Uneven progress in reducing exposure to violence at home for New Zealand adolescents 2001–2012: a nationally representative cross‐sectional survey series

Objective: To explore trends, and identify risk factors, that may explain changes in adolescent exposure to family violence over time.Methods: Data for this study was drawn from the Youth 2000 series of cross‐sectional surveys, carried out with New Zealand high school students in 2001, 2007 and 2012. Latent class analysis was used to understand different patterns of exposure to multiple risks for witnessing violence at home among adolescents.Results: Across all time periods, there was no change in witnessing emotional violence and a slight decline in witnessing physical violence at home. However, significant differences were noted between 2001 and 2007, and 2007 and 2012, in the proportion of adolescents who reported witnessing emotional and physical violence. Four latent classes were identified in the study sample; these were characterised by respondents' ethnicity, concerns about family relationships, food security and alcohol consumption. For two groups (characterised by food security, positive relationships and lower exposure to physical violence), there was a reduction in the proportion of respondents who witnessed physical violence but an increase in the proportion who witnessed emotional violence between 2001 and 2012. For the two groups characterised by poorer food security and higher exposure to physical violence, there were no changes in witnessing of physical violence in the home.Implications for public health: In addition to strategies directly aimed at violence, policies are needed to address key predictors of violence exposure such as social disparities, financial stress and alcohol use. These social determinants of health cannot be ignored

Design, synthesis and biological assessment of novel N-substituted 3-(phthalimidin-2-yl)-2,6-dioxopiperidines and 3-substituted 2,6-dioxopiperidines for TNF-α inhibitory activity

Eight novel 2-(2,6-dioxopiperidin-3-yl)phthalimidine EM-12 dithiocarbamates 9 and 10, N-substituted 3-(phthalimidin-2-yl)-2,6-dioxopiperidines 11-14 and 3-substituted 2,6-dioxopiperidines 16 and 18 were synthesized as tumor necrosis factor-α (TNF-α) synthesis inhibitors. Synthesis involved utilization of a novel condensation approach, a one-pot reaction involving addition, iminium rearrangement and elimination, to generate the phthalimidine ring required for the creation of compounds 9-14. Agents were, thereafter, quantitatively assessed for their ability to suppress the synthesis on TNF-α in a lipopolysaccharide (LPS)-challenged mouse macrophage-like cellular screen, utilizing cultured RAW 264.7 cells. Whereas compounds 9, 14 and 16 exhibited potent TNF-α lowering activity, reducing TNF-α by up to 48% at 30 μM, compounds 12, 17 and 18 presented moderate TNF-α inhibitory action. The TNF-α lowering properties of these analogs proved more potent than that of revlimid (3) and thalidomide (1). In particular, N-dithiophthalimidomethyl-3-(phthalimidin-2-yl)-2,6-dioxopiperidine 14 not only possessed the greatest potency of the analogs to reduce TNF-α synthesis, but achieved this with minor cellular toxicity at 30 μM. The pharmacological focus of the presented compounds is towards the development of well-tolerated agents to ameliorate the neuroinflammation, that is, commonly associated with neurodegenerative disorders, epitomized by Alzheimer's disease and Parkinson's disease

Designing a Communication Bridge between Communities: Participatory Design for a Question-Answering AI Agent

How do we design an AI system that is intended to act as a communication bridge between two user communities with different mental models and vocabularies? Skillsync is an interactive environment that engages employers (companies) and training providers (colleges) in a sustained dialogue to help them achieve the goal of building a training proposal that successfully meets the needs of the employers and employees. We used a variation of participatory design to elicit requirements for developing AskJill, a question-answering agent that explains how Skillsync works and thus acts as a communication bridge between company and college users. Our study finds that participatory design was useful in guiding the requirements gathering and eliciting user questions for the development of AskJill. Our results also suggest that the two Skillsync user communities perceived glossary assistance as a key feature that AskJill needs to offer, and they would benefit from such a shared vocabulary

PENGARUH IKLAN TELEVISI TERHADAP KEPUTUSAN PEMBELIAN KECAP ABC (Survei Pada Ibu-ibu Rumah Tangga di Kelurahan Isola Bandung)

Pertumbuhan ekonomi dalam era globalisasi menuntut setiap perusahaan baik yang bergerak dalam bidang industri barang maupun jasa mampu bersaing dengan perusahaan lainnya. Salah satunya adalah industri kecap sebagai penyedap rasa, merupakan peluang yang cukup besar dengan persaingan yang semakin tinggi. Para pemasar bersaing dalam membuat produk kecap, dan mempromosikannya sehingga konsumen dihadapkan pada beberapa jenis kecap dengan merek, harga serta kualitas yang berbeda Banyaknya pesaing dalam industri kecap mengakibatkan penurunan trend future intention dan penurunan awareness konsumen terhadap produk kecap ABC beberapa tahun terakhir. Hal ini mengakibatkan penurunan penjualan terutama di daerah-daerah basis produk pesaingnya, sehingga diduga perlu dilakukan upaya untuk menciptakan awareness melalui implementasi iklan televisi yang terdiri dari Mission, Message, Media yang akan memberi pengaruh terhadap keputusan pembelian kecap ABC dalam jangka waktu yang panjang Bedasarkan uraian di atas, maka diadakan penelitian mengenai pengaruh iklan televisi terhadap keputusan pembelian kecap ABC. Tujuan penelitian ini adalah untuk mengetahui bagaimana tanggapan responden terhadap iklan televisi yang dilaksanakan oleh PT Heinz ABC, untuk mengetahui bagaimana kecenderungan dalam melakukan keputusan pembelian yang dilakukan oleh konsumen, dan untuk mengetahui seberapa besar pengaruh iklan televisi (Mission, Message dan Media) terhadap keputusan pembelian konsumen kecap ABC di Kelurahan Isola Kota Bandung. Manfaat penelitian ini untuk kepentingan akademis yaitu dapat memperluas wawasan ilmu pengetahuan dalam bidang Manajemen Pemasaran khususnya yang menyangkut tentang iklan media televisi (Advertising) kaitannya dengan keputusan pembelian konsumen dan kepentingan praktis yaitu sebagai bahan masukan bagi PT Heinz ABC Objek yang diteliti adalah konsumen kecap ABC di kelurahan Isola. Jumlah sampel yang diambil adalah 105 orang. Metode yang digunakan adalah deskriptif survey dan explanatory survey. Data yang digunakan adalah data primer dan data sekunder yang dikumpulkan melalui observasi, studi kepustakaan, dan angket. Untuk mengukur seberapa besar peranan variabel X terhadap variabel Y digunakan teknik analisis regresi linier sederhana. Berdasarkan penelitian, diketahui thitung 14,983 dan ttabel 1,986 (thitung > ttabel), berarti ada pengaruh positif dari iklan televisi terhadap keputusan pembelian. Koefisien determinasi (r²) sebesar 68,5% menunjukkan tingkat pengaruh iklan televisi terhadap keputusan pembelian termasuk pada kategori tinggi, artinya keputusan pembelian dipengaruhi iklan televisi sebesar 68,5%, sisanya 31,5% dipengaruhi faktor lain, seperti kualitas produk dan harg

Lineament Extraction using Gravity Data in the Citarum Watershed

Lineament is one of the most important features showing subsurface elements or structural weakness such as faults. This study aims to identify subsurface lineament patterns using automatic lineament in Citarum watershed with gravity data. Satellite gravity data were used to generate a sub-surface lineament. Satellite gravity data corrected using Bouguer and terrain correction to obtain a complete Bouguer anomaly value. Butterworth filters were used to separate regional and residual anomaly from the complete Bouguer anomaly value. Residual anomaly gravity data used to analyze sub-surface lineament. Lineament generated using Line module in PCI Geomatica to obtain sub-surface lineament from gravity residual value. The orientations of lineaments and fault lines were created by using rose diagrams. The main trends observed in the lineament map could be recognized in these diagrams, showing a strongly major trend in NW-SE, and the subdominant directions were in N-S. Area with a high density of lineament located at the Southern part of the study area. High-density lineament might be correlated with fractured volcanic rock upstream of the Citarum watershed, meanwhile, low-density lineament is associated with low-density sediment. The high-density fracture might be associated with intensive tectonics and volcanism

ASA Subcommittee recommendations based on the advice of the High School Graduation Rate Goal Advisory Panel

Each year the South Carolina Education Oversight Committee (EOC) establishes objectives regarding its mission to improve the outcomes from our public educational system. One of the EOC’s objectives for 2007-2008 is to “establish a goal for high school graduation to include reporting data for different student groups and the inclusion of fifth year graduates.” The EOC convened an advisory panel to make recommendations regarding the goal and how public policy may be directed to meet the goal. The recommendations from the panel are the basis of this report

The global fatty liver disease Sustainable Development Goal country score for 195 countries and territories

Background and Aims: Fatty liver disease is highly prevalent, resulting in overarching wellbeing and economic costs. Addressing it requires comprehensive and coordinated multisectoral action. We developed a fatty liver disease Sustainable Development Goal (SDG) country score to provide insights into country-level preparedness to address fatty liver disease through a whole-of-society lens. // Approach and Results: We developed 2 fatty liver disease–SDG score sets. The first included 6 indicators (child wasting, child overweight, noncommunicable disease mortality, a universal health coverage service coverage index, health worker density, and education attainment), covering 195 countries and territories between 1990 and 2017. The second included the aforementioned indicators plus an urban green space indicator, covering 60 countries and territories for which 2017 data were available. To develop the fatty liver disease–SDG score, indicators were categorized as “positive” or “negative” and scaled from 0 to 100. Higher scores indicate better preparedness levels. Fatty liver disease–SDG scores varied between countries and territories (n = 195), from 14.6 (95% uncertainty interval: 8.9 to 19.4) in Niger to 93.5 (91.6 to 95.3) in Japan; 18 countries and territories scored > 85. Regionally, the high-income super-region had the highest score at 88.8 (87.3 to 90.1) in 2017, whereas south Asia had the lowest score at 44.1 (42.4 to 45.8). Between 1990 and 2017, the fatty liver disease–SDG score increased in all super-regions, with the greatest increase in south Asia, but decreased in 8 countries and territories. // Conclusions: The fatty liver disease–SDG score provides a strategic advocacy tool at the national and global levels for the liver health field and noncommunicable disease advocates, highlighting the multisectoral collaborations needed to address fatty liver disease, and noncommunicable diseases overall

Adoption of practice guidelines and assessment tools in substance abuse treatment

<p>Abstract</p> <p>Background</p> <p>The gap between research and practice limits utilization of relevant, progressive and empirically validated strategies in substance abuse treatment.</p> <p>Methods</p> <p>Participants included substance abuse treatment programs from the Northeastern United States. Structural equation models were constructed with agency level data to explore two outcome variables: adoption of practice guidelines and assessment tools at two points in time; models also included organizational, staffing and service variables.</p> <p>Results</p> <p>In 1997, managed care involvement and provision of primary care services had the strongest association with increased use of assessment tools, which, along with provision of counseling services, were associated with a greater use of practice guidelines. In 2001, managed care involvement, counseling services and being a stand-alone drug treatment agency were associated with a greater use of assessment tools, which was in turn related to an increase in the use of practice guidelines.</p> <p>Conclusions</p> <p>This study provides managers, clinicians and policy-makers with a framework for understanding factors related to the adoption of new technologies in substance abuse treatment.</p

The Games for Older Adults Active Life (GOAL) Project for People With Mild Cognitive Impairment and Vascular Cognitive Impairment: A Study Protocol for a Randomized Controlled Trial

Background: People living with Mild Cognitive Impairment (MCI) and Vascular Cognitive Impairment (VCI) are persons who do not fulfill a diagnosis of dementia, but who have a high risk of progressing to a dementia disorder. The most recent guidelines to counteract cognitive decline in MCI/VCI subjects suggest a multidimensional and multi-domain interventions combining cognitive, physical, and social activities. The purpose of this study is to test an innovative service that provides a multi-dimensional tele-rehabilitation program through a user-friendly web application. The latter has been developed through a participatory design involving MCI specialists, patients, and their caregivers. Particularly, the proposed tele-rehabilitation program includes cognitive, physical, and caregiver-supported social activities. The goal is to promote and preserve an active life style and counteract cognitive decline in people living with MCI/VCI.Methods:The study is a randomized controlled trial. Sixty subjects will be randomly assigned to the experimental group, who will receive the tele-rehabilitation program, or the control group, who will not receive any treatment. The trial protocol comprises three steps of assessment for the experimental group: at the baseline (T_0), after tele-rehabilitation program (T_1) and at follow-up after 12-months (T_2). Differently, the control group will be assessed twice: at the baseline and at 12-months follow-up. Both the experimental and the control group will be assessed with a multidimensional evaluation battery, including cognitive functioning, behavioral, functional, and quality of life measures. The tele-rehabilitation program lasts 8 weeks and includes cognitive exercises 3 days a week, physical activities 2 days a week, and social activities once a week. In addition, group will be given an actigraph (GENEActiv, Activisinghts Ltd., Cambridgshire, UK) to track physical and sleep activity.Discussion:Results of this study will inform on the efficacy of the proposed tele-rehabilitation to prevent or delay further cognitive decline in MCI/VCI subjects. The expected outcome is to counteract cognitive decline and improve both physical functioning and quality of life.Ethics and Dissemination:The study is approved by the Local Ethics Committee and registered in https://clinicaltrials.gov (NCT03383549). Dissemination will include submission to a peer-reviewed journal, patients, and healthcare magazines and congress presentations.Trial Registration: ClinicalTrials.gov ID: NCT03383549 (registration date: 26/dec/2017)Trial Funding: Bando FAS Salute 2014 Regione ToscanaVersion Identifier: ver 5—16/11/201