159 research outputs found
AN ML BASED DIGITAL FORENSICS SOFTWARE FOR TRIAGE ANALYSIS THROUGH FACE RECOGNITION
Since the past few years, the complexity and heterogeneity of digital crimes has increased exponentially, which has made the digital evidence & digital forensics paramount for both criminal investigation and civil litigation cases. Some of the routine digital forensic analysis tasks are cumbersome and can increase the number of pending cases especially when there is a shortage of domain experts. While the work is not very complex, the sheer scale can be taxing. With the current scenarios and future predictions, crimes are only going to become more complex and the precedent of collecting and examining digital evidence is only going to increase. In this research, we propose an ML based Digital Forensics Software for Triage Analysis called Synthetic Forensic Omnituens (SynFO) that can automate evidence acquisition, extraction of relevant files, perform automated triage analysis and generate a basic report for the analyst. Results of this research show a promising future for automation with the help of Machine Learning
Ferromagnetism and giant magnetoresistance in the rare earth fullerides Eu6-xSrxC60
We have studied crystal structure, magnetism and electric transport
properties of a europium fulleride Eu6C60 and its Sr-substituted compounds,
Eu6-xSrxC60. They have a bcc structure, which is an isostructure of other M6C60
(M represents an alkali atom or an alkaline earth atom). Magnetic measurements
revealed that magnetic moment is ascribed to the divalent europium atom with S
= 7/2 spin, and a ferromagnetic transition was observed at TC = 10 - 14 K. In
Eu6C60, we also confirm the ferromagnetic transition by heat capacity
measurement. The striking feature in Eu6-xSrxC60} is very large negative
magnetoresistance at low temperature; the resistivity ratio \rho(H = 9
T)/\rho(H = 0 T) reaches almost 10^{-3} at 1 K in Eu6C60. Such large
magnetoresistance is the manifestation of a strong pi-f interaction between
conduction carriers on C60 and 4f electrons of Eu.Comment: 5 pages, 4 figure
Raman Scattering Study of Ba-doped C60 with t1g States
Raman spectra are reported for Ba doped fullerides, BaxC60(x=3,4,and 6). The
lowest frequency Hg modes split into five components for Ba4C60 and Ba6C60 even
at room temperature, allowing us a quantitative analysis based on the
electron-phonon couping theory. For the superconducting Ba4C60, the density of
states at the Fermi energy was derived as 7 eV-1, while the total value of
electron-phonon coupling \lambda was found to be 1.0, which is comparable to
that of K3C60. The tangential Ag(2) mode, which is known as a sensitive probe
for the degree of charge transfer on C60 molecule, shows a remarkable shift
depending on the Ba concentration, being roughly consistent with the full
charge transfer from Ba to C60. An effect of hybridization between Ba and C60
\pi orbitals is also discussed.Comment: 15 pages, 6 figures submitted to Phys. Rev. B (December 1,1998
SERIES: eHealth in primary care. Part 1: Concepts, conditions and challenges.
Primary care is challenged to provide high quality, accessible and affordable care for an increasingly ageing, complex, and multimorbid population. To counter these challenges, primary care professionals need to take up new and innovative practices, including eHealth. eHealth applications hold the promise to overcome some difficulties encountered in the care of people with complex medical and social needs in primary care. However, many unanswered questions regarding (cost) effectiveness, integration with healthcare, and acceptability to patients, caregivers, and professionals remain to be elucidated. What conditions need to be met? What challenges need to be overcome? What downsides must be dealt with? This first paper in a series on eHealth in primary care introduces basic concepts and examines opportunities for the uptake of eHealth in primary care. We illustrate that although the potential of eHealth in primary care is high, several conditions need to be met to ensure that safe and high-quality eHealth is developed for and implemented in primary care. eHealth research needs to be optimized; ensuring evidence-based eHealth is available. Blended care, i.e. combining face-to-face care with remote options, personalized to the individual patient should be considered. Stakeholders need to be involved in the development and implementation of eHealth via co-creation processes, and design should be mindful of vulnerable groups and eHealth illiteracy. Furthermore, a global perspective on eHealth should be adopted, and eHealth ethics, patients' safety and privacy considered.Published versio
Zinc intake, status and indices of cognitive function in adults and children: a systematic review and meta-analysis
In developing countries, deficiencies of micronutrients are thought to have a major impact on child development; however, a consensus on the specific relationship between dietary zinc intake and cognitive function remains elusive. The aim of this systematic review was to examine the relationship between zinc intake, status and indices of cognitive function in children and adults. A systematic literature search was conducted using EMBASE, MEDLINE and Cochrane Library databases from inception to March 2014. Included studies were those that supplied zinc as supplements or measured dietary zinc intake. A meta-analysis of the extracted data was performed where sufficient data were available. Of all of the potentially relevant papers, 18 studies met the inclusion criteria, 12 of which were randomised controlled trials (RCTs; 11 in children and 1 in adults) and 6 were observational studies (2 in children and 4 in adults). Nine of the 18 studies reported a positive association between zinc intake or status with one or more measure of cognitive function. Meta-analysis of data from the adult’s studies was not possible because of limited number of studies. A meta-analysis of data from the six RCTs conducted in children revealed that there was no significant overall effect of zinc intake on any indices of cognitive function: intelligence, standard mean difference of <0.001 (95% confidence interval (CI) –0.12, 0.13) P=0.95; executive function, standard mean difference of 0.08 (95% CI, –0.06, 022) P=0.26; and motor skills standard mean difference of 0.11 (95% CI –0.17, 0.39) P=0.43. Heterogeneity in the study designs was a major limitation, hence only a small number (n=6) of studies could be included in the meta-analyses. Meta-analysis failed to show a significant effect of zinc supplementation on cognitive functioning in children though, taken as a whole, there were some small indicators of improvement on aspects of executive function and motor development following supplementation but high-quality RCTs are necessary to investigate this further
Assessment of the proportion of neonates and children in low and middle income countries with access to a healthcare facility: A systematic review
<p>Abstract</p> <p>Background</p> <p>Comprehensive antenatal, perinatal and early postnatal care has the potential to significantly reduce the 3.58 million neonatal deaths that occur annually worldwide. This paper systematically reviews data on the proportion of neonates and children < 5 years of age that have access to health facilities in low and middle income countries. Gaps in available data by WHO region are identified, and an agenda for future research and advocacy is proposed.</p> <p>Methods</p> <p>For this paper, "utilization" was used as a proxy for "access" to a healthcare facility, and the term "facility" was used for any clinic or hospital outside of a person's home staffed by a "medical professional". A systematic literature search was conducted for published studies of children up to 5 years of age that included the neonatal age group with an illness or illness symptoms in which health facility utilization was quantified. In addition, information from available Demographic and Health Surveys (DHS) was extracted.</p> <p>Results</p> <p>The initial broad search yielded 2,239 articles, of which 14 presented relevant data. From the community-based neonatal studies conducted in the Southeast Asia region with the goal of enhancing care-seeking for neonates with sepsis, the 10-48% of sick neonates in the studies' control arms utilized a healthcare facility. Data from cross-sectional surveys involving young children indicate that 12 to 86% utilizing healthcare facilities when sick. From the DHS surveys, a global median of 58.1% of infants < 6 months were taken to a facility for symptoms of ARI.</p> <p>Conclusions</p> <p>There is a scarcity of data regarding the access to facility-based care for sick neonates/young children in many areas of the world; it was not possible to generalize an overall number of neonates or young children that utilize a healthcare facility when showing signs and symptoms of illness. The estimate ranges were broad, and there was a paucity of data from some regions. It is imperative that researchers, advocates, and policy makers join together to better understand the factors affecting health care utilization/access for newborns in different settings and what the barriers are that prevent children from being taken to a facility in a timely manner.</p
Free Cysteine Modulates the Conformation of Human C/EBP Homologous Protein
The C/EBP Homologous Protein (CHOP) is a nuclear protein that is integral to the unfolded protein response culminating from endoplasmic reticulum stress. Previously, CHOP was shown to comprise extensive disordered regions and to self-associate in solution. In the current study, the intrinsically disordered nature of this protein was characterized further by comprehensive in silico analyses. Using circular dichroism, differential scanning calorimetry and nuclear magnetic resonance, we investigated the global conformation and secondary structure of CHOP and demonstrated, for the first time, that conformational changes in this protein can be induced by the free amino acid l-cysteine. Addition of l-cysteine caused a significant dose-dependent decrease in the protein helicity – dropping from 69.1% to 23.8% in the presence of 1 mM of l-cysteine – and a sequential transition to a more disordered state, unlike that caused by thermal denaturation. Furthermore, the presence of small amounts of free amino acid (80 µM, an 8∶1 cysteine∶CHOP ratio) during CHOP thermal denaturation altered the molecular mechanism of its melting process, leading to a complex, multi-step transition. On the other hand, high levels (4 mM) of free l-cysteine seemed to cause a complete loss of rigid cooperatively melting structure. These results suggested a potential regulatory function of l-cysteine which may lead to changes in global conformation of CHOP in response to the cellular redox state and/or endoplasmic reticulum stress
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