11 research outputs found
Neuroprotective effect of systemic and/or intravitreal rosuvastatin administration in rat glaucoma model.
To evaluate the neuroprotective effect of rosuvastatin, in a rat experimental glaucoma model
The Evaluatıon of Neuroprotectıve Effect of Systemıc And/Or Intravıtreal Rosuvastatın Admınıstratıon In Rat Glaucoma Model
Does Venipuncture Increase Lymphedema by Triggering Inflammation or Infection? An Experimental Rabbit Ear Lymphedema Model Study
Background: Recent guidelines recommend avoiding venipuncture to prevent lymphedema for breast cancer patients. This study investigated whether single or multiple sterile venipuncture procedures develop a systemic inflammation or infection and increase lymphedema in the rabbit ear lymphedema model.Methods and Results: Eighteen New Zealand white female rabbits were included. The right ear lymphedema model was created by surgical procedure; then, rabbits were divided into three randomized groups. Single and multiple venipuncture procedures were applied at least the 60th day after surgery for Group I and II, respectively. Group III was a control group. C-reactive protein (CRP) and procalcitonin (PCT) levels were analyzed to determine inflammation and infection. Ear thickness measurements were applied using a vernier caliper to assess the differences in lymphedema between the ears. All rabbits were euthanized on the 90th day after surgery. Histopathological analysis was performed to evaluate lymphedema by measuring tissue thicknesses. Ear thickness measurements showed that ear lymphedema was developed and maintained with surgical operation in all groups (p 0.05). CRP and PCT levels were below the lower detection levels in all groups. According to the differences of histopathological ear distances, there were significant differences within-groups for all groups (p 0.05).Conclusion: This experimental study demonstrated that single or multiple sterile venipuncture procedures did not trigger infection or inflammation and did not exacerbate ear lymphedema in the rabbit ear lymphedema model
Ratlarda Glokom Modelinde Sistemik ve/veya İntravitreal Rosuvastatin Uygulamasının Retinal Ganglion Hücreleri Üzerine Nöroprotektif Etkisinin Değerlendirilmesi.
Neuroprotective effect of systemic and/or intravitreal rosuvastatin administration in rat glaucoma model
AIM: To evaluate the neuroprotective effect of rosuvastatin, in a rat experimental glaucoma model
Treatment with the soluble guanylate cyclase activator BAY 60–2770 normalizes bladder function in an in vivo rat model of chronic prostatitis
Neuroprotective effect of systemic and/or intravitreal rosuvastatin administration in rat glaucoma model
AIM: To evaluate the neuroprotective effect of rosuvastatin, in a rat
experimental glaucoma model.
METHODS: Ocular hypertension was induced in right eyes of Long-Evans
rats (n=30) by cauterization of three episcleral veins. Left eyes were
defined as controls. Rats were divided into five groups: oral
rosuvastatin, intravitreal rosuvastatin, oral +intravitreal
rosuvastatin, intravitreal sham and glaucoma without intervention. Rats
were sacrificed at day 14. Retinal ganglion cell (RGC) number was
assessed by histopathological analysis. Terminal deoxynucleotidyl
transferase-mediated dUTP-nick end-labeling (TUNEL) staining and the
expression of glial fibrillary acidic protein (GFAP) in RGC layer was
also examined.
RESULTS: A significant intraocular pressure (IOP) elevation was seen
(P=0.002). Elevated IOP resulted in a significant decrease in number of
RGCs in group 5 (70.33 +/- 8.2 cells/mm(2)) when compared with controls
(92.50 +/- 13.72 cells/mm(2); P=0.03). The RGC number in group 1 (92.4
+/- 7.3 cells/mm(2)) was significantly higher than group 5 (P=0.03). The
numbers of RGC in groups 2, 3 (57.3 +/- 8.2 cells/mm(2), 60.5 +/- 12.9
cells/mm(2)) were comparable with that of group 5 (P=0.18 and P=0.31).
The apoptosis rates with TUNEL staining were also parallel to RGC
number. Animals with experimentally induced glaucoma showed an increase
in retinal GFAP immunoreactivity.
CONCLUSION: Decrease in RGC loss and apoptosis suggest the
neuroprotective potential of oral rosuvastatin treatment in a rat model
of ocular hypertension. However intravitreal rosuvastatin showed a
contrary effect and further studies are required
Ultrasound-guided thyroid nodule fine-needle biopsies - comparison of sample adequacy with different sampling techniques, different needle sizes, and with/without onsite cytological analysis
Introduction: The aim of this study was to compare the diagnostic
adequacy of thyroid samples obtained by aspiration or capillary biopsy
techniques, with 22 or 27 gauge needles, and with or without onsite
cytological analysis (OCA).
Material and methods: Four hundred patients with thyroid nodules
underwent ultrasound (US)-guided fine-needle biopsies. Patients were
divided into eight groups according to needle size (22 vs. 27 gauge),
biopsy technique (aspiration vs. capillary), and whether or not OCA was
performed. Sample adequacy rates were calculated for each group and
subgroups and compared using chi-square tests.
Results: When all nodes were evaluated (n = 400), the adequacy rate was
significantly greater with the capillary than with the aspiration
technique (97\% vs. 91.5\%, p = 0.032) and when OCA was than was not
performed (97\% vs. 91.5\%, p = 0.032). When only solid nodules were
evaluated (n = 205) the adequacy rate was also significantly greater
with the capillary than with the aspiration technique (98.9\% vs.
89.7\%, p = 0.008) and when OCA was than was not performed (97.9\% vs.
89.6\%, p = 0.014). In contrast, the adequacy rate was similar for 22
and 27 gauge needles (94.2\% vs. 93.1\%, p = 0.733).
Conclusions: Optimal results were obtained with the capillary technique
and OCA. The capillary technique and OCA should be the preferred
approach in thyroid nodule biopsy, optimising adequacy rates and patient
comfort
Is it easy to clinically distinguish inflammatory arthritis of bacterial origin from monoarthritis attacks of gout disease?
Acute monoarthritis is a common situation in orthopedic emergency where
the patient presents with typical inflamed joint. It is hard to
clinically distinguish inflammatory arthritis of bacterial origin from
monoarthritis attacks of gout disease. If these two situations, which
are the most common causes of acute monoarthritis, are misdiagnosed,
outcomes might be catastrophic and costly. Synovial fluid analysis is
the most reliable method for confirming the diagnosis although it might
not always lead to definitive diagnosis. If there is clinical suspicion
for crystal arthropathy, repeated examinations may provide benefits for
confirming the diagnosis