The influence of shocks on star formation in the OMC1 Ridge

Observations are presented of the OMC1 Ridge (a narrow band of molecular gas containing high-mass embedded sources), in the transitions CN N = 2 - 1, 13CO J = 2 - 1 and 13S J = 5 - 4. Variations in velocities and line widths indicate that three distinct regions are present in the area mapped, and that at least one of these is rotating. The resulting shocks when these fragments collided will have compressed the gas to a density nH2~107-8cm-3, sufficient to trigger collapse and to explain the presence of high-mass stars at the edges of the cloud fragments, rather than in their cores. These observational results support theoretical predictions of the importance of collisions in star formation

New detections of isotopic molecular absorption lines: a low ¹²C:¹³C ratio in nearby gas

Molecular absorption line observations towards the background source Sgr B2 `M' are presented. Previous observations have shown that there are ~9 foreground clouds of moderate density along this line of sight, which produce absorption lines that are well spaced in velocity. In two of these clouds, first detections have now been made of the rare isotopomers 12CS, HN13C, HC15N and HC18O+. For a feature at lsr velocities of -4 to +18km s-1, the isotopic ratio 12C:13C has been estimated, from the relative intensities of 12CS and 13CS J=1-0 lines, and also by comparing the strength of the 13CS line with that of C34S J=1-0 observed previously. A convergent solution for the two methods is found if 12CS is optically thick but the isotopomer lines are optically thin. In this case 12C:13C is 24±11, which is surprisingly low if the gas lies near the Sun, as indicated by its velocity. However, it has been suggested that parts of this feature may in fact arise in hot gas close to the Sgr B2 cloud, where a low isotope ratio is expected. If this region of the line is excluded, the 12C:13C ratio for the remaining lsr velocities of +11 to +18kms-1 is only slightly changed, with a value of 22±13. This is the true carbon isotope ratio in some nearby gas, if effects such as peculiar velocities and isotopic fractionation are unimportant. The value found here is well below the local average of ~60-70 in the solar neighbourhood, which suggests that some of the nearby absorbing gas has been recently isotopically enriched by stellar ejecta. This moderate density absorbing gas is then more likely to be material left over after star-formation, rather than a pre-star-for

Neutrino Zero Modes on Electroweak Strings

Zero modes of massive standard model fermions have been found on electroweak Z-strings. A zero mode solution for a massless left-handed neutrino is also known, but was thought to be non-normalizable. Here we show that although this mode is not discretely normalizable, it is delta-function normalizable and the correct interpretation of this solution is within the framework of the continuum spectrum. We also analyze an extension of the standard model including right-handed neutrinos in which neutrinos have Dirac masses, arising from a Yukawa coupling to the usual SU(2) Higgs doublet, and right-handed Majorana masses. The Majorana mass terms are taken to be spatially homogeneous and are presumed to arise from the vacuum expectation value of some field acquired in a phase transition well above the electroweak phase transition. The resulting zero energy equations have a discrete zero mode.Comment: 5 pages, 1 figures, version to appear in Phys. Rev.

Use of synthetic polymers and biopolymers for soil stabilization in agricultural, construction, and military applications

Three relatively new applications for controlling wind and water erosion using polyacrylamide copolymers arc described that take advantage of their ability to stabilize and add structure to soil. In the first application, low concentrations of anionic, high purity polyacrylamide (PAM) eliminates sediment in runoff water by more than 90% when added to irrigation water at 10 ppm, or at a rate of 1 to 2 kg ha-1 per irrigation. Lab-furrow tests were utilized to characterize the role of molecular weight. charge, and ion concentrations in applying PAM during irrigation. In the second application, PAM is applied at construction sites and road cuts at rates of 22.5 kg ha -2 (tenfold higher rates than in irrigation control) resulting in reduction in sediment runoff by 60-85% during (simulated) heavy rains. Finally, a formulation of PAM mixed with aluminum chlorohydrate and cross-linked poly(acrylic acid) superabsorbent at a ratio of (6:1:1) has been applied to create helicopter landing pads that minimize dust clouds during helicopter operation. This formulation was specifically developed to minimize dust clouds during landing of helicopters in fine, arid soils such as those potentially encountered in the Middle East. A biodegradable alternative to PAM, acid-hydrolyzed cellulose microfibrils, was tested in lab-scale furrows and was less effective than PAM at similar concentrations, but show promises. Microfibrils reduce sediment run-off in lab-furrow tests by 88% when applied at eight- to tenfold the concentration of PAM

COVID-19 and emerging viral infections: The case for interferon lambda

With the first reports on coronavirus disease 2019 (COVID-19), which is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the scientific community working in the field of type III IFNs (IFN-λ) realized that this class of IFNs could play an important role in this and other emerging viral infections. In this Viewpoint, we present our opinion on the benefits and potential limitations of using IFN-λ to prevent, limit, and treat these dangerous viral infections

Programmable antivirals targeting critical conserved viral RNA secondary structures from influenza A virus and SARS-CoV-2

Influenza A virus’s (IAV’s) frequent genetic changes challenge vaccine strategies and engender resistance to current drugs. We sought to identify conserved and essential RNA secondary structures within IAV’s genome that are predicted to have greater constraints on mutation in response to therapeutic targeting. We identified and genetically validated an RNA structure (packaging stem–loop 2 (PSL2)) that mediates in vitro packaging and in vivo disease and is conserved across all known IAV isolates. A PSL2-targeting locked nucleic acid (LNA), administered 3 d after, or 14 d before, a lethal IAV inoculum provided 100% survival in mice, led to the development of strong immunity to rechallenge with a tenfold lethal inoculum, evaded attempts to select for resistance and retained full potency against neuraminidase inhibitor-resistant virus. Use of an analogous approach to target SARS-CoV-2, prophylactic administration of LNAs specific for highly conserved RNA structures in the viral genome, protected hamsters from efficient transmission of the SARS-CoV-2 USA_WA1/2020 variant. These findings highlight the potential applicability of this approach to any virus of interest via a process we term ‘programmable antivirals’, with implications for antiviral prophylaxis and post-exposure therapy

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

Heavy Quarks and Heavy Quarkonia as Tests of Thermalization

We present here a brief summary of new results on heavy quarks and heavy quarkonia from the PHENIX experiment as presented at the "Quark Gluon Plasma Thermalization" Workshop in Vienna, Austria in August 2005, directly following the International Quark Matter Conference in Hungary.Comment: 8 pages, 5 figures, Quark Gluon Plasma Thermalization Workshop (Vienna August 2005) Proceeding

Proximity effect at superconducting Sn-Bi2Se3 interface

We have investigated the conductance spectra of Sn-Bi2Se3 interface junctions down to 250 mK and in different magnetic fields. A number of conductance anomalies were observed below the superconducting transition temperature of Sn, including a small gap different from that of Sn, and a zero-bias conductance peak growing up at lower temperatures. We discussed the possible origins of the smaller gap and the zero-bias conductance peak. These phenomena support that a proximity-effect-induced chiral superconducting phase is formed at the interface between the superconducting Sn and the strong spin-orbit coupling material Bi2Se3.Comment: 7 pages, 8 figure

Centrality Dependence of the High p_T Charged Hadron Suppression in Au+Au collisions at sqrt(s_NN) = 130 GeV

PHENIX has measured the centrality dependence of charged hadron p_T spectra from central Au+Au collisions at sqrt(s_NN)=130 GeV. The truncated mean p_T decreases with centrality for p_T > 2 GeV/c, indicating an apparent reduction of the contribution from hard scattering to high p_T hadron production. For central collisions the yield at high p_T is shown to be suppressed compared to binary nucleon-nucleon collision scaling of p+p data. This suppression is monotonically increasing with centrality, but most of the change occurs below 30% centrality, i.e. for collisions with less than about 140 participating nucleons. The observed p_T and centrality dependence is consistent with the particle production predicted by models including hard scattering and subsequent energy loss of the scattered partons in the dense matter created in the collisions.Comment: 7 pages text, LaTeX, 6 figures, 2 tables, 307 authors, resubmitted to Phys. Lett. B. Revised to address referee concerns. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are publicly available at http://www.phenix.bnl.gov/phenix/WWW/run/phenix/papers.htm