Schelles Multiples Sequenz Alignment

Sequencing technologies are continuously improving and provide access to anincreasing amount of data. This gives rise to many opportunities to gather new insightsabout the sequenced organisms. However, handling such volumes of data is a challenge onits own and established, alignment-based, methods for sequence comparison are reachingtheir capacities. The alternative,alignment-freemethods scale better to large datasetsand are especially useful for phylogeny reconstruction. But their effectiveness comes withthe disadvantage of loosing information about the underlying alignment structure (Vinga,2014). In this thesis, the approach ofanchor alignmentsis implemented. Anchor align-ments have already shown good results inphylonium(Klötzl and Haubold, 2019) foralignment-freedistance estimation. The goal of this thesis is to make the underlyingalignment accessible and to evaluate the results against alignment-based methods.The resulting programparis faster than classical alignment-based approaches. The align-ments are accurate on very closely related genomes that are currently collected duringpangenomic outbreaks. However, as the sequences become more divergent, the accuracystarts to drop quickly

Between Agency and Constraint: Towards an Understanding of {Sexual} Identity Content Development in Context

How do we become the people that we are? In his dissertation, titled “Beyond Static Factors: Introducing An Approach for Studying the Situated Development of {Sexual} Identity Content in Interactions” Ole Gmelin explores the challenges faced by sexual minority individuals in developing adaptive sexual identities. One of the key contributions of this dissertation is to highlight the tension between individual agency and societal norms in identity exploration. Individuals draw on cultural models of “ways of being” to make meaning of their experiences, and this occurs within everyday social interactions. To gain a deeper insight into how social and cultural contexts shape the emergence of adaptive (sexual) identities, it is essential to understand the situated mechanisms that contribute to identity formation. However, within (developmental) Psychology cultural and social environments are predominantly studied in terms of abstract and decontextualized variables in developmental and social psychology. The aim of the dissertation was to examine the concrete actions and behaviors through which cultural and social environments shape the emergence of sexual identities in emerging adults’ everyday conversations. To allow for the study of how identity content is formed in the context of everyday interactions, the dissertation introduces Iterative Micro-Identity Content Analysis (IMICA). Drawing on this new methodological approach, the dissertation was able to highlight not only how individuals explore personal identities, but also how emerging adults jointly negotiate the meanings of social identities when talking about sex

What Is Real about “Real Time” Anyway? A Proposal for A Pluralistic Approach to Studying Identity Processes across Different Timescales

Recently, there has been a growing emphasis on the fact that an understanding of identity development requires the study of real-time identity. But what exactly constitutes ‘real-time identity’? In this manuscript, we highlight that definitions of real time are often fuzzy, which poses a threat to this research field. We discuss two conceptual issues of research on ‘real-time identity’ that we believe require further clarification. The first is that ‘real-time identity’ is often conflated with ‘micro-level identity’. The second is that ‘micro-level identity’ is pitted against ‘macro-level identity’. We attempt to bring clarification to the above issues by drawing attention to three conceptual points: Firstly, we stress that ‘real-time’ simply refers to “the actual time during which something takes place“. Secondly, researchers can study static characteristics of identity phenomena in real time or they can study dynamics of change and development in real time. Thirdly, we draw attention to the fact that the terms ‘micro-level’ and ‘macro-level’ represent two ends of a time-scale continuum. We describe these points in depth and summarize our clarifications as a taxonomy for authors interested in studying ‘real-time identity’, which promises to support theoretical and empirical integration between different approaches to identity

What Is Real about “Real Time” Anyway? A Proposal for A Pluralistic Approach to Studying Identity Processes across Different Timescales

Recently, there has been a growing emphasis on the fact that an understanding of identity development requires the study of real-time identity. But what exactly constitutes ‘real-time identity’? In this manuscript, we highlight that definitions of real time are often fuzzy, which poses a threat to this research field. We discuss two conceptual issues of research on ‘real-time identity’ that we believe require further clarification. The first is that ‘real-time identity’ is often conflated with ‘micro-level identity’. The second is that ‘micro-level identity’ is pitted against ‘macro-level identity’. We attempt to bring clarification to the above issues by drawing attention to three conceptual points: Firstly, we stress that ‘real-time’ simply refers to “the actual time during which something takes place“. Secondly, researchers can study static characteristics of identity phenomena in real time or they can study dynamics of change and development in real time. Thirdly, we draw attention to the fact that the terms ‘micro-level’ and ‘macro-level’ represent two ends of a time-scale continuum. We describe these points in depth and summarize our clarifications as a taxonomy for authors interested in studying ‘real-time identity’, which promises to support theoretical and empirical integration between different approaches to identity

Absolute accuracy in membrane-based ac nanocalorimetry

To achieve accurate results in nanocalorimetry a detailed analysis and understanding of the behavior of the calorimetric system is required. There are especially two system-related aspects that should be taken in consideration: the properties of the empty cell and the effect of the thermal link between sample and cell. Here we study these two aspects for a membrane-based system where heater and thermometer are both in good contact with each other and the center of the membrane. Practical, analytical expressions for describing the frequency dependence of heat capacity, thermal conductance, and temperature oscillation of the system are formulated and compared with measurements and numerical simulations. We finally discuss the experimental conditions for an optimal working frequency, where high resolution and good absolute accuracy are combined

Iterative Micro-Identity Content Analysis:Studying Identity Development within and across Real-Time Interactions

Identity development occurs in the context of real-time interactions. However, existing research on interactions has focused on identity processes and little is known about identity content development within interactions. We define real-time identity as claims about selves, formulated in the service of an interactional “social business.” The aim of this methodological paper is to introduce Iterative Micro-Content Analysis (IMICA) as an approach to studying the changes and consistencies in real-time identity content. We outline four key principles of IMICA and offer a step by step guide to its analytic stages. We provide two worked examples for illustration: a video-recorded conversation between two young women on the topic of “love and desire,” and audio-recorded speed-dating conversations between young same-sex attracted men. The worked examples demonstrate how IMICA can be used to study how identity claims change within a single interaction as well as across multiple interactions. We argue that IMICA’s empirical insights into the concrete mechanisms through which social interactions shape identities are of both theoretical and practical relevance. We discuss how IMICA may allow for a micro-level operationalization of macro-level concepts (e.g., exploration or identity centrality), outline how it may be combined with quantitative analyses, and discuss its limitations

Die Chronik der Kinderklinik an der Lachnerstrasse - "Lachnerklinik"

Die arbeit gibt einen Überblick über die Enstehung einer der ersten Kinderkliniken in München und über die Entstehung der Kinderheilkund