Use of rating systems in the process towards sustainable construction

Since the large scale industrialization occurred, the profit oriented human activity has led to a constantly growing environmental degradation. Nowadays, that the actual severity of the problem in hand is impossible to ignore and the spectrum of the future consequences emerges in its full extent, several actions towards the adaptation of sustainability principles in the most problematic sectors of human activity are undertaken. One of these sectors is building sector, incorporating the production, transport, use and replacement of building materials, the use of the building itself (energy consumption for lighting, ventilation, heating and cooling, water consumption etc), the reuse of the building or its materials, the demolition of the building and the disposal of the demolition products. The energy consumed in operating buildings serves as indication of the building sector’s contribution to the total environmental aggravation induced by human activity. According to (OECD, 2003), in the European OECD countries, the building sector consumes the highest amount of energy (40%) in comparison to the transport (22%) and industry sectors (38%). Given the fact that the afore-mentioned quantities include the energy amounts consumed only for the operation of the building, while other processes – unbreakably bonded to construction – such as manufacture and transport of building materials, are not cocalculated, an estimation regarding the impact of the building sector on the environment can be drawn.COST, European Science Foundatio

European overview of sustainable policies and approaches in COST C25 member countries

The implementation of the principles and methods towards a Sustainable Construction varies across different countries in Europe. In some countries, the sustainability of the construction sector has been effectively taken into consideration over the last years, while in other its implementation is at an initial stage. Many reasons may be pointed out for this situation. Different countries have different understandings of what is entailed in Sustainable Construction. Different cultural and educational backgrounds, along with different priorities in each country, are also contributing for the lack of a common European approach. General frameworks, aiming to cover every aspect of Sustainable Construction and to provide a consistent and integrated approach, such as Agenda 21 for Sustainable Construction, gave a major advance in the search for a common approach for the construction sector. However, general agreed methodologies and tools to make this common approach operational are still missing.European Science Foundation - COST Action C2

Lysosomes in iron metabolism, ageing and apoptosis

The lysosomal compartment is essential for a variety of cellular functions, including the normal turnover of most long-lived proteins and all organelles. The compartment consists of numerous acidic vesicles (pH ∼4 to 5) that constantly fuse and divide. It receives a large number of hydrolases (∼50) from the trans-Golgi network, and substrates from both the cells’ outside (heterophagy) and inside (autophagy). Many macromolecules contain iron that gives rise to an iron-rich environment in lysosomes that recently have degraded such macromolecules. Iron-rich lysosomes are sensitive to oxidative stress, while ‘resting’ lysosomes, which have not recently participated in autophagic events, are not. The magnitude of oxidative stress determines the degree of lysosomal destabilization and, consequently, whether arrested growth, reparative autophagy, apoptosis, or necrosis will follow. Heterophagy is the first step in the process by which immunocompetent cells modify antigens and produce antibodies, while exocytosis of lysosomal enzymes may promote tumor invasion, angiogenesis, and metastasis. Apart from being an essential turnover process, autophagy is also a mechanism by which cells will be able to sustain temporary starvation and rid themselves of intracellular organisms that have invaded, although some pathogens have evolved mechanisms to prevent their destruction. Mutated lysosomal enzymes are the underlying cause of a number of lysosomal storage diseases involving the accumulation of materials that would be the substrate for the corresponding hydrolases, were they not defective. The normal, low-level diffusion of hydrogen peroxide into iron-rich lysosomes causes the slow formation of lipofuscin in long-lived postmitotic cells, where it occupies a substantial part of the lysosomal compartment at the end of the life span. This seems to result in the diversion of newly produced lysosomal enzymes away from autophagosomes, leading to the accumulation of malfunctioning mitochondria and proteins with consequent cellular dysfunction. If autophagy were a perfect turnover process, postmitotic ageing and several age-related neurodegenerative diseases would, perhaps, not take place