30 research outputs found
Low birth weight and small for gestational age are associated with complications of childhood and adolescence obesity: systematic review and meta-analysis
In recent decades, the incidence of type 2 diabetes (T2D) has increased dramatically in children and adolescents, posing a real public health problem. Beyond unhealthy diets and sedentary lifestyles, growing evidence suggests that some perinatal factors, such as low birth weight (LBW), are associated with higher risk of T2D in adulthood. In this regard, it remains unclear whether the increased risk is already present in childhood and adolescence. We conducted a systematic review and meta-analysis to clarify the association of LBW or being small for gestational age (SGA) with insulin resistance in childhood and adolescence. The systematic review resulted in 28 individual studies, and those with the same outcome were included within two random-effects meta-analyses. Compared with children or adolescents born with adequate size for gestational age, those SGA had 2.33-fold higher risk of T2D (95% confidence interval [CI]: 1.05â5.17). Furthermore, LBW and being SGA were associated with 0.20 higher mean homeostasis model assessment of insulin resistance (HOMA-IR) values (95% CI: 0.02â0.38). Given the high prevalence of preterm babies, from a population perspective, these results may be of great importance as they point to the existence of a potentially vulnerable subgroup of children and adolescents that could benefit from screening tests and early preventive strategies
Using Kinect to classify Parkinson's disease stages related to severity of gait impairment
Background: Parkinsonâs Disease (PD) is a chronic neurodegenerative disease associated with motor problems such
as gait impairment. Different systems based on 3D cameras, accelerometers or gyroscopes have been used in related
works in order to study gait disturbances in PD. Kinect has also been used to build these kinds of systems, but
contradictory results have been reported: some works conclude that Kinect does not provide an accurate method of
measuring gait kinematics variables, but others, on the contrary, report good accuracy results.
Methods: In this work, we have built a Kinect-based system that can distinguish between different PD stages, and
have performed a clinical study with 30 patients suffering from PD belonging to three groups: early PD patients
without axial impairment, more evolved PD patients with higher gait impairment but without Freezing of Gait (FoG),
and patients with advanced PD and FoG. Those patients were recorded by two Kinect devices when they were
walking in a hospital corridor. The datasets obtained from the Kinect were preprocessed, 115 features identified, some
methods were applied to select the relevant features (correlation based feature selection, information gain, and
consistency subset evaluation), and different classification methods (decision trees, Bayesian networks, neural
networks and K-nearest neighbours classifiers) were evaluated with the goal of finding the most accurate method for
PD stage classification.
Results: The classifier that provided the best results is a particular case of a Bayesian Network classifier (similar to a
NaĂŻve Bayesian classifier) built from a set of 7 relevant features selected by the correlation-based on feature selection
method. The accuracy obtained for that classifier using 10-fold cross validation is 93.40%. The relevant features are
related to left shin angles, left humerus angles, frontal and lateral bents, left forearm angles and the number of steps
during spin.
Conclusions: In this paper, it is shown that using Kinect is adequate to build a inexpensive and comfortable system
that classifies PD into three different stages related to FoG. Compared to the results of previous works, the obtained
accuracy (93.40%) can be considered high. The relevant features for the classifier are: a) movement and position of the
left arm, b) trunk position for slightly displaced walking sequences, and c) left shin angle, for straight walking
sequences. However, we have obtained a better accuracy (96.23%) for a classifier that only uses features extracted
from slightly displaced walking steps and spin walking steps. Finally, the obtained set of relevant features may lead to
new rehabilitation therapies for PD patients with gait problems
Changes in Anxiety and Depression Traits Induced by Energy Restriction: Predictive Value of the Baseline Status
Current evidence proposes diet quality as a modifiable risk factor for mental or emotional impairments. However, additional studies are required to investigate the effect of dietary patterns and weight loss on improving psychological symptoms. The aim of this investigation was to evaluate the effect of energy-restriction, prescribed to overweight and obese participants, on anxiety and depression symptoms, as well as the potential predictive value of some baseline psychological features on weight loss. Overweight and obese participants (n = 305) were randomly assigned for 16 weeks to two hypocaloric diets with different macronutrient distribution: a moderately high-protein (MHP) diet and a low-fat (LF) diet. Anthropometrical, clinical, psychological, and lifestyle characteristics were assessed at baseline and at the end of the intervention. The nutritional intervention evidenced that weight loss has a beneficial effect on trait anxiety score in women (ÎČ = 0.24, p = 0.03), depression score in all population (ÎČ = 0.15, p = 0.02), particularly in women (ÎČ = 0.22, p = 0.03) and in subjects who followed the LF diet (ÎČ = 0.22, p = 0.04). Moreover, weight loss could be predicted by anxiety status at baseline, mainly in women and in those who were prescribed a LF diet. This trial suggests that weight loss triggers an improvement in psychological traits, and that anxiety symptoms could predict those volunteers that benefit most from a balanced calorie-restricted intervention, which will contribute to individualized precision nutrition
Birth weight and blood lipid levels in Spanish adolescents: Influence of selected APOE, APOC3 and PPARgamma2 gene polymorphisms. The AVENA Study
Es reproducciĂłn del documento publicado en http://dx.doi.org/10.1186/1471-2350-9-98Background: There is increasing evidence indicating that genes involved in certain metabolic processes of cardiovascular diseases may be of particular influence in people with low body weight at birth. We examined whether the apolipoprotein (APO) E, APOC3 and the peroxisome proliferator-activated receptor-gamma-2 (PPAR gamma 2) polymorphisms influence the association between low birth weight and blood lipid levels in healthy adolescents aged 13-18.5 years.
Methods: A cross-sectional study of 502 Spanish adolescents born at term was conducted. Total (TC) and high density lipoprotein cholesterol (HDLc), triglycerides (TG), apolipoprotein (apo) A and B, and lipoprotein(a) [ Lp(a)] were measured. Low density lipoprotein cholesterol (LDLc), TC-HDLc, TC/HDLc and apoB/apoA were calculated. Results: Low birth weight was associated with higher levels of TC, LDLc, apoB, Lp(a), TC-HDLc, TC/HDLc and apoB/apoA in males with the APOE epsilon 3 epsilon 4 genotype, whereas in females, it was associated with lower HDLc and higher TG levels. In males with the APOC3 S1/S2 genotype, low birth weight was associated with lower apoA and higher Lp(a), yet this association was not observed in females. There were no associations between low birth weight and blood lipids in any of the PPAR gamma 2 genotypes.
Conclusion: The results indicate that low birth weight has a deleterious influence on lipid profile particularly in adolescents with the APOE epsilon 3/epsilon 4 genotype. These findings suggest that intrauterine environment interact with the genetic background affecting the lipid profile in later life.Instituto de Salud Carlos III (FIS PI021830), the Spanish Ministry of Health, FEDER-FSE funds FIS n 00/0015, CSD grants 05/UPB32/0, 109/UPB31/03 and 13/UPB20/04, Ministerio de EducaciĂłn (AP-2004-2745; EX2007-1124
Associations between eating speed, diet quality, adiposity, and cardiometabolic risk factors
Objective: To assess the associations between eating speed, adiposity, cardiometabolic risk factors, and diet quality in a cohort of Spanish preschool-children. Study design: A cross-sectional study in 1371 preschool age children (49% girls; mean age, 4.8 ± 1.0 years) from the Childhood Obesity Risk Assessment Longitudinal Study (CORALS) cohort was conducted. After exclusions, 956 participants were included in the analyses. The eating speed was estimated by summing the total minutes used in each of the 3 main meals and then categorized into slow, moderate, or fast. Multiple linear and logistic regression models were fitted to assess the ÎČ-coefficient, or OR and 95% CI, between eating speed and body mass index, waist circumference, fat mass index (FMI), blood pressure, fasting plasma glucose, and lipid profile. Results: Compared with participants in the slow-eating category, those in the fast-eating category had a higher prevalence risk of overweight/obesity (OR, 2.9; 95% CI, 1.8-4.4; P < .01); larger waist circumference (ÎČ, 2.6 cm; 95% CI, 1.5-3.8 cm); and greater FMI (ÎČ, 0.3 kg/m2; 95% CI, 0.1-0.5 kg/m2), systolic blood pressure (ÎČ, 2.8 mmHg; 95% CI, 0.6-4.9 mmHg), and fasting plasma glucose levels (ÎČ, 2.7 mg/dL, 95% CI, 1.2-4.2 mg/dL) but lower adherence to the Mediterranean diet (ÎČ, â0.5 points; 95% CI, â0.9 to â0.1 points). Conclusions: Eating fast is associated with higher adiposity, certain cardiometabolic risk factors, and lower adherence to a Mediterranean diet. Further long-term and interventional studies are warranted to confirm these associations
Longitudinal association of dietary acid load with kidney function decline in an older adult population with metabolic syndrome
Background: Diets high in acid load may contribute to kidney function impairment. This study aimed to investigate the association between dietary acid load and 1-year changes in glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (UACR). Methods: Older adults with overweight/obesity and metabolic syndrome (mean age 65 ± 5 years, 48% women) from the PREDIMED-Plus study who had available data on eGFR (n = 5,874) or UACR (n = 3,639) at baseline and after 1 year of follow-up were included in this prospective analysis. Dietary acid load was estimated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) at baseline from a food frequency questionnaire. Linear and logistic regression models were fitted to evaluate the associations between baseline tertiles of dietary acid load and kidney function outcomes. One year-changes in eGFR and UACR were set as the primary outcomes. We secondarily assessed â„ 10% eGFR decline or â„10% UACR increase. Results: After multiple adjustments, individuals in the highest tertile of PRAL or NEAP showed higher one-year changes in eGFR (PRAL, ÎČ: â0.64 ml/min/1.73 m2; 95% CI: â1.21 to â0.08 and NEAP, ÎČ: â0.56 ml/min/1.73 m2; 95% CI: â1.13 to 0.01) compared to those in the lowest category. No associations with changes in UACR were found. Participants with higher levels of PRAL and NEAP had significantly higher odds of developing â„10% eGFR decline (PRAL, OR: 1.28; 95% CI: 1.07â1.54 and NEAP, OR: 1.24; 95% CI: 1.03â1.50) and â„10 % UACR increase (PRAL, OR: 1.23; 95% CI: 1.04â1.46) compared to individuals with lower dietary acid load. Conclusions: Higher PRAL and NEAP were associated with worse kidney function after 1 year of follow-up as measured by eGFR and UACR markers in an older Spanish population with overweight/obesity and metabolic syndrome
One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvenciĂłn con DIeta MEDiterrĂĄnea-Plus (PREDIMED-Plus) trial
Choline and betaine intakes have been related to cardiovascular health. We aimed to explore the relation between 1-y changes in dietary intake of choline or betaine and 1-y changes in cardiometabolic and renal function traits within the frame of the PREDIMED (PREvenciĂłn con DIeta MEDiterrĂĄnea)-Plus trial. We used baseline and 1-y follow-up data from 5613 participants (48.2% female and 51.8% male; mean ± SD age: 65.01 ± 4.91 y) to assess cardiometabolic traits, and 3367 participants to assess renal function, of the Spanish PREDIMED-Plus trial. Participants met â„3 criteria of metabolic syndrome and had overweight or obesity [BMI (in kg/m 2) â„27 and â€40]. These criteria were similar to those of the PREDIMED parent study. Dietary intakes of choline and betaine were estimated from the FFQ. The greatest 1-y increase in dietary choline or betaine intake (quartile 4) was associated with improved serum glucose concentrations (â3.39 and â2.72 mg/dL for choline and betaine, respectively) and HbA1c levels (â0.10% for quartile 4 of either choline or betaine intake increase). Other significant changes associated with the greatest increase in choline or betaine intake were reduced body weight (â2.93 and â2.78 kg, respectively), BMI (â1.05 and â0.99, respectively), waist circumference (â3.37 and â3.26 cm, respectively), total cholesterol (â4.74 and â4.52 mg/dL, respectively), and LDL cholesterol (â4.30 and â4.16 mg/dL, respectively). Urine creatinine was reduced in quartile 4 of 1-y increase in choline or betaine intake (â5.42 and â5.74 mg/dL, respectively). Increases in dietary choline or betaine intakes were longitudinally related to improvements in cardiometabolic parameters. Markers of renal function were also slightly improved, and they require further investigation. This trial was registered at as ISRCTN89898870
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Dietary αâLinolenic Acid, Marine Ïâ3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvenciĂłn con DIeta MEDiterrĂĄnea (PREDIMED) Study
Background: Epidemiological evidence suggests a cardioprotective role of αâlinolenic acid (ALA), a plantâderived Ïâ3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine Ïâ3 fatty acids (longâchain nâ3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0.7% of total energy) at baseline was related to allâcause and cardiovascular disease mortality. We also examined the effect of meeting the society's recommendation for longâchain nâ3 polyunsaturated fatty acids (â„500 mg/day). Methods and Results: We longitudinally evaluated 7202 participants in the PREvenciĂłn con DIeta MEDiterrĂĄnea (PREDIMED) trial. Multivariableâadjusted Cox regression models were fitted to estimate hazard ratios. ALA intake correlated to walnut consumption (r=0.94). During a 5.9ây followâup, 431 deaths occurred (104 cardiovascular disease, 55 coronary heart disease, 32 sudden cardiac death, 25 stroke). The hazard ratios for meeting ALA recommendation (n=1615, 22.4%) were 0.72 (95% CI 0.56â0.92) for allâcause mortality and 0.95 (95% CI 0.58â1.57) for fatal cardiovascular disease. The hazard ratios for meeting the recommendation for longâchain nâ3 polyunsaturated fatty acids (n=5452, 75.7%) were 0.84 (95% CI 0.67â1.05) for allâcause mortality, 0.61 (95% CI 0.39â0.96) for fatal cardiovascular disease, 0.54 (95% CI 0.29â0.99) for fatal coronary heart disease, and 0.49 (95% CI 0.22â1.01) for sudden cardiac death. The highest reduction in allâcause mortality occurred in participants meeting both recommendations (hazard ratio 0.63 [95% CI 0.45â0.87]). Conclusions: In participants without prior cardiovascular disease and high fish consumption, dietary ALA, supplied mainly by walnuts and olive oil, relates inversely to allâcause mortality, whereas protection from cardiac mortality is limited to fishâderived longâchain nâ3 polyunsaturated fatty acids. Clinical Trial Registration URL: http://www.Controlled-trials.com/. Unique identifier: ISRCTN35739639
Revista de psicodidĂĄctica
Resumen basado en el de la publicaciĂłn. Resumen en castellano e inglĂ©sSe presenta el Cuestionario de Autoconcepto FĂsico (CAF) de nueva creaciĂłn, tanto en lengua castellana como en euskera, cuyas propiedades psicomĂ©tricas le hacen adecuado para su aplicaciĂłn a partir de la preadolescencia. Se trata, al mismo tiempo, de clarificar interrogantes teĂłricos sobre cuestiones tales como las dimensiones del autoconcepto fĂsico, la relaciĂłn entre el autoconcepto fĂsico y el desarrollo personal, la prĂĄctica deportiva o la ausencia de trastornos de conducta alimentaria, las caracterĂsticas de una adecuada intervenciĂłn educativa para promover el autoconcepto fĂsico.PaĂs VascoUniversidad PĂșblica de Navarra. Biblioteca; Campus de ArrosadĂa; 31006 Pamplona; Tel. +34948169060; Fax +34948169069;ES
Low birth weight and small for gestational age are associated with complications of childhood and adolescence obesity: systematic review and meta-analysis
In recent decades, the incidence of type 2 diabetes (T2D) has increased dramatically in children and adolescents, posing a real public health problem. Beyond unhealthy diets and sedentary lifestyles, growing evidence suggests that some perinatal factors, such as low birth weight (LBW), are associated with higher risk of T2D in adulthood. In this regard, it remains unclear whether the increased risk is already present in childhood and adolescence. We conducted a systematic review and meta-analysis to clarify the association of LBW or being small for gestational age (SGA) with insulin resistance in childhood and adolescence. The systematic review resulted in 28 individual studies, and those with the same outcome were included within two random-effects meta-analyses. Compared with children or adolescents born with adequate size for gestational age, those SGA had 2.33-fold higher risk of T2D (95% confidence interval [CI]: 1.05â5.17). Furthermore, LBW and being SGA were associated with 0.20 higher mean homeostasis model assessment of insulin resistance (HOMA-IR) values (95% CI: 0.02â0.38). Given the high prevalence of preterm babies, from a population perspective, these results may be of great importance as they point to the existence of a potentially vulnerable subgroup of children and adolescents that could benefit from screening tests and early preventive strategies