O enfrentamento da violência de gênero pelo olhar de mulheres sob cuidados da Terapia Ocupacional

A violência contra a mulher é qualquer ato de violência de gênero que resulte ou possa resultar em danos ou sofrimentos físicos, sexuais ou mentais para as mulheres, sendo um problema social construído ao longo dos séculos, estruturado no modelo social patriarcal e tradicional, onde o machismo se destaca. Este estudo foi realizado em 5 encontros com um grupo de 10 mulheres, acompanhadas pelo Centro de Referência Especializado de Assistência Social (CREAS) Ilka Brandão, na cidade de Belém-PA. Trata-se de uma pesquisa qualitativa, do tipo cartográfica. Os achados da pesquisa nos permitem confirmar acerca da abrangência que os impactos da violência de gênero assumem sobre as histórias de vida das mulheres e suas expressividades. A Terapia Ocupacional, diante deste fenômeno, busca ofertar suporte pela escuta, acolhimento e facilitação da expressão

Minimal Symptom Expression' in Patients With Acetylcholine Receptor Antibody-Positive Refractory Generalized Myasthenia Gravis Treated With Eculizumab

The efficacy and tolerability of eculizumab were assessed in REGAIN, a 26-week, phase 3, randomized, double-blind, placebo-controlled study in anti-acetylcholine receptor antibody-positive (AChR+) refractory generalized myasthenia gravis (gMG), and its open-label extension

ESTUDO ELETROCARDIOGRÁFICO E CLÍNICO DE FELINOS SUBMETIDOS À ANESTESIA DISSOCIATIVA ASSOCIADA AO CLORIDRATO DE TRAMADOL, COM OU SEM FORNECIMENTO DE OXIGÊNIOTERAPIA VIA MÁSCARA

The association of tiletamine with zolazepam (T/Z) is commonly used in dissociative anesthesia in household pets. This combination induces short-duration somatic analgesia, loss of voluntary movements and myorelaxation caused by the benzodiazepin, with stimulation of the ardiovascular system and maintenance of protective reflexes. Due to the large use of this association in elective neutering of felines and its anesthetic properties, we chose to monitorize and identify electrocardiographic (ECG) and clinical changes during the anesthetic procedure, with and without oxygen supplementation. For this study, 20 female felines were recruited. All animals were young adults, healthy, no specific breed. The subjects underwent clinical, laboratorial and electrocardiographic evaluations prior to anesthesia. Tramadol hydrochloride was given as Preanesthetic medication followed by anesthesia with T/Z. The felines were randomly assigned to either Group 1 (n=10), in which subjects received oxygen supplementation through mask during the anesthetic procedure, or Group 2 (n=10), in which subjects were not supplemented with oxygen. Heart and respiratory rates, systolic blood pressure, rectal temperature and pulse oxymetry were monitored in all subjects from both groups. We also obtained recordings of the ECG tracing and derivations for each animal which were posteriorly evaluated and interpreted. The results showed significant differences between the groups in respiratory rate (G1 = 26,8 +/- 2,1 and G2= 38,5+/- 3,2) and pulse oxymetry (G1= 97,3 +/- 2,4% and G2 = 91,2 +/- 1,1%). We also observed on the ECG recordings development of periods of intermittent right branch blockage and S-T elevation in both groups. We therefore concluded that the ECG recordings were identical in both groups despite oxygenotherapy; however, we observed an improvement in the clinical parameters in animals who received oxygen supplementation via mask

A novel insight on SARS-CoV-2 S-derived fragments in the control of the host immunity

Abstract Despite all efforts to combat the pandemic of COVID-19, we are still living with high numbers of infected persons, an overburdened health care system, and the lack of an effective and definitive treatment. Understanding the pathophysiology of the disease is crucial for the development of new technologies and therapies for the best clinical management of patients. Since the manipulation of the whole virus requires a structure with an adequate level of biosafety, the development of alternative technologies, such as the synthesis of peptides from viral proteins, is a possible solution to circumvent this problem. In addition, the use and validation of animal models is of extreme importance to screen new drugs and to compress the organism's response to the disease. Peptides derived from recombinant S protein from SARS-CoV-2 were synthesized and validated by in silico, in vitro and in vivo methodologies. Macrophages and neutrophils were challenged with the peptides and the production of inflammatory mediators and activation profile were evaluated. These peptides were also inoculated into the swim bladder of transgenic zebrafish larvae at 6 days post fertilization (dpf) to mimic the inflammatory process triggered by the virus, which was evaluated by confocal microscopy. In addition, toxicity and oxidative stress assays were also developed. In silico and molecular dynamics assays revealed that the peptides bind to the ACE2 receptor stably and interact with receptors and adhesion molecules, such as MHC and TCR, from humans and zebrafish. Macrophages stimulated with one of the peptides showed increased production of NO, TNF-α and CXCL2. Inoculation of the peptides in zebrafish larvae triggered an inflammatory process marked by macrophage recruitment and increased mortality, as well as histopathological changes, similarly to what is observed in individuals with COVID-19. The use of peptides is a valuable alternative for the study of host immune response in the context of COVID-19. The use of zebrafish as an animal model also proved to be appropriate and effective in evaluating the inflammatory process, comparable to humans

Neotropical freshwater fisheries : A dataset of occurrence and abundance of freshwater fishes in the Neotropics

The Neotropical region hosts 4225 freshwater fish species, ranking first among the world's most diverse regions for freshwater fishes. Our NEOTROPICAL FRESHWATER FISHES data set is the first to produce a large-scale Neotropical freshwater fish inventory, covering the entire Neotropical region from Mexico and the Caribbean in the north to the southern limits in Argentina, Paraguay, Chile, and Uruguay. We compiled 185,787 distribution records, with unique georeferenced coordinates, for the 4225 species, represented by occurrence and abundance data. The number of species for the most numerous orders are as follows: Characiformes (1289), Siluriformes (1384), Cichliformes (354), Cyprinodontiformes (245), and Gymnotiformes (135). The most recorded species was the characid Astyanax fasciatus (4696 records). We registered 116,802 distribution records for native species, compared to 1802 distribution records for nonnative species. The main aim of the NEOTROPICAL FRESHWATER FISHES data set was to make these occurrence and abundance data accessible for international researchers to develop ecological and macroecological studies, from local to regional scales, with focal fish species, families, or orders. We anticipate that the NEOTROPICAL FRESHWATER FISHES data set will be valuable for studies on a wide range of ecological processes, such as trophic cascades, fishery pressure, the effects of habitat loss and fragmentation, and the impacts of species invasion and climate change. There are no copyright restrictions on the data, and please cite this data paper when using the data in publications

Brazilian Flora 2020: Leveraging the power of a collaborative scientific network

International audienceThe shortage of reliable primary taxonomic data limits the description of biological taxa and the understanding of biodiversity patterns and processes, complicating biogeographical, ecological, and evolutionary studies. This deficit creates a significant taxonomic impediment to biodiversity research and conservation planning. The taxonomic impediment and the biodiversity crisis are widely recognized, highlighting the urgent need for reliable taxonomic data. Over the past decade, numerous countries worldwide have devoted considerable effort to Target 1 of the Global Strategy for Plant Conservation (GSPC), which called for the preparation of a working list of all known plant species by 2010 and an online world Flora by 2020. Brazil is a megadiverse country, home to more of the world's known plant species than any other country. Despite that, Flora Brasiliensis, concluded in 1906, was the last comprehensive treatment of the Brazilian flora. The lack of accurate estimates of the number of species of algae, fungi, and plants occurring in Brazil contributes to the prevailing taxonomic impediment and delays progress towards the GSPC targets. Over the past 12 years, a legion of taxonomists motivated to meet Target 1 of the GSPC, worked together to gather and integrate knowledge on the algal, plant, and fungal diversity of Brazil. Overall, a team of about 980 taxonomists joined efforts in a highly collaborative project that used cybertaxonomy to prepare an updated Flora of Brazil, showing the power of scientific collaboration to reach ambitious goals. This paper presents an overview of the Brazilian Flora 2020 and provides taxonomic and spatial updates on the algae, fungi, and plants found in one of the world's most biodiverse countries. We further identify collection gaps and summarize future goals that extend beyond 2020. Our results show that Brazil is home to 46,975 native species of algae, fungi, and plants, of which 19,669 are endemic to the country. The data compiled to date suggests that the Atlantic Rainforest might be the most diverse Brazilian domain for all plant groups except gymnosperms, which are most diverse in the Amazon. However, scientific knowledge of Brazilian diversity is still unequally distributed, with the Atlantic Rainforest and the Cerrado being the most intensively sampled and studied biomes in the country. In times of “scientific reductionism”, with botanical and mycological sciences suffering pervasive depreciation in recent decades, the first online Flora of Brazil 2020 significantly enhanced the quality and quantity of taxonomic data available for algae, fungi, and plants from Brazil. This project also made all the information freely available online, providing a firm foundation for future research and for the management, conservation, and sustainable use of the Brazilian funga and flora