Brownian ratchet in a thermal bath driven by Coulomb friction

The rectification of unbiased fluctuations, also known as the ratchet effect, is normally obtained under statistical non-equilibrium conditions. Here we propose a new ratchet mechanism where a thermal bath solicits the random rotation of an asymmetric wheel, which is also subject to Coulomb friction due to solid-on-solid contacts. Numerical simulations and analytical calculations demonstrate a net drift induced by friction. If the thermal bath is replaced by a granular gas, the well known granular ratchet effect also intervenes, becoming dominant at high collision rates. For our chosen wheel shape the granular effect acts in the opposite direction with respect to the friction-induced torque, resulting in the inversion of the ratchet direction as the collision rate increases. We have realized a new granular ratchet experiment where both these ratchet effects are observed, as well as the predicted inversion at their crossover. Our discovery paves the way to the realization of micro and sub-micrometer Brownian motors in an equilibrium fluid, based purely upon nano-friction.Comment: main paper: 4 pages and 4 figures; supplemental material joined at the end of the paper; a movie of the experiment can be viewed http://www.youtube.com/watch?v=aHrdY4BC71k ; all the material has been submitted for publication [new version with substantial changes in the order of the presentation of the results; differences with previous works have been put in evidence

Ta/CoFeB/MgO analysis for low power nanomagnetic devices

The requirement of high memory bandwidth for next-generation computing systems moved the attention to the development of devices that can combine storage and logic capabilities. Domain wall-based spintronic devices intrinsically combine both these requirements making them suitable both for non-volatile storage and computation. CoPt and CoNi were the technology drivers of perpendicular Nano Magnetic Logic devices (pNML), but for power constraints and depinning fields, novel CoFeBMgO layers appear more promis- ing. In this paper, we investigate the Ta2CoFeB1MgO2Ta3 stack at the simulation and experimental level, to show its potential for the next generation of magnetic logic devices. The micromagnetic simulations are used to support the experiments. We focus, first, at the experimental level measuring the switching field distribution of patterned magnetic islands, Ms via VSM and the domain wall speed on magnetic nanowires. Then, at the simulation level, we focus on the magnetostatic analysis of magnetic islands quantifying the stray field that can be achieved with different layout topologies. Our results show that the achieved coupling is strong enough to realize logic computation with magnetic islands, moving a step forward in the direction of low power perpendicularly magnetized logic devices

Ga+ Ion Irradiation-Induced Tuning of Artificial Pinning Sites to Control Domain Wall Motion

Domain-wall-based devices are considered one of the candidates for the next generation of storage memories and nanomagnetic logic devices due to their unique properties, such as nonvolatility, scalability, and low power consumption. Field or current-driven domain walls require a regular and controlled motion along the track in which they are stored in order to maintain the information integrity during operation. However, their dynamics can vary along the track due to film inhomogeneities, roughness of the edges, and thermal fluctuations. Consequently, the final position of the domain walls may be difficult to predict, making difficult the development of memory and logic applications. In this paper, we demonstrate how Ga+ ion irradiation can be used to locally modify the material properties of the Ta/ CoFeB/MgO thin film, creating regions in which the domain wall can be trapped, namely motion barriers. The aim is to push the domain wall to overcome thin-film inhomogeneities effects, while stopping its motion at artificially defined positions corresponding to the irradiated regions. Increasing the driving force strength, the domain wall can escape, allowing the shifting between consecutive irradiated regions. In this way, the correct positioning of the domain walls after the motion is ensured. The study shows that the driving force strength, namely current density or magnetic field amplitude, needed to overcome the irradiated regions depends on the ion dose. These results show a reliable approach for domain wall manipulation, enabling a precise control of the domain wall position along a track with synchronous motion

Patterns of novel alleles and genotype/phenotype correlations resulting from the analysis of 108 previously undetected mutations in patients affected by neurofibromatosis type I

Neurofibromatosis type I, a genetic disorder due to mutations in the NF1 gene, is characterized by a high mutation rate (about 50% of the cases are de novo) but, with the exception of whole gene deletions associated with a more severe phenotype, no specific hotspots and few solid genotype/phenotype correlations. After retrospectively re-evaluating all NF1 gene variants found in the diagnostic activity, we studied 108 patients affected by neurofibromatosis type I who harbored mutations that had not been previously reported in the international databases, with the aim of analyzing their type and distribution along the gene and of correlating them with the phenotypic features of the affected patients. Out of the 108 previously unreported variants, 14 were inherited by one of the affected parents and 94 were de novo. Twenty-nine (26.9%) mutations were of uncertain significance, whereas 79 (73.2%) were predicted as pathogenic or probably pathogenic. No differential distribution in the exons or in the protein domains was observed and no statistically significant genotype/phenotype correlation was found, confirming previous evidences

Melorheostosis and Osteopoikilosis Clinical and Molecular Description of an Italian Case Series

Melorheostosis (MEL) is an uncommon, sclerosing disease, characterised by hyperostosis of long bones, resembling the flowing of candle wax. The disease is sporadic and the pathogenesis is still poorly understood. Occasionally, the same family can include individuals with MEL and Osteopoikilosis (OPK), a disease characterised by multiple round foci of increased bone density. LEMD3 gene mutations are related to OPK and Buschke\u2013Ollendorff Syndrome, a genetic condition in which an association between MEL, OPK and skin lesions is observed. In rare cases, LEMD3 mutations and recently mosaic MAP2K1 gene mutations have been correlated to MEL suggesting that somatic mosaicism could be causative of the disease. In this study, we described the clinical, radiological and molecular findings of 19 individuals with MEL and 8 with OPK and compared the results to the medical literature. The molecular analyses of this case series corroborate the available data in the medical literature, indicating that LEMD3 germline mutations are not a major cause of isolated MEL and reporting five further cases of OPK caused by LEMD3 germline mutations