Meio ambiente e arena pública: governança ambiental e suas implicações para as políticas públicas

This is the final version of the article. Available from the publisher via the DOI in this record.O quadro institucional da sociedade contemporânea se alterou, uma vez que a fronteira entre a esfera do público e do privado se torna cada vez mais fluida, isto é, o Estado não é mais o único ator a regular o comportamento dos agentes sociais, muito menos a desenvolver questões sobre o que é público. Isso não é diferente quando se trata de questões ambientais. Nesse contexto, este artigo tem o objetivo de apontar uma abordagem sobre as ações públicas para o meio ambiente com base no exame das experiências do banco de dados do programa Gestão Pública e Cidadania e das ações recentes da Rede Amigos da Amazônia. Concluiu-se que tal abordagem deve considerar pelo menos três elementos: transversalidade, uma vez que os impactos ambientais envolvem diferentes áreas do conhecimento e da ação governamental; não neutralidade, considerando que a compreensão dos impactos ambientais passa por uma negociação na arena pública; governança, haja vista que a temática ambiental requer a articulação e o relacionamento de diferentes atores

Drug-Induced Anaphylaxis: An Update on Epidemiology and Risk Factors

Drug hypersensitivity is one of the most frequent causes of anaphylaxis, particularly in adults and in hospitalized patients. Drug-induced anaphylaxis (DIA) is also associated with more severe outcomes than other anaphylaxis triggers, and drugs are responsible for the majority of deaths due to anaphylaxis. We here review the current knowledge on the incidence, prevalence, drugs involved, mortality, and mortality risk factors for DIA. The incidence of both anaphylaxis and DIA seems to be increasing worldwide. Antibiotics and analgesics are the most frequently reported triggers of DIA. However, the importance of other drug groups should be taken into account, especially in particular settings (e.g., peri-operative and oncology). The identification of risk factors, geographical variables, and drugs associated with higher risk for DIA may improve the outcomes of this entity.info:eu-repo/semantics/publishedVersio

The association between fungi exposure and hypersensitivity pneumonitis: a systematic review

A systematic review of published studies focused on the association between hypersensitivity pneumonitis (HP) and fungi exposure was conducted on PubMed, following PRISMA guidelines for systematic reviews. A total of 14 studies met the inclusion criteria but only 6 of these studies were eligible, as the remaining 8 represented case reports that were separately included for further discussion. HP is an interstitial lung disease (ILD) characterized by a hypersensitization response to inhalable antigens and represents 1.5% to 12% of all ILD in the European population. Several fungi species that populate the indoor environment have been associated with the incidence of HP upon cumulative exposure, with Penicillium spp and Aspergillus spp being the fungi species most frequently associated with the onset of disease. Although some studies have shown that avoiding exposure to causative HP fungi tends to improve patients’ symptoms, other studies were unable to identify the source of sensitization. More microbial exposure studies are needed to properly estimate the risk of HP development in the built environment.This study has been performed in the framework of the EXALAR 21 project, which was funded by the European Regional Development Fund (FEDER), through the Competitiveness and Internationalization Operational Program, and by national funding from the Foundation for Science and Technology (FCT) under the reference info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC/GES-AMB/30193/2017/PT (POCI-01-0145-FEDER-030193, 02/SAICT/2017—Project n° 30193)

Cutaneous Phaeohyphomycosis Caused by Alternaria alternata Unresponsive to Itraconazole Treatment

Cutaneous alternariosis is an opportunistic infection that has been described mainly in patients treated with corticosteroids. We report a case of dermal alternariosis occurring in a woman treated with corticosteroids after a neurosurgery that was unresponsive to itraconazole. Treatment with intravenous voriconazole was initiated, followed by oral protocol, with marked improvement of the lesions

Giant pilomatricoma in a patient with tuberous sclerosis, both diagnosed in the adult life.

Pilomatricoma is a relatively common benign skin neoplasm originating from the hair follicle matrix cells. β-Catenin is a subunit of the cadherin protein complex. It acts as an intracellular signal transducer that influences cell differentiation and proliferation. This protein was recently involved in the formation of hair follicle-related tumours, including pilomatricomas. Tuberous sclerosis (TS) is an inherited neurocutaneous disease, which is characterised by pleomorphic features involving many organs, hamartomas in multiple organ systems and by the fact that it is usually diagnosed early in life. We reported a case of a Caucasian patient with TS and a giant pilomatricoma, both diagnosed in the adult life

Performance of care for end‐of‐life cancer patients in Tuscany: The interplay between place of care, aggressive treatments, opioids, and place of death. A retrospective cohort study

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