Effect of Pelvic Floor Muscle Exercise Training Protocol For Pregnant Woman during 3rd Trimester on Labor Duration

Background: Pelvic floor muscles training during pregnancy can produce strong and well controlled muscles that will facilitate labor progress and outcomes. The aim of this quasi-experimental non equivalent control study was to assess the effect of pelvic floor muscle exercise training protocol for pregnant woman during 3rd trimester on labor duration. Sample: A total of 100 pregnant women in 3rd trimester were recruited for this study. Research design: A convenience sample was used & divided into two groups (study & control groups) 50 each; the study group who received pelvic floor muscle training exercise and control group who received standard routine care at El-Manial University Hospital, Cairo University, Egypt. Each group was assigned randomly to the line of management. Tools: Structured interviewing tool, pelvic floor muscles strength assessment, antenatal follow up checklist, partograph. Results: a statistically significantly difference between the study and control groups in relation to duration of 1st, 2nd and 3rd stage of labor. Conclusion: pelvic floor muscle training exercise can be useful to decrease duration of labor. Recommendation: Pelvic floor muscle training exercise should be an essential part of prenatal care. The nurse should be an educator and counselor for mothers during prenatal care. Keywords: pelvic floor muscle training exercise, 3rd trimester of pregnancy, labor duratio

Securing the Skies: Cybersecurity Strategies for Smart City Cloud using Various Algorithams

As smart cities continue to evolve, their reliance on cloud computing technologies becomes increasingly apparent, enabling the seamless integration of data-driven services and urban functionalities. However, this transformation also raises concerns about the security of the vast and interconnected cloud infrastructures that underpin these cities' operations. This paper explores the critical intersection of cloud computing and cybersecurity within the context of smart cities. This research is dealing with challenges posed by the rapid expansion of smart city initiatives and their reliance on cloud-based solutions. It investigates the vulnerabilities that emerge from this technological convergence, emphasizing the potential risks to data privacy, urban services, and citizen well-being. The abstract presents a comprehensive overview of the evolving threat landscape that smart cities face in the realm of cloud computing. To address these challenges, the abstract highlights the importance of proactive cybersecurity strategies tailored specifically to the unique needs of smart cities. It underscores the significance of adopting a multi-layered approach that encompasses robust encryption protocols, intrusion detection systems, threat intelligence sharing, and collaborative efforts among stakeholders. Drawing insights from existing research and real-world case studies, the abstract showcases innovative solutions that leverage advanced technologies like artificial intelligence and blockchain to fortify the security posture of smart city cloud infrastructures. It explores the role of data governance, user authentication, and anomaly detection in creating a resilient cybersecurity framework that safeguards critical urban systems

rac-Ethyl 6-hy­droxy-6-methyl-3-oxo-4-phenyl-1,3,4,5,6,7-hexa­hydro­benzo[c][1,2]oxazole-5-carboxyl­ate

In the title compound, C17H19NO5, the cyclo­hexene ring is in a half-chair conformation and the isoxazole ring in an envelope conformation with the N atom as the flap. The C atoms in the 4- and 6-positions are of the same absolute configuration, whereas the C atom in the 5-position is of the opposite configuration, i.e. (4S*,5R*,6S*). The methyl fragment of the eth­oxy­carbonyl group at position 5 is disordered over two sets of sites in a 0.60:0.40 ratio. The crystal packing displays inter­molecular N—H⋯O and O—H⋯O hydrogen bonds

Radiosurgery and fractionated stereotactic body radiotherapy for patients with lung oligometastases

Background: Patients with oligometastatic disease can potentially be cured by using an ablative therapy for all active lesions. Stereotactic body radiotherapy (SBRT) is a non-invasive treatment option that lately proved to be as effective and safe as surgery in treating lung metastases (LM). However, it is not clear which patients benefit most and what are the most suitable fractionation regimens. The aim of this study was to analyze treatment outcomes after single fraction radiosurgery (SFRS) and fractionated SBRT (fSBRT) in patients with lung oligometastases and identify prognostic clinical features for better survival outcomes. Methods: Fifty-two patients with 94 LM treated with SFRS or fSBRT between 2010 and 2016 were analyzed. The characteristics of primary tumor, LM, treatment, toxicity profiles and outcomes were assessed. Kaplan-Meier and Cox regression analyses were used for estimation of local control (LC), overall survival (OS) and progression-free survival. Results: Ninety-four LM in 52 patients were treated using SFRS/fSBRT with a median of 2 lesions per patient (range: 1-5). The median planning target volume (PTV)-encompassing dose for SFRS was 24 Gy (range: 17-26) compared to 45 Gy (range: 20-60) in 2-12 fractions with fSBRT. The median follow-up time was 21 months (range: 3-68). LC rates at 1 and 2 years for SFSR vs. fSBRT were 89 and 83% vs. 75 and 59%, respectively (p = 0.026). LM treated with SFSR were significantly smaller (p = 0.001). The 1 and 2-year OS rates for all patients were 84 and 71%, respectively. In univariate analysis treatment with SFRS, an interval of ≥12 months between diagnosis of LM and treatment, non-colorectal cancer histology and BED 70% and time to first metastasis ≥12 months. There was no grade 3 acute or late toxicity. Conclusions: Longer time to first metastasis, good KPS and N0 predicted better OS. Good LC and low toxicity rates were achieved after short SBRT schedules

Digoxin net secretory transport in bronchial epithelial cell layers is not exclusively mediated by P-glycoprotein/MDR1

Copyright © 2013 The Authors. Published by Elsevier B.V. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are creditedThe impact of P-glycoprotein (MDR1, ABCB1) on drug disposition in the lungs as well as its presence and activity in in vitro respiratory drug absorption models remain controversial to date. Hence, we characterised MDR1 expression and the bidirectional transport of the common MDR1 probe 3H-digoxin in air-liquid interfaced (ALI) layers of normal human bronchial epithelial (NHBE) cells and of the Calu-3 bronchial epithelial cell line at different passage numbers. Madin-Darby Canine Kidney (MDCKII) cells transfected with the human MDR1 were used as positive controls. 3H-digoxin efflux ratio (ER) was low and highly variable in NHBE layers. In contrast, ER=11.4 or 3.0 was measured in Calu-3 layers at a low or high passage number, respectively. These were, however, in contradiction with increased MDR1 protein levels observed upon passaging. Furthermore, ATP depletion and the two MDR1 inhibitory antibodies MRK16 and UIC2 had no or only a marginal impact on 3H-digoxin net secretory transport in the cell line. Our data do not support an exclusive role of MDR1 in 3H-digoxin apparent efflux in ALI Calu-3 layers and suggest the participation of an ATP-independent carrier. Identification of this transporter might provide a better understanding of drug distribution in the lungs.Peer reviewe

A well-conserved Plasmodium falciparum var gene shows an unusual stage-specific transcript pattern

The var multicopy gene family encodes Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variant antigens, which, through their ability to adhere to a variety of host receptors, are thought to be important virulence factors. The predominant expression of a single cytoadherent PfEMP1 type on an infected red blood cell, and the switching between different PfEMP1 types to evade host protective antibody responses, are processes thought to be controlled at the transcriptional level. Contradictory data have been published on the timing of var gene transcription. Reverse transcription-polymerase chain reaction (RT-PCR) data suggested that transcription of the predominant var gene occurs in the later (pigmented trophozoite) stages, whereas Northern blot data indicated such transcripts only in early (ring) stages. We investigated this discrepancy by Northern blot, with probes covering a diverse var gene repertoire. We confirm that almost all var transcript types were detected only in ring stages. However, one type, the well-conserved varCSA transcript, was present constitutively in different laboratory parasites and does not appear to undergo antigenic variation. Although varCSA has been shown to encode a chondroitin sulphate A (CSA)-binding PfEMP1, we find that the presence of full-length varCSA transcripts does not correlate with the CSA-binding phenotype

Flammability characteristics of chemical treated woven hemp fabric reinforced vinyl ester composites

In the present work, the treatments using sodium hydroxide, flame retardant chemical and combination of both sodium hydroxide and flame retardant changed the physical properties thus reduced the mechanical properties of woven hemp fabric and fabricated composites. However, the treatments increased the fire retardant properties of fabricated composites as indicated by the burning tests, thermogravimetry analyses and limiting oxygen index tests. An assessment based on woods and engineered wood products have shown that the fabricated composites are suitable to be used for building infrastructure materials as an alternative to wood products

Quantum interferometry with three-dimensional geometry

Quantum interferometry uses quantum resources to improve phase estimation with respect to classical methods. Here we propose and theoretically investigate a new quantum interferometric scheme based on three-dimensional waveguide devices. These can be implemented by femtosecond laser waveguide writing, recently adopted for quantum applications. In particular, multiarm interferometers include "tritter" and "quarter" as basic elements, corresponding to the generalization of a beam splitter to a 3- and 4-port splitter, respectively. By injecting Fock states in the input ports of such interferometers, fringe patterns characterized by nonclassical visibilities are expected. This enables outperforming the quantum Fisher information obtained with classical fields in phase estimation. We also discuss the possibility of achieving the simultaneous estimation of more than one optical phase. This approach is expected to open new perspectives to quantum enhanced sensing and metrology performed in integrated photonic.Comment: 7 pages (+4 Supplementary Information), 5 figure