ANTIVIRAL AND IMMUNOSTIMULATORY POTENTIAL OF FLUORINE CONTAINING TRIAZOLES

The problem of finding effective antiviral drugs caused high morbidity and wide spread of viral infections. The purpose of this study was to investigate of antyherpetic activity fluorinated nucleoside G8 and G9 compounds (2-N-substituted-4-tosyl-5polyfluoroalkyl-1,2,3-triazole) in in vivo models and determine their immunomodulatory potential. Shown significant inhibition of virus reproduction under the influence of the compounds at concentrations of 0.4 and 0.5 mg/kg, which was more effective of acyclovir. Protection ratio amounted to 80%. Increasing level of IFN-γ and IL-2 in serum of animals, indicated available immunomodulatory effect fluorinated nucleoside compounds. Our studies indicated that there is antiherpetic, immunomodulatory activity of fluorine containing triazole and there is need to in-depth study of the mechanisms of this process

The Size Ellect on the Infrared Spectra of Condensed Media Under Conditions of ID, 2D and 3D Dielectric Confinement

A general expression for the dielectric loss spectrum of an absorbing composite medium was obtained from a Maxwell-Garnett general equation. This expression was simplified for the cases of one, two and three dimensional dielectric confinement in both ordered and disordered thin layers, rods (wires) and spheres of absorbing medium which are considered as mesoparticles or mesoscopic molecules. This theoretical approach was verified experimentally using high purity organic liquids with strong absorption bands in the infrared range. Three organic liquids, namely benzene, chloroform and carbon disulphide, were measured in various dielectric confinement configurations using Fourier Transform Infrared (FTIR) spectroscopy with a Grazing Angle attachment GATRTM. A significant shift of the resonant absorption band of liquid mesoparticles was observed for various dielectric confinement geometries which is in good agreement with theoretical predictions. Possible applications of this work include investigations of industrial smoke, toxic aerosols and liquid droplets

A first record of Isistius plutodus in the north-eastern Atlantic

One specimen of the largetooth cookiecutter shark Isistius plutodus was caught in the northeastern Atlantic at 43°58' N; 28°32' W. This is the first record of this rare species in the northeastern Atlantic and the northernmost point of its known distribution

Ways of increasing the multichannel dopler signal filter efficiency

The two ways of management of the peak-frequency characteristic of the doppler multichannel filter for the purpose of combining its resection zone with a passive hindrance spectrum have been offered

Anton Chekhov and Robert Koch Cheek to Cheek : a Proteomic Study

Five different letters and post cards as well as the shirt worn by Anton Chekhov on his death bed, stored in the State Literary-Memorial Museum-Reserve A. P. Chekhov Melikhovo (nearby Moscow), have been analyzed by applying EVA (an ethyl vinyl acetate foil studded with crushed strong anion and cation exchangers and with C8 resins) diskettes to these surfaces. Three different eluates (under acidic and basic conditions and with acetonitrile) were analyzed by high resolution mass spectrometry. The environmental microbiota present on samples and the Mycobacterium tuberculosis strain were described by a meta-proteomics approach. Eight identified M. tuberculosis proteins confirmed the presence of the bacterium and the cause of Chekhov's death, in addition to several sequenced peptides belonging to other bacterial species. The human plasma proteins and human keratins, detected on a tiny blood spot on the shirt, demonstrated the power of the combined approach