftInternetExplorer4 Purpose: The purpose of this essay is to get a comprehensive understanding for the thoughts behind Visby’s sustainable tourism planning. Focus will lie on how far Visby has come in their planning and implementing towards a sustainable tourism development. Methods: This study is preceded from a hermeneutical and constructive perspective. The methods used are induction and qualitative research in the form of deep interviews with four key figures working within Gotland’s municipality and tourism industry. The data collection has also been through secondary data and document studies. Results: The results of this study shows that sustainability as a thought is present in the Gotland’s municipality’s planned development for Visby. Visby is in an early stage of its planning towards a sustainable tourism development