Bank Failure: Evidence from the Colombia Financial Crisis

This paper identifies the main bank specific determinants of bank failure during the financial crisis in Colombia using duration analysis. Using partial likelihood estimation, it shows that the process of failure of financial institutions during that period can be explained by differences in financial health and prudence across institutions. The capitalization ratio is the most significant indicator explaining bank failure. Increases in this ratio lead to a reduction in the hazard rate of failure at any given moment in time. Of special relevance, this ratio exhibits a non-linear component. Our results thus provide empirical support for existing regulatory practice. Other important variables explaining bank failure dynamics are bank's size and profitability.

Classifying and valuing ecosystem services for urban planning

While technological progress has fostered the conception of an urban society that is increasingly decoupled from ecosystems, demands on natural capital and ecosystem services keep increasing steadily in our urbanized planet. Decoupling of cities from ecological systems can only occur locally and partially, thanks to the appropriation of vast areas of ecosystem services provision beyond the city boundaries. Conserving and restoring ecosystem services in urban areas can reduce the ecological footprints and the ecological debts of cities while enhancing resilience, health, and quality of life for their inhabitants. In this paper we synthesize knowledge and methods to classify and value ecosystem services for urban planning. First, we categorize important ecosystem services and disservices in urban areas. Second, we describe valuation languages (economic costs, socio-cultural values, resilience) that capture distinct value dimensions of urban ecosystem services. Third, we identify analytical challenges for valuation to inform urban planning in the face of high heterogeneity and fragmentation characterizing urban ecosystems. The paper discusses various ways through which urban ecosystems services can enhance resilience and quality of life in cities and identifies a range of economic costs and socio-cultural impacts that can derive from their loss. We conclude by identifying knowledge gaps and challenges for the research agenda on ecosystem services provided in urban areasacceptedVersio

Mechanisms of Ewing sarcoma development and therapeutic resistance

Many large scale consortia have begun to use high-throughput sequencing technologies to identify key mutations and pathways involved in the etiology of cancers. Identification of specific mutations within tumors can also influence patient-directed therapeutic decisions. Recent evidence implicates the insulin-like growth factor pathway in development of Ewing Sarcoma, a highly malignant bone and soft tissue tumor that primarily affects children and young adults. Despite promising results from preclinical studies of therapies that target this pathway, early phase clinical trials have shown that a significant fraction of patients do not benefit, suggesting that cellular factors determine tumor sensitivity. All cases of Ewing sarcoma are characterized by a translocation between EWSR1 and an ETS-family transcription factor where 85% of the cases result in the EWSR1-FLI1 t(11;22)(q24:q12). This novel transcription factor is retargeted to a subset of repetitive elements in a cell-type specific manner by a previously unknown mechanism. In the chapters that follow, we describe the cellular consequences of PTEN loss in Ewing sarcoma as well as a mechanism for EWSR1-FLI1 retargeting. We demonstrate that Ewing sarcoma cells with PTEN loss exhibited increased transformative properties, as well as reciprocal sensitivity to IGF-1R and mTOR inhibition, therapies currently undergoing testing in clinical trials. In addition, our studies also describe a novel chromatin environment of stem cells in which repetitive elements are enriched in accessible chromatin. Strikingly, a subset of accessible repetitive elements in stem cells is associated with Ewing Sarcoma development. Repetitive elements exhibiting the greatest FAIRE signal in stem cells, is associated with increased EWSR1-FLI1 binding, suggesting the chromatin environment of stem cells is primed for oncogenesis. Taken together, these studies expand our knowledge of Ewing sarcoma etiology and provide a potential mechanism for therapy resistance. This work serves as the foundation for both expanded preclinical and clinical research for future targeted therapies in Ewing sarcoma.Doctor of Philosoph

Method and process for the production of multi-coated recognitive and releasing systems

The present invention includes compositions, methods, systems for the controlled delivery of an active agent in a tablet polymer comprising two or more layers, wherein each of the two or more layers comprises at least one active agent and at least one molecular recognition polymer, wherein the two or more layers are compressed into a single tablet.Board of Regents, University of Texas Syste

Workflow Optimization of World Micro, Inc. Quality Department

Our group member Nick is currently an intern at World Micro, which is an electronic components distributor for companies manufacturing a variety of commercial, aerospace and military products. When electrical components are purchased from the open market, they need to be traced back to the OEM (Original Equipment Manufacturer) or have a series of tests performed to verify that the parts are authentic and work. The current process time for World Micro’s quality testing and inspection is not efficient causing long lead times, extra work hours, and extra expenses in outsourcing services

Detection of rapid orbital expansion of Saturn’s moon Titan

The Saturn satellite system is a complex dynamical system with several gravitational interactions happening between the satellites, the rings and the central body, such as resonances, librations and tides. These intricate dynamics carry information on the formation and evolution of the Saturn and Solar systems

Parental Concerns about the Health of Adolescents with Intellectual Disability: A Brief Report

Background. Parents of adolescents with intellectual disability are concerned about the future health and well-being needs of their children. Method. Qualitative data was collected as part of a cross-sectional descriptive study and semi-structured interviews were conducted with 32 parents. The results were themed. Results. Most parents discussed areas of their children's health which made them anxious about the future. These concerns were collated into five themes. Conclusion. The health and well-being themes were dependency, general health, challenging behaviours, and increasing support needs

Grain boundary networks and shape preferred orientation : A fresh angle on pattern quantification with GBPaQ

A quantitative understanding of grain shape preferred orientation (SPO) and grain boundary networks as fundamental characteristics of rocks and other crystalline solids is of major interest in geology and material science. Grain boundary networks contain useful information on the deformation history of polycrystalline aggregates, and their diagenetic and metamorphic histories. SPO can have a major impact on material characteristics such as permeability, acoustic velocity and mechanical strength, and on reaction surfaces. The objective of this study is to present a semi-automated toolbox of MATLAB™ scripts, named Grain Boundary Pattern Quantification (GBPaQ), that incorporate different methods for grain boundary pattern quantification for their application to, for example, seismic wave attenuation estimation. GBPaQ uses grain boundary statistics and calculates radial scan line intercepts. In this paper, GBPaQ is tested on two example grain boundary patterns, a granular texture and a foam texture with equant grains, which have been digitally stretched (deformed) to analyse their SPO evolution. The results show that a combination of grain ellipse, grain boundary segment orientation, and grain boundary segment intercept density rose diagrams provide a complete, detailed quantification of grain boundary pattern anisotropy. Grain boundary segment intercept (GBSI) analysis using GBPaQ yields a new grain boundary network parameter – the minimum intensity of grain boundary intercepts (Imin) – which follows a power law relationship with the average axial ratio of grain-fitted ellipses (r) during SPO development. We propose that Imin can be used for the quantitative analysis of SPO strength as a useful tool to assess the deformation history of polycrystalline aggregates. Further studies involving a broader range of different patterns and strain histories are necessary to fully investigate the potential of Imin versus r diagrams

Rapid hydration and weakening of anhydrite under stress : Implications for natural hydration in the Earth’s crust and mantle

Acknowledgements JThis research has been supported by an Aberdeen–Curtin Alliance international postgraduate scholarship, by a Curtin publication grant, and by the Natural Environment Research Council (grant no. NE/T007826/1). Enrique Gomez-Rivas acknowledges the “Ramón y Cajal” fellowship RYC2018-026335-I, funded by the Spanish Ministry of Science and Innovation (MCIN), the State Research Agency of Spain (AEI), and the European Social Fund (ESF)/10.13039/501100011033, as well as the DGICYT research project PID2020-118999GB-I00, funded by the Spanish Ministry of Science and Innovation (MCIN) and State Research Agency of Spain (AEI)/10.13039/501100011033.Peer reviewedPublisher PD

Microtubule organization is determined by the shape of epithelial cells.

Interphase microtubule organization is critical for cell function and tissue architecture. In general, physical mechanisms are sufficient to drive microtubule organization in single cells, whereas cells within tissues are thought to utilize signalling mechanisms. By improving the imaging and quantitation of microtubule alignment within developing Drosophila embryos, here we demonstrate that microtubule alignment underneath the apical surface of epithelial cells follows cell shape. During development, epidermal cell elongation and microtubule alignment occur simultaneously, but by perturbing cell shape, we discover that microtubule organization responds to cell shape, rather than the converse. A simple set of microtubule behaviour rules is sufficient for a computer model to mimic the observed responses to changes in cell surface geometry. Moreover, we show that microtubules colliding with cell boundaries zip-up or depolymerize in an angle-dependent manner, as predicted by the model. Finally, we show microtubule alignment responds to cell shape in diverse epithelia.This work was supported by grant BB/K00056X/1 from the UK Biotechnology, Biological Sciences Research Council. Gurdon Institute core funding was provided by the Wellcome Trust (092096) and Cancer Research UK (C6946/A14492). L.C. was supported by the Royal Society of Edinburgh/Scottish Government