Every Motion Counts

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Towards FAIR principles for research software

The FAIR Guiding Principles, published in 2016, aim to improve the findability, accessibility, interoperability and reusability of digital research objects for both humans and machines. Until now the FAIR principles have been mostly applied to research data. The ideas behind these principles are, however, also directly relevant to research software. Hence there is a distinct need to explore how the FAIR principles can be applied to software. In this work, we aim to summarize the current status of the debate around FAIR and software, as basis for the development of community-agreed principles for FAIR research software in the future. We discuss what makes software different from data with regard to the application of the FAIR principles, and which desired characteristics of research software go beyond FAIR. Then we present an analysis of where the existing principles can directly be applied to software, where they need to be adapted or reinterpreted, and where the definition of additional principles is required. Here interoperability has proven to be the most challenging principle, calling for particular attention in future discussions. Finally, we outline next steps on the way towards definite FAIR principles for research software

Oral history interview with Eva L. Goble, 2007 Jan. 5

Eva Goble is a native of Jasonville, Indiana and she recounts growing up in the Depression and having to take a break from college due to the Depression. She talks about her work with Indiana Extension, including State Leader of Home Demonstration leaders from 1947 to 1958 and how Twin Pines came to be cooperative houses on campus. She was the Assistant Director of Cooperative Extension on campus until becoming Dean of the School of Home Economics in 1967. She retired in 1972

Oral history interview with Eva L. Goble, 2007 Jan. 12

Eva Goble is a native of Jasonville, Indiana and she recounts growing up in the Depression and having to take a break from college due to the Depression. She talks about her work with Indiana Extension, including State Leader of Home Demonstration leaders from 1947 to 1958 and how Twin Pines came to be cooperative houses on campus. She was the Assistant Director of Cooperative Extension on campus until becoming Dean of the School of Home Economics in 1967. She retired in 1972

A pattern motion study

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Malaria Heat Shock Proteins: Drug Targets that Chaperone other Drug Targets

Ongoing research into the chaperone systems of malaria parasites, and particularly of Plasmodium falciparum, suggests that heat shock proteins (Hsps) could potentially be an excellent class of drug targets. The P. falciparum genome encodes a vast range and large number of chaperones, including 43 Hsp40, six Hsp70, and three Hsp90 proteins (PfHsp40s, PfHsp70s and PfHsp90s), which are involved in a number of fundamental cellular processes including protein folding and assembly, protein translocation, signal transduction and the cellular stress response. Despite the fact that Hsps are relatively conserved across different species, PfHsps do exhibit a considerable number of unique structural and functional features. One PfHsp90 is thought to be sufficiently different to human Hsp90 to allow for selective targeting. PfHsp70s could potentially be used as drug targets in two ways: either by the specific inhibition of Hsp70s by small molecule modulators, as well as disruption of the interactions between Hsp70s and co-chaperones such as the Hsp70/Hsp90 organising protein (Hop) and Hsp40s. Of the many PfHsp40s present in the parasite, there are certain unique or essential members which are considered to have good potential as drug targets. This review critically evaluates the potential of Hsps as malaria drug targets, as well as the use of chaperones as aids in the heterologous expression of other potential malarial drug targets